Wednesday, December 31, 2014

Why does hypophosphatemia cause an increased affinity for oxygen in the blood?

The mechanism for this is very fascinating.

Remember the reaction that generates 2,3-Bisphosphoglyceric acid (2,3-BPG)?

It requires phosphate!
No phosphate, no 2,3-BPG and therefore, increased affinity for oxygen!

2,3-BPG reaction
That's all!
Have a happy and phosphorous new year!

Related post: Oxygen - hemoglobin dissociation curve mnemonic


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