A posterior staphyloma is common because the durability of the layers of the eye where the optic nerve enters the eye is lesser in comparison.
-That's all!
Sushrut Dongargaonkar
Thursday, June 15, 2017
Pills of knowledge in Ophthalm- Posterior staphyloma
Pills of knowledge in Ophthalm- Moxifloxacin
Moxifloxacin is the preferred antibiotic in Ophthalmic surgeries and pathologies because it gets concentrated into the anterior chamber and the aqueous.
That's all!
-Sushrut Dongargaonkar
EMG and NCS - Review
Hello there!
Today we'll see some important points on Electromyography (EMG) and Nerve conduction studies (NCS).
EMG evaluates abnormal electrical activity in muscles, and NCS investigates how electricity flows through a nerve.
They help to locate and determine the causes of diseases that affect muscles and peripheral nerves.
Procedure:
In EMG, a small needle is inserted into a muscle, to measure its electrical activity. In NCS, electrodes are placed on the skin overlying a nerve, and other recording electrodes are attached at a different point over the same nerve and a small shock is applied, and the electrical impulse is recorded.
Understanding the terminologies and results of these tests-
Amplitude: The electrical signal is represented as a wave, and the amplitude is its height.
ConductionVelocity (CV): The conduction velocity describes the speed at which the electrical impulse travels along the nerve.D
Duration This describes the width of an electrical wave.
ConductionBlock: The diminution of signal across an anatomical region such as the wrist. This suggests nerve entrapment.
So when a nerve stimulates a muscle to contract, there is a brief burst of electrical activity called a motor unit action potential (MUP).
Some of the abnormal responses seen are:
1)Fibrillations & positive sharp waves on the monitor seen in diseases of peripheral nerves.
Muscles sometimes start having spontaneous activity on their own.
2)Fasciculations: Sometimes the abnormality causes visible muscle twitches.
3)Abnormally large MUPS : These are seen If a nerve has been injured and then regrows.
On regeneration the nerve tends to branch out to include a wider area of the muscle and hence we get large motor unit potentials on the screen.
4) Abnormally small MUPS: When they're abnormally small or brief it suggests the presence of a disease of a muscle (a myopathy) where the muscle is unable to contract to and fails to provide the normal amplitude of the wave.
5)"Recruitment pattern": As a muscle is contracted, nerve fibers signal more and more bits of muscle (called motor units) to join in and help.
In a neuropathic disorder, the amplitude of different motor units is strong, but there are fewer of them because the nerve is unable to connect to as many units.
In myopathies, the number of motor units is normal, but the amplitude is smaller
You may never come across an actual EMG for an interpretation,but it is always good to know the investigation.
The interpretation of EMG and NCSs is not always straightforward and may not always lead to just one possible diagnosis — but the tests can reduce the number of diagnostic possibilities.
Hope this was helpful!
Let's Learn Together!
-Medha.
New TB Risk Factor
People with low levels of vitamin A who live with individuals who were sick with tuberculosis were 10 times more likely to develop the disease than people with high levels of the nutrient, according to research led by investigators at Harvard Medical School.
Vit A rich foods: Liver, fish, hard-boiled egg(not omelette), cheese, butter, cheddar etc
And now some vegetables: Sweet potato, Carrot, Squash, Spinach, Lettuce
Some fruits: Mango, Papaya, Guava, Watermelon, Apricot, Passion fruit
Another reason to love Mango!
-VM
Research update: Statins may increase risk of Parkinsons' disease
A new research by neuroscientists has updated our knowledge about the association between high cholesterol levels in people and prevalence of neurodegenerative diseases such as the Parkinson's.
Mind - wandering : How your body reacts to it?
First lets have a word about mind - wandering.. "Mind- wandering (or task-unrelated thoughts) is an experience of thoughts which are totally unrelated to the task you are doing right now, especially when it demands attention. It involves activities such as reading, driving, attending lectures, etc."
Wednesday, June 14, 2017
Dibucaine Number.
Hello !
Let's see what this Dibucaine number is.
So Dibucaine is a local anesthetic.
Dibucaine inhibits 80% of the normal Pseudocholinesterase enzyme and 20% of the Atypical enzyme.
The number is determined by measuring the percentage of Pseudocholinesterase enzyme that remains unchanged in the blood of individuals administered a standard dose of Dibucaine intravenously.
Normal Dibucaine number is 70-80% i.e 70-80%of normal enzyme is inhibited by Dibucaine.
If there is a point mutation in the enzyme making it a Atypical Pseudocholinesterase then Dibucaine will not be able to inhibit it and the number will decrease.
