Saturday, January 31, 2015

Study group discussion: Myopia and power mnemonic

Myopia (short sightedness) mnemonic, "Cave May Be Long"

CAVE - We use conCAVE lens
MaY - in MYopia
BE - BEfore image is formed before retina
LONG - eyeball eLONGate

When eye become Myopic it is acting as converging lens (+) convex lens (bend the rays coming from object the rays towards centre) more power more convergence more bending so we use diverging lens which is a concave lens to correct or to neutralise the bending or converging.

Concave lens negative (-ve) power.

Another study link! http://medicowesome.blogspot.ae/2013/10/myopia-and-hypermetropia-mnemonic.html

Study group discussion: Remembering Anatomy

Is there any easy way to remember the relations of the viscera?

Diagrams will help you remember the relations! There are a few mnemonics for arteries and stuff but in general, painting a picture in your head is the best way to remember!

Use Atlas for visualisation, see  videos of anatomy (Acland, Dalhousie) for awesome live experience... Highly recommended.

Seeing the viscera during cadaver dissection also helps in anatomy.

For anatomy, I find it helpful to draw the pictures out and label them. This allows you to appreciate the boundaries. 

I always drew diagrams in anatomy..Netter's helped a lot. 

Dissections are equally important...I  always read anatomy and revised it in my dissection class

Paroxysmal nocturnal hemoglobinuria mnemonic

Here's a mini post on PNH!

P: PIG A gene affected (On X chromosome that makes a glycosyl phosphatidyl inositol anchor)
N: Night. Hemolysis occurs at night.
H: Ham test confirms the diagnosis.

Patient presents with a history of dark coloured urine in the morning.

That's all!

-IkaN

Study group discussion: Succinylcholine

Can someone explain succinylcholine?

Succinylcholine is different than other neuromuscular blockers because it has two phases.

It is broken down in our body by pseudocholinesterase. And this enzyme differs in different people based on genetics. Hence, while using as a muscle relaxant it can prove quite deleterious to some people who have a weaker type of the enzyme.

Deficiency of pseudocholinesterase in some people causes succinyl choline apnoea.

Also, pseudocholinesterase is different than the more common acetyl cholinesterase enzyme.

Hepatitis B serum markers mnemonic

HBsAg: Surface protein of hepatitis B which means the person has infection presently. It's a marker for current infection.
Mnemonic: S antigen Stays in Sick patients (Active or chronic infection, negative in resolved infection).

Study group discussion: Difference between acute myelogenous leukemia and chronic myeloid leukemia

Good morning everyone! Just about to start studying some haematology. I can't seem to differentiate between acute and chronic myeloid leukemias.

The number of blast cells help you differentiate on blood smear! Blasts cells are present in acute myelogenous leukemia and are absent in chronic myelogenous leukemia.

Philadelphia chromosome too.

Ph +ve or -ve

The philadelphia chromosome in chronic, right?

Yep.

But there are some CML's without the chromosome.

The major difference in AML and CML is the mortality.
Death in AML occurs in 2 months is not treated, whereas in CML, it prolongs to 4-5 years.

CML has three phases..Chronic, accelerated and blast transformation.
In blast transformation, the patient's profile converts to AML and the prognosis is grave.

Basophilia in CML, classically.

Auer rods are characteristic of AML.

Most prominent cells in CML are myelocytes and metamyelocytes.

Thanks for the help everyone :)

AML is of seven types.

Study links!

http://medicowesome.blogspot.ae/2014/02/french-american-british-classification.html

http://medicowesome.blogspot.ae/2014/12/cml-treatment-mnemonic.html

Thanks!

Study group discussion: When dealing with a lesbian, gay, bisexual and transgender patient

Although talking about it, makes me wonder how all of you would handle an LGBT person if you saw one in the course of practicing medicine (And you probably will... whether you notice or not).

LGBT?

Why would it be different if you are handling an LGBT patient?

Lesbian, gay, bi- and trans*

Their sexuality may be a thing to consider but I doubt it should alter your duty to care.

