Hello!
Bartters, Gitelmans and Liddles syndrome present with chloride resistant (high urinary chloride) hypokalemic metabolic alkalosis.
What differentiates them:
Bartters: Hypercalciuric (Furosemide like! Loops lose calcium, remember?)
Gitelman: Hypocalciuric (Thiazides don't!) and Hypomagnesemia. Presents with cramping and spasms.
Liddles: Presents with hypertension, metabolic alkalosis and hypokalemia (Aldosterone excess like, but it is truly pseudohyperaldosteronism!)
Bartters, Gitelmans and Liddles syndrome present with chloride resistant (high urinary chloride) hypokalemic metabolic alkalosis.
What differentiates them:
Bartters: Hypercalciuric (Furosemide like! Loops lose calcium, remember?)
Gitelman: Hypocalciuric (Thiazides don't!) and Hypomagnesemia. Presents with cramping and spasms.
Liddles: Presents with hypertension, metabolic alkalosis and hypokalemia (Aldosterone excess like, but it is truly pseudohyperaldosteronism!)
It is characterized by: Hyporeninemic hypoaldosteronism, hypertension, hypokalemia and enhanced erythrocyte sodium influx
Here's a mnemonic for it!
"FaceBook GoT ALL pseudo HYPER about a Little syndrome"
FB - Bartter's is like Furosemide
GoT - Gitelman Thiazide
All pseudo hyper little - Liddles is like pseudo HyperALdosteronemia (Remember, it is pseudo - aldosterone levels are normal/low)
That's all!
Here's an aphorism by Sir William Osler: “Care more for the individual patient than for the special features of his disease.” :)
-IkaN
HELLO! CAN ANYONE POST THEIR CONCEPTS AND MNEMONICS ON IMMUNOLOGY PLEASE
ReplyDeleteHi, may I ask for Liddle syndrome is the distal convoluted tubules or collecting duct that is affected?
ReplyDeleteAccording to Robbins it’s Distal tubule👍🏻
Deleteits collecting duct
DeleteCollecting ducts
Deletethankyou
ReplyDeleteLiddles- low aldosterone low renin
ReplyDeleteNot hyper aldosteronism
Yes
DeleteHypertension with hypokalemia and metabolic alkalosis
Delete