This number is used to measure the activity of Atypical Pseudocholinesterase,and to assess the likely hood of prolonged apnea after succinylcholine administration.
Sodium Fluoride can also be used in place of Dibucaine.
If you know more on it Add to this information.
Let's learn Together!
-Medha.
Monday, June 12, 2017
Contraindications for Noninvasive Ventilation Mnemonic
Hey guys
This is one of my rare mnemonic posts. I don't post much on this coz most of my mnemonics are kinda personal if not socially inappropriate :p
So Noninvasive ventilation, imagine having a mask on ur face, all air tight, almost strangulating and as if this isn't enough, with multiple tiny outlets giving jets of air which are titillating your highly itchable nasal area.
Unpleasant, right?
Talking of unpleasant, you do remember Hitler, right?
He GAAASED the Jews, since that's not a possibility for us since we all love Zuckerberg let's think about something on a similar note.
"GAAAS the HOEs"
G- GI bleeding
A- Aspiration
A- Angina( including MI)
A- Arrest( Cardiac and Respiratory)
S- Surgery on ur face
H- Haemodynamic instability
O- Obstruction ( in upper airway)
E- Encephalopathy ( Severe)
S- _____
I've left the last one blank for the reader to fill up. Hint: It has something to do with obstruction of the lower airways.
Hope this is helpful!
-VM
Sunday, June 11, 2017
Study Group Discussion: Salisbury Phenomenon
Whats Salisbury effect?
It's a very interesting phenomenon.
It states that when coronary collaterals develop in the face of myocardial ischemia, they improve the blood supply. However they physically restrict left ventricular dilation and thereby raise LVEDP(LV end diastolic pressure) and reduce LV compliance.
This is because they act like tendrils/scaffold which prevent ventricular dilation.
Nice one!
-VM
Ductus Arteriosus : Review of Key Points
Hi everyone ! Just a short review on Ductus Arteriosus.
- Ductus Arteriosus is basically a communication between the Pulmonary trunk and the Systemic Aorta.
- This communication is between pulmonary trunk and the end of Arch of aorta. Just after the Brachiocephalic trunk , and Left Common carotid and Subclavian have branched off.
- In embryonic life this communication helps transport blood from RV- Pulmonary artery to the Systemic circulation.
So ,
Remember :
Prostaglandins Persist
-Prostaglandins, especially PGE1 , act on the Ductal muscle tissue and keep it Open.
-So the Ductus arteriosus stays open.
-This is important in certain Duct dependent lesions
- Duct dependent heart lesions are those which need the presence of an Open ductus to receive blood in systemic / Pulmonary circulation.
- For example -->
✓ Duct dependent lesions for Systemic Circulation are those that cause obstruction to the Left side heart to pump blood into the aorta. These include :
- Coarctation of Aorta ( especially pre Ductal ) : Here there is a constriction of the aorta just before the ductus Arteriosus. So , a persistent Ductus would transport blood from pulmonary circulation into the systemic.
If ductus gets closed , there would be minimal blood flow to the Lower limbs and abdomen.
- Critical Aortic stenosis.
- Left side Hypoplastic heart.
~~~~~~~~~~~~~~~~~~~~~~~~~
✓ Duct dependent lesions for pulmonary circulation
-These are lesions where pulmonary blood flow would be severely reduced due to some RV- Outflow tract Abnormality and the only source to the lungs would be through the ductus shunting some blood from aorta into the pulmonary vein.
- These include :
- Critical Pulmonary Stenosis
- Hypoplastic Right heart syndrome
- Tetrology of Fallot
- Tricuspid Atresia
- Ebstein Anomaly
Another important disease is Transposition of the great vessels where this sort of corrects the defect.
~~~~~~~~~~~~~~~~~~~~~~~~~
So. We've seen in what conditions we'd like to keep the Ductus Arteriosus open / persistent.
Normally this Ductus closes functionally within 24 hours of birth. And anatomically between 10 and 14 days post natally.
If this persists on its own for a long time it causes a Congenital Heart Disease called Patent Ductus Arteriosus.
This defect is characterised by shunting of blood into the pulmonary trunk constantly during systole and diastole causing a Continuous murmur.
To close this ductus , we could try using Indomethacin / Ibuprofen especially in preterm children.
These drugs inhibit Prostaglandin synthesis , thus causing Ductus Smooth muscle to constrict and eventually close.
So that's all about the ductus !
Happy studying !
And Stay Awesome !
~ A.P.Burkholderia
Saturday, June 10, 2017
Jaundice Syndromes : Mnemonic
Hey everyone. Just a short post on how to remember the Jaundice Syndromes.