Mostly if you're handling a trans* patient, actually.  Things like referring to them by correct pronouns (which sometimes won't match the gender listed on their medical records), or using a name they're more comfortable with, even if it's not their legal name.

I know a gynaecologist who refused to treat a gay, referred him to another doctor.

Right.  And intersex people.  That's kind of controversial as far as medical things go.  What would you advise the parents of an intersex baby?
Intersex as in a baby that isn't biologically male or female.
A lot of the time doctors will perform surgery on them to make their genitals more male or female.  But a lot of intersex people think that's a bad thing to do.

We had a girl come to our clinic for primary amenorrhoea.
She was later diagnosed as genetically male.
Intersex girl with amenorrhoea. She was 15.

Oh, that's kind of interesting.
Did she want male genitals?

I don't think she was given much of a choice. And as far as I know..People out here prefer a male child better.

That's a great share.

Hmm.  I'm sorry to hear she wasn't given much of a choice.  I hope she identified as male.

My bff is an LGBT.
We've been best friends for 10 years now, so I know how to treat an LGBT person: just like another human being.
They're actually very sensitive on how you call them.
I used to have a male patient that was in transition and she told me to call her: female transgender. She used to show me pics of herself modeling at the patients room and they were actually awesome.
I don't think people should treat other people differently because of their sex preferences.

I had seen a neurofibromatosis patient in the bus once. They were no place to even stand there..But even then nobody sat besides him..It was heartbreaking.

I think on one hand, treating an LGBT person is the same way you should treat any other person, but there are also some things that are different, like having to be careful about pronouns and gendered terms (for trans* people), or being careful about how you refer to their potential partners (i.e. not referring to future boyfriends when talking to a lesbian).

Also nonbinary people have a hard time, because they can't always access transition (because a lot of resources for gender dysphoria are for people who identify as male or female), and because their gender can't go on their medical records since very few countries recognise nonbinary genders (i.e. people who don't identify as male or female, but kind of somewhere in the middle, or they don't identify with gender at all etc.)

I don't think patients should be treated differently regardless of anything.  I think everyone should be offered the same standard of care, regardless of race, sexuality, gender or even things like mental health status (I strongly disagree with people not being given the same quality of health care for self-inflicted injuries).

Human beings are different from each other, yet so similar.... That is what makes humans so beautiful in their own kind of ways.

Intersex babies are often taken into surgery here (They mostly make them "more male", bc it's a patriarchal society and having a son is important). There was a major case in Cyprus a few years back, a surgeon operated on an intersex baby without fully informing the parents about the condition and/or their options. The whole deal was very ugly.

I've been actively working to improve the conditions of LGBTI patients here for years. I work with local and national Queer associations, and Turkish Medical Students' International Committee to teach medical students about the LGBT community, so that we can be more sensitive and we can help them out more. The society here is quite homophobic, so trans people can't access healthcare at all in some places. Only 2 weeks ago a trans acquaintance of mine passed away due to an infection after her gender-reassignment surgery because some of the hospital staff didn't take care of her. Very sad situation.

I'm a queer person myself (most people can't decide if I'm a man or a woman when they first see me) and that also brings about some funny conversations. Patients tend to not care though, as long as I have the white coat on, I could be a 6 foot lizard and they wouldn't mind.

Haha the 6 foot lizard bit!
I like how people are able to get through any situation with a good sense of humor :)

That's amazing..Hopefully one day the world will stop labelling people.. And consider everyone a human.

That's a feeling I get everytime someone is chastised for their choices..I just say out loud..Have you looked inside a human body? I have! And I know for sure we all are the same on the inside.

Well put!

Study group discussion: Diuretics

Which diuretic would you use in a person who has a previous history of skin rashes by the use of sulphonamides?

The only loop diuretic you can use in a patient with sulfa drug allergy is ethacrynic acid.
Also, you have to monitor the levels... Because ethacrynic acid is the most ototoxic.

There is an antibiotic that causes ototoxicity too. Which one?

Aminoglycosides!

