Hi! So let's learn EDS together. I've tabled a list of high-yield points of all the types of EDS. It requires little bit of revision but once you get a pictorial familiarity you should be able to recall them all.
Have fun!
So, how to remember?
Step 1. Divide the table into 2 halves. Sl no. 1,2,3 have in common a lot of features:
- They are all Autosomal Dominant.
- They have common Clinical features - skin HYPERelasticity, joint HYPERmobility and HYPER (easy) bruising.
- Go serially, Classical has the first 2, Type I and II and HYPERmobile is III and lastly Vascular is type IV
- Vascular type has additionally - arterial & uterine rupture.
Step 2. Now the second section Sl no. 4,5,6
- EDS types with enzyme defects are Autosomal Recessive. So, 4 and 6 are AR.
- Kyphoscoliotic EDS is Type VI (K rearranged is a V and I)
- For the last 2, mnemonic is ABCDð Arthrochalasia VII a, b and VII c is Dermatosparaxis.
- KyphoSCOLIOTIC EDS - defective lysyl hydroxylase (=> abnormal cross linking of collagen or KOLLAGEN => think of bones ðĶī => congenital SCOLIOSIS)
- ARTHROchalasia is COL IA (1st letter is A) and hence presents with severe JOINT hyper mobility.
- DERMATospARaxis is AR and a defective Procollagen-N-peptidase and presents with CUTIS laxa. (Cuties are Pros ;)
Step 2. For the Gene types, come down in descending order: 5 4 3 2 1 0
Step 3. Remember Type V - DOEST NOT EXIST.
Step 4. Revise again ð
That's it! Stay safe ðļ
- Anagha :)
Very helpful!
ReplyDeleteVery good
ReplyDeleteIt was really helpful, Thanks! :)
ReplyDelete- a fellow medico