So.
Remember :
CGI
(As in the CGI special effects in movies.)
C - Criggler Najjar Syndrome
G - Gilbert Syndrome
I - Indirect Jaundice ( Unconjugated Bilirubin).
So this would make Dublin Johnson and Rotor Syndromes Direct Jaundice.
Another useful fact :
All are inherited as Autosomal recessive trait except Gilbert and Criggler Najjar 1.
Hope this helped !
Happy studying.
~ A.P.Burkholderia
Lowe syndrome mnemonic
Lowe Syndrome (Oculocerebrorenal dystrophy) mnemonic
Think of Lowe = Love and it'll make sense.
Lowe makes you blind (cataracts, glaucoma)
Lowe makes you HAPpy (High Alkaline Phosphatase along with normal calcium, low phosphate)
Lowe messes with your head (intellectual disability)
LoveR - Renal defects (proximal tubular acidosis, aminoaciduria, and low-molecular-weight proteinuria)
Lowes syndrome is a cause of Fanconi syndrome.
That's all!
-IkaN
Renal Cell Carcinoma Etiology : Summary
Hi everyone. Here's a short summary of the causes for Renal cell carcinoma !
Renal Cell Carcinoma ( or RCC) is a common tumor of the kidneys and is essentially an Adenocarcinoma.
It's quite often called as the 'great mimic' as it is relatively hard to diagnose.
Here's the list of causes of this tumor.
Remember :
CCCC or C4
C = Cigarette smoking and Tobacco usage.
C = Chronic Kidney Disease / Cystic (Acquired) Disease of kidneys.
C = Cadmium, Asbestos and other occupational Exposures.
C = Cancer Syndromes.
Important Cancer Syndromes =
- Von Hippel Lindau Syndrome :
3p mutation in VHL Gene which is a tumor suppressor --> Tumors seen include Cerebellar and Retinal Hemangioblastomas , Pheochromocytoma, RCC (Clear type) and various other Cystic tumors.
- Tuberous Sclerosis
- Birt Hogg Dube Syndrome : Associated with various weird skin changes and chromophobe type RCC.
Skin changes include --> Tumors of Hair disc (Tricho-discoma) , Tumors of Hair follicle - Fibrofolliculoma and Acrochordons ( skin tags).
- Hereditary Papillary Cancer : Associated with MET Gene mutations
- Hereditary Leiomyomatosis with RCC : Associated with multiple Fibroids in the uterus.
That's all for today!
Hope this helped.
Happy Studying !
And, as always , Stay awesome !
~ A.P.Burkholderia
Friday, June 9, 2017
Step 2 CK: Differentiating ileus from SBO
Hello! Short post.
SBO: Small bowel obstruction.
Both: Nausea, vomiting, abdominal distension
Ileus: Hypoactive bowel sounds
Dull and constant pain
Dilated bowel but no air fluid levels
SBO: Initially hyperactive, later hypoactive
Colicky abdominal pain
Air fluid levels seen
That's all!
Back to studying.
-IkaN
Thursday, June 8, 2017
Neuroblastoma mnemonic
Hello!
The term neuroblastoma is commonly used to refer to a spectrum of neuroblastic tumors (including neuroblastomas, ganglioneuroblastomas, and ganglioneuromas) that arise from primitive sympathetic ganglion cells and, like paragangliomas and pheochromocytomas, have the capacity to synthesize and secrete catecholamines.
Remember the N myc mnemonic for neuroblastoma :
N - Neuroblastoma, N myc gene
M - Crosses midline (differentiates from Wilms)
MY - MYoclonus (Opoclonus myoclonus)
C - Calcifications in tumor present
C - Catecholamine secretion
You can also remember "High BP" for additional findings seen in neuroblastoma:
Horner syndrome
Heterochromia iridis (different colors of the iris or portions of the iris)
Hypertension
Homovanillic acid and vanillylmandelic acid elevated in urine
Bombesin positive
Back pain
Bone pain
Beckwith-wiedemann syndrome association
Posterior mediastinum or retroPeritoneal mass
Pseudorosette
Purple skin lesions
Proptosis
Periorbital ecchymoses
That's all!
-IkaN
Wednesday, June 7, 2017
Doyne's macular degeneration
So, the other day the head of my department asked us about Doyne's maculopathy. Couldn't find rest until I searched it up on Google. Here what it is in short-
1. Accumulation of material between
the Bruch's membrane and the retinal pigment epithelium.
2. This results into the formation of a drusen, which is a radially localised
white, large one which spreads over
time.