Study group discussion: A question on ascites

Here's a exam oriented question I made up:

28 year old male presents with abdominal distension. Temp 37, pulse 92, BP 110/70, RR 18. On examination you find that he has hepatomegaly, ascites and his jvp is 8 cm above the sternal angle. Urinalysis is normal. He has history of alcohol abuse, had a viral infection few weeks back.

What is the cause of his ascites?
Urinary protein loss
Malnutrition
Liver disease
Portal vein compression
Thrombosis of hepatic vein
Pericarditis
Nephrotic syndrome

Discussion:

Liver disease?

Umm it's not liver disease. He would have symptoms of jaundice if he had liver disease.

Ohh, I thought hepatitis virus.

Pericarditis! The jvp and viral infection is the catch here.

Yes!

Nice question.. Hungry for more!

I almost thought it was viral hepatitis then I remembered that viral hepatitis shrinks the liver...Good question ..moore.

But what's the connection between pericarditis and the ascites!? Someone explain please!

Blood can't fill in the heart adequately during diastole, which causes an elevated venous pressure. It results in JVP, ascites etc

What's the answer to the case IkaN?

It's pericarditis.

Anyone wants to guess the etiology? Like what caused the pericarditis?

Alcohol abuse? Immunosuppression?

The alcohol abuse was intended to be a huge distractor. The guy simply had viral pericarditis due to Coxsackie B virus.

You have to assume Coxsackie because it's the most common cause of viral pericarditis.

I read somewhere that people who binge drink a lot are at risk of getting bacterial pericarditis..Streptococcus or Staphylococcus type..I didnt know about viral...It makes a lot sense though..Epidemiology rarely lies.

Oh I didn't know this. I know that alcoholics are predisposed to spontaneous bacterial peritonitis.

Yah its due to low immunity..another risk is in patients who have undergone pericardiocentesis.

Yes.

What is the mechanism of pericarditis?

Pericarditis is when there is inflammation of the pericardial sac. One of the many uses of pericardial sac is to reduce the friction over the heart with every heartbeat. There also can be collection of fluid in the pericardial sac.

It can be acute or chronic, and is usually classified by what the pericardiac fluid contains.

Extra hepatic complications of hepatitis C mnemonic

Hey!
A short post for today! :)

The mnemonic for extra hepatic complications of hepatitis C is, "ABC LMNOP"

Friday, January 30, 2015

Study group discussion: Eating disorders

Binge eating disorder is when the person stuffs himself in one day and then doesn't eat for a couple of days. In bulimia, patient eats normally / in excess but then voluntarily vomits out the food to avoid gaining from it.

Binging and then not eating  for a couple of days sounds like bulimia nervosa more than binge eating disorder.

People with BED don't compensate for their binges.  People with bulimia do (by restricting, exercise, purging etc).

Restricting is reducing caloric intake.   Purging can be making themselves throw up or by using laxatives.

Anorexics can also restrict and purge. But anorexics don't binge, definitionally.

So bulimics can be over weight, right? Because they binge? And anorexics are typically under weight? I always get the two mixed up!

Bulimics can be overweight or underweight, depending on how successful their compensatory strategies are after they binge (if they manage to throw up most of the food, and also exercise enough to compensate for the calories their body did manage to absorb, they can actually lose weight extremely quickly, like anorexics).

Anorexics are always underweight, definitionally.  If someone has symptoms of anorexia but they aren't underweight (or if they're female and they still have their period), then they'll probably be diagnosed with ED-NOS instead (specifically 'atypical anorexia').

ED NOS?

ED-NOS is eating disorder not otherwise specified.

If you recall, anorexia as a symptom and not a disorder just means loss of appetite (I really don't like that it's the same word).  So anorexia nervosa is a disorder largely characterised by not eating (although it's more complex than that, and a lot of anorexics do binge, just not frequently enough to be diagnosed with bulimia nervosa).

A person might also be diagnosed with ED-NOS if they have symptoms of bulimia, but don't binge often enough to be diagnosed with bulimia nervosa.

Up to 60% of people in eating disorder programs have ED-NOS.

It's also sometimes called OSFED (especially if you're not American).  OSFED is 'other specified feeding or eating disorder'.

I didn't know this about this. I thought Anorexia and Bulimia were the only ones!

