Sunday, January 2, 2022

DRESS syndrome and Dressler's syndrome - what's in a name?


DRESS syndrome and Dressler's syndrome - what's in the name?

DRESS syndrome - an acronym

Drug Rash with Eosinophilia and Systemic Symptoms 

- delayed type IV-b hypersensitivity reaction (immune-mediated)

- occurs up to 2-6 weeks after starting the offending agent/drug(s)

- fever >38 C, morbilliform rash, lymphadenopathy (at least two sites), multi-organ involvement

- eosinophils >700 uL, atypical lymphocytes

- raised ALT

- offending drugs: penicillins, vancomycin, carbamazepine, phenytoin, rifampin, isoniazid, nitrofurantoin, sulfa drugs, omeprazole, captopril, allopurinol (Differential diagnosis: Stevens- Johnson syndrome )

- more prevalence in patients with renal and liver dysfunction and with use of diuretics (source)

- may be associated with reactivation of HHV-6


Dressler's syndrome - named after a cardiologist William Dressler, 1956

- post-cardiac injury syndrome

- auto-immune mediated pericarditis

- up to 2-8 weeks after severe/transmural MI

- patient may have a h/o viral/fibrinous pericarditis or other antiviral infections.

- a young patient with B-negative blood group (source)

- may be a h/o use of halothane anesthesia

- triad of pleuritic chest pain, pericarditis, and pneumonitis with low-grade fever.

That's all

- Jaskunwar Singh

No comments:

Post a Comment

This is express yourself space. Where you type create something beautiful! <3
Wondering what do I write? Well...
Tell us something you know better. You are a brilliant mind. Yes, you are! ^__^
Ask about something you don't understand @_@?
Compliment... Say something nice! =D
Be a good critic and correct us if something went wrong :|
Go ahead. Comment all you like here! (:

PS: We have moderated comments to reduce spam. ALL comments that are not spam will be published on the website.