Friday, June 29, 2012

Awesome Twosome Drugs

So today I was asked two fixed dose combinations of drugs which antagonize each others side effects..
Lemme tell you about the combinations I thought of! :D

First.. *drum roll*
Aluminum hydroxide & Magnesium Trisilicate!
These two are antacids ie neutralize gastric acids

Magnesium salts act fast & Aluminum salts are slow acting
Magnesium salts act as laxatives & Aluminum salts are constipating
Magnesium salts hasten gastric emptying & Aluminum salts delay it

So.. What do you get when you mix em together? Dose reduction & minimization of systemic toxicity! ^_^

They are indicated in hyperacidity gastritis, reflux  esophagitis, dyspepsia

Second combination is seen in OCPs [Oral Contraceptive Pills]
Levonorgesterol & Ethinyl estradiol

Progesterone inhibits the frequency of LH secretory pulses & estrogen inhibits FSH secretion
So estrogen and progesterone synergise to inhibit ovulation
Estrogens increase the risk of endometrial carcinoma while progestin given concurrently blocks the risk..

So use em together!

Side effects of medicines combined (:

Each coin has two sides.. The trick is to use both sides to your benefit.. Team up!

Lemme know if know of any other such combinations.. Where the evils come together for the good without creating a dilemma..
Please do comment or email me and let me know.. :)

"I make bad look so good" -Megamind ;)
Have a nice day lol


Friday, June 22, 2012

Neuromuscular (myoneural) junction

Neuromuscular junction labelled

 Hello, lovely folks!

Lets learn something about the neuromuscular junction!
Refer the diagram as you read.. Otherwise it might not make sense to you..

1 As the nerve suppplying skeletal muscle reaches its termination it divides into a number of terminal buttons or end feet

2 The endfeet contains many small clear vesicles that contain acetyl choline, the transmitter at these junctions!

3 The endings fit into depressions in the motor plate - the thickened portion of the membrane at the junction

4 Underneath the nerve ending, the muscle membrane of the end plate is thrown into a number of folds called the junctional folds

5 The space between the nerves and the thickened membrane is comparable to a synapse! (Remember, this is a chemical synapse and there shall be delay.. In chemical synapses there is no delay)

 6 Ach muscle type nicotinic receptors are concentrated at the tops of the junctional folds of membrane of motor end plate

7 Only one nerve fibre ends on each end plate, with no convergence of multiple units

THIS, my dear friends, is known as the neuromuscular junction or myoneural junction

That's all! ^_^
You can use this as a ready made short note :P

Oh.. One more thing, in one of my first year vivas, I was asked what are the two types of Acetylcholine receptors..
The answer is nicotinic and muscarinic receptors.. There is an interesting story about how they were named!
Muscarinic receptors were named as such because they are more sensitive to muscarine.. isolated from a mushroom! :O
Nicotinic receptors could be opened by nicotine and hence the name!
Imagine someone naming you dust because you are sensitive to it! [That was a lame attempt to crack a joke on hypersensitivity reactions.. I should stop typing now :D ]


PS: I apologize for the awful diagram.. It's from one of my old notes, when I had no intentions of blogging :D
If time permits I'll update the diagram.. Till that you may rely on Google :)

If you do not heal yourself, you die

In some cases of myocardial infarction, the clot spontaneously resolves itself, this is the healing process.

But at the same time the atheroma can worsen, there maybe haemorrhage & disruption exposing the thrombogenic components causing expansion of the atheroma.

So do you get what I'm talking about? In life too we can either choose to heal or worsen our condition, it's your decision really.. To feel better or worse about the smallest thing or the biggest problem you think you have..

Do you choose to heal?