Wednesday, November 23, 2016

Membranous glomerulonephritis notes

This post is on membranous glomerulonephritis :D

- Most common cause of nephrotic syndrome in adults (Peak incidence between 30-50 years).
- Glomerulonephritis with highest incidence of thrombosis.

Associated with :
- Malignancy (Solid tumors of breast, colon, lung)
- Infections (Hepatitis B, malaria, schistosomiasis)
- Rheumatological disorders like lupus, RA
- Drugs like captopril, penicillamine, NSAIDS

What does membranous glomerulonephritis look like?
- Light microscopy: Uniform thickening of the basement membrane is seen.
- Jones silver stain: Spike and dome because protein is highlighted in black and deposits lie between the spikes which are not deposited.
- Immunofluorescence: Granular deposits of IgG and C3.
- Electron microscopy: Electron dense subepithelial deposits.

That's all!
Get to know your parents, you'll never know when they're gone :)


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