Friday, December 27, 2019

Fact of the day: AHN in old age


Fact: New neurons proliferate as we age, in both physiologically and pathologically aging brains, even in the ninth decade of life.

Adult hippocampal neurogenesis (AHN) is a process that actively plays its role in neurologically healthy brains, but becomes deficient in those with Alzheimer's disease.

Under tightly controlled conditions and using some particular tissue processing methods, samples are obtained and identification of new neurons in dentate gyrus, called doublecortin -expressing (DCX) neurons (in thousands) in varying degrees of maturation is done; confirmation by using anti - DCX antibodies which are raised against this protein.

Also, expression of prospero homebox ( Prox 1) suggests DCX as a reliable marker of immature dentate granule cells (DGCs) in the hippocampus even of old- aged.

That's all
- Jaskunwar Singh

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