Analgesic nephropathy
Characterized by:
Renal insufficiency
Papillary necrosis
Due to:
Toxic drug levels in inner medulla
Causes chronic tubulointerstitial damage
Results from papillary ischemia due to vasoconstriction of medullary blood vessels (vasa recta)
Caused by:
Phenacetin containing preparations
Aspirin
Caffeine
Symptoms:
Polyuria (Due to impaired concentrating ability)
NAGMA (Due to tubular damage)
Hematuria (Due to sloughed necrotic papilla)
Sterile pyuria and WBC casts may also be seen
Ureteric colic, obstruction (Due to sloughed necrotic papilla)
At increased risk of:
Premature aging
Atherosclerotic vascular disease
Urinary tract cancer
That's all!
-IkaN
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