Thursday, February 19, 2015

Study group discussion: Induction of enzymes by barbiturates

Why do barbiturates lead to hypertrophy of smooth ER and why do we need to increase the dose?

Barbiturates are CYP450 oxidase inducers. This enzyme is produced by smooth ER.. So there will be hypertrophy.

Ok agreed. But how the person becomes tolerant to the drug?

It is because the hypertrophied smooth ER metabolises the drug more causing adaptation.

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