A compilation of similarities between corneal dystrophies

Many dystrophies have commonalities. Following are enumerated as under-

1. Associated with TGF Beta1 mutations-

       - Epithelial basement membrane dystrophy

       - Reis- Bückler's 

       - Thiel- Behnke 

       - Lattice and granular(type1) dystrophies

2. Associated with mutations on 5q31 locus-

         - Reis- Bückler's

         - Lattice and granular(types 1 and  2)

3. Autosomal recessive -

          - Gelatinous drop like

          -.macular

          - Congenital hereditary endothelial( type 2)

4. X linked- 

           - Lisch ( X linked dominant) 

-All others are autosomal dominant. 

5. Chromosome 12- Meesman's, congenital 

                                     hereditary stromal.

6. Chromosome 20- Posterior polymorphous, 

                                    congenital hereditary 

                                     endothelial.

7. Chromosome 1- Gelatinous drop like,

                                   posterior polymorphous.

8. Amyloid deposition is seen in- 

                   - Gelatinous drop like

                   - Lattice

                   - Granular (type2) 

                   - Congenital hereditary endothelial.

9. Bowman's membrane is lost in- 

                   -Gelatinous drop like

                   - Reis-Bückler's (replaced by irregular

                       material

                   - Thiel-Behnke's ( replaced by a

                       fibrocellular layer)

10. Recurrence after keratoplasty-

                    -  Reis-Bückler's

                    -. Lattice, granular, and macular

                    - Schynder 

                     -  Congenital hereditary stromal.

11. Association with glaucoma and keratoconus-

                    - Posterior polymorphous

                    - Fuch's endothelial. 

Now don't blame me for the list being too exhaustive 🙄

Source- Postgraduate ophthalmology by Zia Chaudhari and M Vanathi 

-Sushrut