Canagliflozin (brand name Invokana)
Empagliflozin (brand name Jardiance)
Dapagliflozin (Farxiga)
Ertugliflozin (Steglatro)
Mnemonic: GliFlozIN makes Glucose Flow In Nephrons
Has beneficial effects on ASCVD events, heart failure, and CKD.
Causes weight loss (Mnemonic: SGLT2 Surely Generates Less Tummy).
No risk of hypoglycemia.
Genital fungal infections.
Fournier’s gangrene.
Dehydration may result.
Euglycemic diabetic ketoacidosis (should be held 24H prior to scheduled surgeries).
Canagliflozin may increase the risk of leg amputation (should be avoided in those with peripheral vascular disease).
-IkaN