Sunday, May 24, 2015

Study group discussion: CPS 1 and CPS 2

Today's discussion is about Carbamoyl Phosphate Synthetase!

What are differences between CPS 1 and CPS 2?

CPS 1 works in the urea cycle.
CPS 2 in pyramidine synthesis.

CPS 1 is mitochondrial.
CPS 2 is cytosolic.

(Medicowesome mnemonic: Two is cys-two-lic)

The source of nitrogen for CPS 1 is ammonia.
For CPS 2, it is the amide group of glutamine.

N acetyl glutamate is activator for CPS 1.
ATP is activator for CPS 2.

Woah that's a lot of points I didn't know about!

5 comments:

  1. Forget to tell that time... UTP is inhibitor of CPS 2

    ReplyDelete
  2. Nice just got a quick revision of the difference.

    ReplyDelete
  3. Cytosolic and mitochondrial carbamoyl phosphate synthetase
    have the following similarity:
    (A) Both use ammonia as a substance (B) Both provide carbamoyl
    phosphate for urea
    synthesis (C) Both require N-acetylglutamate as an
    activator (D) Both are allosteric enzymes.
    What should be the ans of this question

    ReplyDelete
  4. Cytosolic and mitochondrial carbamoyl phosphate synthetase
    have the following similarity:
    (A) Both use ammonia as a substance (B) Both provide carbamoyl
    phosphate for urea
    synthesis (C) Both require N-acetylglutamate as an
    activator (D) Both are allosteric enzymes
    .
    What should be the ans to this question

    ReplyDelete

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