3. The cause is a mutation in the
EFEMP1 gene,on chromosome
2p16, inherited as an autosomal
dominant trait which results in the
formation of a misfolded protein
which is poorly secreted as well.
4. All this results into a gradual loss of
vision.
5. Photodynamic therapy forms the
mode of treatment for subfoveal nets which may also occur in the disease.
It is also known as 'Honeycomb retinopathy'
That's all!
-Sushrut Dongargaonkar
Tuesday, June 6, 2017
The Romberg's Test.
Hello,
Today's review is on Rombergs test.
Romberg/Brauch-Romberg sign:
In cases where the proprioception is disturbed, patient may be able to stand with eyes open but sways or falls with eyes closed.
Romberg described this test, in patients with tabes dorsalis where the Dorsal Columns are damaged.
Well he did not state that the feet should be placed together; it was added later.. Nor did he comment on where the arms were to be positioned.
It is just a common practice to have the patient hold the arms outstretched in front, in order to check simultaneously for pronator drift or to perform finger-to-nose testing; it is not what the original test was.
The Romberg sign is often misunderstood and misinterpreted.
The essential finding is a difference between standing balance with eyes open and closed. To test this function, the patient must have a stable stance, eyes open and then demonstrate a decrease in balance with eyes closed, when visual input is eliminated.
This is the time patient must rely on proprioception to maintain balance.
The Romberg sign is used primarily as a test of proprioceptive, not cerebellar, function, patients with cerebellar disease, particularly disorders of the vestibulocerebellum or spinocerebellum, may have some increase in instability with eyes closed, but not usually to the degree seen with impaired proprioception.
A patient with an acute unilateral vestibulopathy may fall toward the side of the lesion when standing with eyes closed.
Additional Manuevers for this Sign.
1) Ropper's Refined Rombergs Test :
Turning the head side to side eliminates vestibular clues and increases the reliance on proprioception.
2) The Sharpened Romberg Test :
It is done by having the patient stand in tandem position with eyes open and closed; the limits of normality for this variation are conjectural.
Hope this was helpful!
Let's Learn Together!
-Medha.
MCQ Pointers - Pityriasis Versicolor.
Hello!
If you see some of the below "pointer" words in MCQs the ans would most likely be pointing towards Pityriasis Versicolor.
-Acquired lesions.
-Hypopigmented small macules coalescing to form Patches classically on the chest (m/c),back,face.
-Perifollicular (around hair follicles) distribution.
-Fine scaling on lesions which becomes prominent on scratching - Scratch sign+.
-Pale yellow fluorescence of the lesions on Wood's lamp examination.
Finally the classic - Indicating the causative organism : Malasessia.
Spaghetti and meat balls appearance or Banana and Grapes appearance on KOH mount.
Lemme know more of pointers you know about.
Let's Learn Together!
-Medha.
Monday, June 5, 2017
Step 2 CK: Psychiatry tip for possible depression questions
Hope that helps!
GLP-1 analogues mnemonics
- Increase glucose dependent insulin release
- Decrease glucagon release
Sunday, June 4, 2017
Motor Neurone Disease : Why and How to rule it out.
Hi everyone ! Here's a short post on How and why to rule out Motor Neuron diseases.
Motor Neurone Disease includes a group of conditions where the Motor Neurons of your body begin to degenerate.
If these neurons are located above the level of the Alpha motor neuron of spinal cord , the result is UMN lesions , like Primary Lateral Sclerosis.
If the degeneration occurs in the Alpha motor neurons themselves , the result is LMN type paralysis, like Spinal Muscular Atrophy..
A combination of the two - UMN + LMN features as seen in - Amyotrophic Lateral Sclerosis.
Now a few set of conditions are used as a way to exclude to MND.
MND itself isn't very common , and carries an extremely poor prognosis. Treatment options are extremely limited. So it's important to rule it out whenever you come across a Paraplegia , Quadriplegia, Bulbar or Pseudobulbar palsy patient .
An MND has No COBS.
C - No Cognitive changes
O - No Ocular motility involvement till late.
B - No Bladder bowel involvement till late.
S - No Sensory involvement.
There are a few exceptions to this -
Cognitive changes can be present if it's associated with Fronto temporal dementia. A lot of the familial cases are associated with this.
Behavorial changes can also be seen in a Pseudobulbar palsy patient. (More on that some other day !)
Sensory involvement may be seen in Hereditary spastic paraplegia - a variant of MND.
So that's all !
Happy studying !
Stay awesome !
~ A.P.Burkholderia.