Monday, June 13, 2016

Oral hypoglycemic drugs used for diabetes mellitus mnemonic

Hello!

So whenever there is a LOT of things to remember, like a lot of drug classes or a lot of microorganisms, I personify them. I make them real life characters and give them creep personality traits.

Here's a mnemonic kinda thingy on drugs used in diabetes mellitus aka oral hypoglycemics!
Biguanides: Inhibits hepatic glucogenesis and increases peripheral uptake of glucose.

Metformin meets glucose and advises it to stay out of the blood. It asks the liver to keep glucose in the house (Inhibits hepatic glucose production) and asks the glucose in the bloodstream to go into adipose and skeletal muscle (Stimulates peripheral uptake of glucose). Metformin never met a glucose molecule and did not tell him to not stay in blood :P

Metformin mnemonic
Sulfonylureas: Mimic action of glucose by closing K+ channels in pancreatic β cells, which leads to depolarization and increased Ca2+ influx,  releasing insulin.

Sulfonylureas summon insulin. They close the potassium gates in the haunted graveyard of the pancreas and chant depolarizing spells that open calcium channel. This brings back insulin from the dead. GlyBuride is more like Ghost Bringer.

Sulfonylureas mnemonic

Drugs ending with -gliptins (Sitagliptin, etc) are dipeptidyl peptidase 4 (DPP-4) inhibitors. They act to inhibit degradation of the endogenous incretins GLP-1 and GIP.
Mnemonic: GLIP!

DPP4 inhibitors mnemonic

Glucagon-like peptide-1 (GLP-1) receptor agonists stimulate GLP-1 receptors, thereby increasing insulin secretion.
Mnemonic:  A tide of insulin is secreted after GLP1RA reaches the receptor shores.
Exenatide liraglutide, etc.
Association with weight loss - Mnemonic:  Tides is an anagram for diet - so tides cause increased satiety and reduce diet :D

GLP-1 receptor agonists (GLP-1 RAs) mimic the effects of incretins (which augment glucose-stimulated pancreatic insulin secretion). Dipeptidyl peptidase 4 (DPP-4) is an enzyme that degrades incretin, so DPP-4 inhibitors will result in increased incretin (and therefore insulin) levels. The mechanism of action of DPP-4 inhibitors is similar to GLP-1 receptor agonists, so these classes of drugs are not used in combination with each other. 
Mnemonic: Tin with Tide is not a good idea! (SitaglipTIN with SemagluTIDE is not a good idea!)

α-glucosidase inhibitors:
Acarbose - Alpha glucosidase inhibitor. Aaaaa!

Amylin mimetics:
Amylin rhymes with insulin to remember that amylin mimetics like pramlintide increase secretion of insulin and delay gastric emptying.

Glitazones (thiazolidinediones) mnemonic:
Pioglitazone - PI
Peroxisome proliferator-activated receptors (PPARs)
Improves insulin sensitivity

Also, remember that thiazolidinedione derivatives
THiazoLidinedione: Toxic to Heart and Liver

Sodium-glucose co-transporter 2 (SGLT2) inhibitors: Canagliflozin, Empagliflozin, Dapagliflozin, Ertugliflozin
Mechanism: Blocks renal glucose absorption, resulting in glycosuria.
Mnemonic: GliFlozIN makes Glucose Flow In Nephrons

That's all!

18 comments:

  1. Hey ikan,
    thanx for that 😊😊😊

    ReplyDelete
    Replies
    1. Very nice. Both telling simple stories, with accompanying pictures creates anchors and connections which makes recall more spontaneous.

      Delete
  2. Have you stopped adding people to study groups?

    ReplyDelete
    Replies
    1. No, we are still adding people.

      Can you write us another email... Maybe we didn't recieve your email :/

      Delete
  3. Thank you! This is so cute! ^_^

    ReplyDelete
  4. Thanks Ikan. Your mnemonics are awesome.

    ReplyDelete
  5. After remembering all the names of drugs...Do they actually come to our mind in exams?

    ReplyDelete

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