Sunday, May 24, 2015

Study group discussion: CPS 1 and CPS 2

Today's discussion is about Carbamoyl Phosphate Synthetase!

What are differences between CPS 1 and CPS 2?

CPS 1 works in the urea cycle.
CPS 2 in pyramidine synthesis.

CPS 1 is mitochondrial.
CPS 2 is cytosolic.

(Medicowesome mnemonic: Two is cys-two-lic)

The source of nitrogen for CPS 1 is ammonia.
For CPS 2, it is the amide group of glutamine.

N acetyl glutamate is activator for CPS 1.
ATP is activator for CPS 2.

Woah that's a lot of points I didn't know about!


  1. Forget to tell that time... UTP is inhibitor of CPS 2

  2. Nice just got a quick revision of the difference.


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