Monday, December 26, 2016

Restless leg syndrome notes

RLS symptoms:
Urge to move legs
Symptoms begin with rest
Relief on movement

Associated with:
Anemia
Pregnancy
Renal failure
Peripheral neuropathy

Pathogenesis:
Disordered dopamine function in association with abnormal iron metabolism

Treatment:
Sleep hygiene
Pramipexole, ropinirole
Iron for IDA

That's all!
-IkaN

Membranous and pseudo-membranous conjunctivitis notes

Pseudo-membranous conjunctivitis: mild form
Membranous conjunctivitis: severe form

Causative agents:
Corynebacterium diphtheriae
Beta- hemolytic streptococci
Streptococcus pneumoniae
Neisseria gonorrheae

Associated conditions:
Erythema multiforme
Stevens- Johnson syndrome

Pseudomembranous:
- Lid swelling
- mucopurulent bloody discharge
- white membrane
- easily peel off without bleeding

Membranous:
- Lids are hardened
- semisolid exudates: result in necrosis of conjunctiva and cornea
- difficult to peel off
- associated with bleeding from the undersurface

Important points to be noted:-
- The membrane forms more commonly over palpebral conjunctiva beginning from the edge of lid.
- There is enlarged preauricular lymph nodes with suppurative discharge.
- Marginal corneal ulcer due to secondary infection (especially streptococci).
- high risk of symblephron (adhesion between palpebral and bulbar conjunctiva)

Treatment:
- Penicillin (10,000 units/ ml) is the doc for acute diphtherial infection. Systemic administration and a quick injection of anti- diphtheritic serum (4,000- 10,000 units BD) 
- Removal of the membranes is not advised because of the risk of adhesion (symblephron).
- Local and systemic administration of bacitracin and penicillin is recommended in case of streptococcal infection.

Pseudotumor cerebri notes

Pseudotumor cerebri

Associated with:
Obesity
Vitamin A toxicity

Signs and symptoms:
Headache
Sixth nerve palsy
Visual field defects
Pulsutile tinnitus

Diagnosis:
Papilledema
To rule out space occupying lesions - CT / MRI normal
Most accurate - Lumbar puncture with opening CSF pressure measurement

Treatment:
Weight loss
Acetazolamide
Surgery

Why does increased ICP cause 6th nerve (Abducens) palsy?
Increased ICP can result in downward displacement of the brainstem, causing stretching of the sixth nerve secondary to its location within  Dorello's canal.

That's all!
-IkaN

Sunday, December 25, 2016

Amaurosis fugax mnemonics

I was studying the causes of Amaurosis fugax today.. so i just made random mnemonics and thought of sharing with you guys :D

Amaurosis fugax is a transient uniocular loss of vision either due to lack of blood supply to the brain or to the retina itself.

Disease modifying therapies for relapsing forms of multiple sclerosis - MS treatment mnemonic

Hey!

I was reading treatment for MS today.

Do you want to remember the disease modifying therapies for relapsing forms of multiple sclerosis?

Here's a mnemonic! "Ms is Nat (not) glad. All terrified by mighty ox with fuming fungus."

Multiple sclerosis (Ms)
Natalizumab (Nat)
Glatiramer acetate (Glad)
Alemtuzumab (All terrified)
INF beta (By)
Mitoxanthrane (Mighty ox)
Dimethyl fumarate (Fuming)
Fingolimod (Fungus)

Remember, for acute attacks, use Glucocorticoids.

That's all!

-IkaN

Neurofibromatosis type 1 - Another mnemonic

Hey!

So I needed another mnemonic for neurofibromatosis because my first mnemonic wasn't good enough xD

This time, the mnemonic is NODES!

That's all! 

Merry Christmas everyone! 


-IkaN

Neurofibromatosis type 1 old mnemonic: http://www.medicowesome.com/2014/10/neurofibromatosis-1-mnemonic.html

Syndromic Management Of RTI/SRI

*Syndromic Management*📁📗🏳📘📕📒📓

Mnemonic :: *Great Girls Wont Buy Red Yellow Bags*

*Kit 1 - Grey*
*Kit 2 - Green*
*Kit 3 - White*
*Kit 4 - Blue*
*Kit 5 - Red*
*Kit 6 - Yellow*
*Kit 7 - Black*

*Kit 1 is GreaT*
Gonorrhea
C.Trachomatis

*Kit 2 is Green*
_*BV CA Green TV*_
Coz no self respectingan would buy a green TV...he'll buy it out of love for wife😜😜😜

Bacterial Vaginosis
Candida Albicans
Trichomonas Vaginalis

*Kit-3 is ABC*
Azithral
Benzathine penicillin

For Chancre and chancroid

Also notice C is 3rd letter and 3 letters ABC in the mnemonic for Kit 3

*Kit - 4 Remember that if you forget this then its BAD*

Blue
Azithral coz allergy to penicillin
Doxy

*Kit - 5 is Red as in Mnemonic*
Remember that Red is for love and love is *Her* eyes and smile
*Her*petic

*Kit - 6 is Yellow as in Mnemonic*

Yel *low* for *low*er abd pain
PID

*Kit - 7 is Black* coz last colour is the colour palate also BLAC

Bubo
LGV
Azithral
Chancroid

Saturday, December 24, 2016

Vitamin D and multiple sclerosis

Hey awesomites!

