Istradefylline (Selective Adenosine 2A receptor antagonist), inhibits the adenosine's inhibitory effect on GABAergic transmission in direct nigro-striatal pathway while simultaneously inhibiting adenosine's stimulatory effect on GABAergic transmission in indirect nigro-striato-pallidal pathway, ultimately leading to stimulation of thalamo-stimulatory direct pathway and inhibition of thalamo-inhibitory indirect pathway.
Also, it inhibits glutamate release by virtue of inhibition of presynaptic A2a receptors explaining it's neuroprotective effect, approved for Parkinson's.
Pretty intricate and neat, right?
-Kirtan Patolia
Also, it inhibits glutamate release by virtue of inhibition of presynaptic A2a receptors explaining it's neuroprotective effect, approved for Parkinson's.
Pretty intricate and neat, right?
-Kirtan Patolia
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