So does the management of atypical Anorexia differ?

In the new DSM, the amenorrhea criteria of anorexia will be removed. 
So you still have a significantly lower weight than you should with anorexia, but you don't necessarily need to stop having your period anymore to meet the diagnosis.
Because many women even severly underweight can still have their period.
Also "binge eating disorder" is added, which is eating too much but without compensating behaviors.

But previously you had to miss your period 3 months in a row to have anorexia. They removed this criterium

Oh that's why I heard the no period criteria for the first time!

Yep it's new in DSM-V.

And as for the different treatment.. Since you are underweight in anorexia and not usually in ED-NOS, you will find more people with anorexia being treated by refeeding/feeding tube.

I didn't know that, but that's awesome.  It would be better if they removed the criteria for low weight, too, though. I know a lot of people in the pro-anorexia communities tended to want to wait until they met the weight and amennorhea criteria before getting help so that they could be diagnosed with anorexia nervosa instead of EDNOS.

Yep. It's an "honor" to have anorexia, "shame" to have EDNOS because you're not good enough at having an eating disorder and worse when you have bulimia.

It's strange they make a ranking system for eating disorders, while many people will fluctuate between all three disorders in their lifetime

Which is incredibly unhealthy, because:
1. EDNOS can be as physically damaging to your body as anorexia nervosa (bulimia nervosa is less likely to be physically damaging, although Boerhaave's syndrome, enamel erosion etc mostly only happen for bulimia).
2. Eating disorders, like anything else, are far more treatable if caught early.  Discouraging people from seeking help because the diagnosis they'll get is a less desirable one isn't helpful.

That's sad. The criteria shouldn't get in the way of someone who wants help.

I think the ranking system makes sense, though.  A really high percentage of people in the pro-anorexia community are perfectionists.  If the goal is to be skinny, having an eating disorder where the diagnostic criteria include being extremely skinny would be seen as relative success.  I don't think the ranking system is healthy in any way, but it makes sense.

As for bulimia being the worst... there's a pro-bulimia community, too... there isn't a pro-EDNOS community (although they tend to be absorbed by the pro-anorexia one).  So I don't think it's necessarily accurate to put bulimia at the bottom of the hierarchy (although I do realise that a lot of bulimics wish they were anorexic instead because they think they'd lose weight faster that way).

Hmm. So what do you guys think would be a sensitive way to approach eating disorders, in terms of clinical encounters or diagnosis? How might we be more body positive in the clinical setting?

Well it's hard to approach people with eating disorders properly... Because if they are still in denial (much like in addiction), they will see a comment about looking sick as a compliment

Someone asked whether the management of atypical anorexia is different.  In general, all restrictive eating disorders can be seen as fairly equal, and the recovery process is largely similar for anorexia nervosa and atypical anorexia.  The only significant difference I know of is that people with anorexia nervosa are more likely to be put in inpatient, and achieving a healthy weight tends to be more of a focus for anorexia nervosa than for EDNOS.

And yes, being told that they look sick would almost definitely be taken as a compliment.

I see. It's like they are different colors of the same spectrum.

I think what you can do is just ask the patient if they are okay, mentally. If they want to talk about anything, because you are worried.

I had a colleague this past week and she ate next to nothing, so I asked her. And told her if she needs to talk, she can e-mail or call me

Pretty much... I strongly disagree with the way they separate atypical anorexia from anorexia nervosa based on weight.  The psychological symptoms are the same, the mental distress tends to be the same, the treatment is the same, the potential physical harm that the eating disorders cause are the same.

Just never minimize the problem if your patient has an eating disorder, because they will try very hard to prove you wrong

A friend of mine has had people say to her that her eating disorder wasn't "that bad" because she wasn't severely underweight, which stimulated her to not eat. She ended up in the hospital. It's a sensitive subject, so try to get an expert to talk to them instead of potentially saying the wrong things.

I figured it was something like that. But expert aside, seems like it's still important to leave them to open the conversation, similar to any other mental illness and let them talk it out than seek immediate referral.

Definitely :) if you are willing to help and listen, just tell them that you don't know much about it/don't have experience treating people with eating disorders, but you would like to try and help.