Since I have written posts regarding the association of vitamin D deficiency with certain neurological disorders previously, I am here again with one more addition into the box (on sincere request of our main author IkaN.. :p ).

Anticholinesterase

Hey here is exclusive classification of anticholinesterase drugs !,hopefully it will be useful.

~Ojas

Thursday, December 22, 2016

Hypoglycemia mnemonic

Hypoglycemia may present as a mere symptom of a disease or a life- threatening condition itself. I have made a mnemonic on the common signs and symptoms in a patient of hypoglycemia. Here it is..
METABOLISM

M- Mood swings
E- Excess sweating
T- Tachycardia
A- Adrenal fatigue
B- Blood pressure changes
O- Obesity
L- Lips tingling
I- Increased appetite/ hunger
S- Shakiness (tremors)
M- Muscle pain


That's all
- Jaskunwar Singh

Crispy C.R.I.S.P.R.!

10 years ago,only a few would have thought that a device in our pockets would be good enough to access all the information of the world, would do social networking, calls, would calculate, act as a torch and what not. 

We today are on a similar brink ofrevolution in genetic engineering, where the effects would be so magnificent that they would need to be measured on a Richter scale! 

Enter CRISPR, which is an acronym for 'clustered regularly interspaced shortpalindromic repeats', a  crispy new technology which promises to shrink the costs involved in genetic engineering by 90%makes the procedure easier andshorter.

*What is it? 
We have managed to hack an antibacteriophage mechanism in bacteria to our advantage. 

Only a few bacteria survive bacteriophage invasion. To protect themselves from a further invasion, they store a part of the phage DNA into their archives. 

When another attack does occur, an RNA copy of the archived phage DNA is presented to what is known as a CAS 9 protein.

CAS 9 compares the two copies, one from the foreign DNA and the other from the archives, and is very precise at that. 

If it finds a 100% match, it cuts off thenew phage's DNA, thus rendering the attack a big embarrassment for the bacteriophage. :-p 

*What can we do with it? 
Oh, a lot of awesome things! 

-Pissing off viruses
In 2015, scientists armed with CRISPR achieved a significant reduction of HIV load from patiens. 
This year, in mice, they slashed off 51% HIV DNA from mice, just by a couple of shots in their tails! 

*Making cancer re evaluate its careerchoice
Malignant cell detection by the immune system can be enhanced. 

*Designer babies- 
A lot of desirable traits- super awesome eyesight, superman esque strength and so on, can be selected from a wide palette during embryogenesis.

*Bidding adieu to genetic diseases

*Making ourselves look hot at 120-

CRISPR holds the potential to slow and even reverse ageing! We can take a leaf off the books of certain aquatic species who already are doing that. 

.. and a lot more. 

*The last word
A few controversies sorround though.
- We don't know if any adverse 
  reactions may triggered, as our 
  knowledge is still just the tip of the
  iceberg.
- Some powers like say dictators
   might use it to gain precedence.
- The fear of genetic pollution.

Anyway, these are just hurdles which we need to plan and overcome for a glorious future for humanity! 

Source- Kurzgesagt. 


  


Wednesday, December 21, 2016

Symptoms of corneal disorders mnemonic

I was studying corneal disorders and dystrophies, infections, inflammations today and noticed many common symptoms in the patients.
Now since its the matter of the eye, I must tell you how much I love photography and also i used to do some painting stuff long ago. So i made a random mnemonic out of it for the symptoms of corneal disorders.. :p
DSLR Photography and Painting Workshops.

D- Decreased vision
S- Sensations (foreign body)
L- Lacrimation
R- Redness
P- Photophobia
P- Pain
W- white cornea


Thats all
- Jaskunwar Singh

Bullous skin disorders-1 pemphigus vulgaris and bullous pemphigoid

Pemphigus vulgaris



http://www.medpictures.org/pemphigus-vulgaris-pictures.html

Bullous pemphigoid


http://www.pcds.org.uk/clinical-guidance/bullous-pemphigoid1#!prettyPhoto



these two are the most commonly asked questions within bullous diseases.
the major difference you need to know is
pemphigus vulgaris- bullae are suprabasal. hence these are not tense and rupture easily..not very common in a clinical case for you to find a bulla
bullous pemphigoid- bullae are subepidermal..and hence tense.

a mnemonic..like a bull..bullae in Bullous pemphigoid are tough and stronger

-sakkan