Wednesday, February 4, 2015

Study group discussion: Amantadine

Talking of antivirals... Amantadine is an antiviral used for Parkinson's disease! Anyone knowing it's mechanism in both these conditions?

Influenza is through M2 channel. Donno about Parkinsons.. Anticholinergic?

Amantadine increses the secretion of dopamine. Don't know the channels.

Mechanism of action of Amantadine: Prevents viral uncoating by binding to protein M2 (It's a protein which is a proton channel) that allows acidification of the viral core to activate viral RNA transcriptase.

Mnemonic: A man, to dine, takes off his coat!

Also, mutated M2 protein makes the virus resistant to the drug.

Woah! Thanks!

Amantadine MOA as a anti parkinsonian drug:
Increases release of DA
Increases synthesis of DA
Decreases reuptake of DA
Direct action NMDA receptors
*DA: Dopamine

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