Thursday, February 5, 2015

Study group discussion: von Willebrand factor and disease

Drug of choice for Von Willebrand factor deficiency?

I know this! Vasopressin!

Route? :D

I think.. Nasal spray?

Yes! The drug can't be used chronically but cause it just causes release of preformed vWF factors.

vWF is for platelet adhesion.. Right? In normal haemostasis?

Yes, vWF sticks platelets to the blood vessel wall. Gp 1b helps in platelet adhesion.

It's present in Weibel Palade bodies.

What are these bodies?

Weibel–Palade bodies store and release von Willebrand factor and P-selectin. Mnemonic:

And can any one name another disease related to Von Willebrand's factor? (Indirectly related)

Sullivan syndrome.

Umm woah I didn't know so many diseases with vWF.
I was thinking of thrombotic thrombocytopenic purpura.
ADAM TS 13 is defective, which is involved in the degradation of vWF

I didn't find any Sullivan syndrome!
I think he meant Bernard - Soulier syndrome.
Bernard Soulier, you mean?
Yeah. Still spelt it wrongly.
Haha it's okay! I was spelling "Wobble palade" bodies myself. I Googled before typing it though.

Study link!

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