Selinexor (Selective inhibitor of nuclear export) inhibits XPO1 (exporter protein 1).
XPO1 is often overexpressed in tumors leading to transport of tumor suppressor proteins like p16, p14, p27 from nucleus to cytoplasm and there by evading the apoptosis.
At the same time XPO1, along with eIF4E also enhances transport of oncogene mRNA like c-myc, cyclin D1 and mdm2 from nucleus to cytoplasm and enhances their translation.
Thus by inhibiting XPO1, it selectively leads to the apoptosis of tumor cells by retaining tumor suppressors in nucleus, and decreases proliferation potential by retaining oncogenes mRNA in nucleus there by preventing their translation, approved for multiple myeloma.
Pretty dazzling!!! Simply stunning, right?
-Kirtan Patolia
XPO1 is often overexpressed in tumors leading to transport of tumor suppressor proteins like p16, p14, p27 from nucleus to cytoplasm and there by evading the apoptosis.
At the same time XPO1, along with eIF4E also enhances transport of oncogene mRNA like c-myc, cyclin D1 and mdm2 from nucleus to cytoplasm and enhances their translation.
Thus by inhibiting XPO1, it selectively leads to the apoptosis of tumor cells by retaining tumor suppressors in nucleus, and decreases proliferation potential by retaining oncogenes mRNA in nucleus there by preventing their translation, approved for multiple myeloma.
Pretty dazzling!!! Simply stunning, right?
-Kirtan Patolia
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