Hello everyone !
Mnemonic :
Fun fact: Fragmented QRS can be caused by conduction around the scarred myocardium, resulting in multiple spikes within the QRS complex.
-IkaN
What is the no-reflow or low reflow phenomenon?
If blood flow to the ischemic tissue continues to be impeded after relief of the occlusion.
Why does this happen?
After prolonged cessation of coronary perfusion and restoration of blood flow to the epicardial coronary arteries, structural damage occurs to the microvasculature that prevents the restoration of normal blood flow to the cardiac myocytes. Various mechanisms are implicated in the genesis of the no-reflow phenomenon.
Hello Awesomites!
Enjoy this crisp post on SLC gene mutations.
SLC= Solute carrier
SLC39A4 | Acrodermatitis enteropathica |
SLC26A4 | Pendred |
SLC6A9 | Hartnup disease |
SLC5A2 | Renal glucosuria |
FYI-Diseases associated with SLC6A4 include Anxiety and Obsessive-Compulsive Disorder
For further information read this article SLC transporters as therapeutic targets.
Hi
Reversible inhibitors of ADP-r (P2Y12) such as ticagrelor, cangrelor, and elinogrel used as anti-platelet drugs have a unique side effect of dyspnea, unlike the irreversible ones. This is hypothesized to occur because of reversible inhibition of ADP-r on sensory neurons. Since half-life of the reversible inhibitors is shorter than that of irreversibles, repeated doses lead to permanent inhibition of the P2Y12 receptors on sensory neurons.
Moreover, oral administration is found to cause more severe effects on the breathing difficulties than the parenteral route.
Source- Research gate
That's all
- Jaskunwar Singh