As far as being sensitive goes:
1. If a blood test and/or an ECG is part of the diagnostic process (I know it's a requirement for the eating disorder treatment program here, I don't know if it is elsewhere), assuring someone (especially if they aren't thin enough to be diagnosed with anorexia nervosa) that even if the blood test results look 'normal', it doesn't mean that they haven't done damage to their body, and it doesn't mean that they aren't sick enough to deserve help (this is especially true for people who are voluntarily seeking help for an eating disorder).
2. Not telling people to just eat... I don't know why on earth people, including medical professionals, insist on doing this.  It's awful.  Don't.  If it was that simple they wouldn't need medical treatment.
3. Acknowledging that the eating disorder serves as a useful and valuable coping mechanism.  Even though eating disorders are their own special kind of hell to have, the feeling of control they give to people who suffer from them can still feel good and make it hard to recover.  It's possible to be sensitive and acknowledge the things that make it hard to *want* to recover, while still pointing out that on the whole, it's harmful, and recovery would make the patient's life better.
4. If someone has atypical anorexia, don't constantly remind them of it.  They probably think about it a lot.  Saying "eating disorder" validates the severity of what they're going through, and emphasises that all eating disorders are serious and should be treated as equally serious.
5. Unless their life is in immediate danger, don't try to force recovery-oriented behaviours on them.  Let them recover on their own time: it'll make it so that the recovery process is less scary/unpleasant, and will also make it so that their recovery lasts longer.  Eating because you've been forced to isn't the same as eating because you want to recover.  Encourage them to choose recovery on their own.
6. Following on from that... don't just focus on the physical symptoms.  Yes, it's important that people figure out how to eat properly, because not eating properly can result in very serious physical consequences, but it's also very important to acknowledge the mental symptoms, because those can cause very serious effects on the person's quality of life, too.  A friend of mine saw a psychiatrist for anorexia nervosa, and the psychiatrist kept focusing on her weight, and as she reached her healthy weight, the psychiatrist acted as though that meant she was nearly recovered.  Never forget that eating disorders are mental illnesses, and just because someone's at their healthy weight doesn't mean they're recovered, or that they don't still need help.

I have mixed feelings about handling co-morbidities, because I don't know a lot about them.  I know that there are segments of the medical profession who believe that if someone presents with a comorbid eating disorder and anxiety/depression, that they'll try to treat the eating disorder first before doing anything about the anxiety/depression.  Which to some extent makes sense, because not eating can do weird things to mood, but I personally don't really like that approach (especially in cases where the anxiety/depression clearly was present before the onset of the eating disorder).  I do know, however, that if a medical professional takes the view that the eating disorder should be addressed first, it can definitely come across as them dismissing the mood and anxiety disorders as being just a by-product of the eating disorder, which can be incredibly invalidating.

I feel anxiety & depression should be addressed along with the more obvious eating disorder. But I don't know if it's feasible in clinical practice.

You can ask the patient to talk about it, sure. But if that doesn't work pharmacological treatment takes weeks. And you never know if the eating disorder caused the depression or vice versa, the depression caused the eating disorder. I really don't get how a psychiatrist would actually approach and manage such a patient.

Comorbidities are messy.  Eating disorders tend to make anxiety/depression worse, but anxiety/depression (especially anxiety) can make eating disorders worse, too.  In light of that, I feel as though treating them both at the same time makes sense because reducing the symptoms of the depression/anxiety might make the eating disorder better, even if the eating disorder is the cause of the depression/anxiety.

I know there are psychiatrists who will prescribe antidepressants and/or anxiolytics for people who have eating disorders.  But also doctors who insist on treating the eating disorder by itself first. I don't think there's a general consensus on what's the best way to handle that.

As for feasibility in clinical practice, I personally think it makes more sense to address depression/anxiety at the same time as the eating disorder, especially where it isn't certain whether any given symptom is caused by an eating disorder or anxiety (if someone's afraid to eat in public, is it general social anxiety or the eating disorder?... there's no real way to tell... but it's not important, because either way the symptom needs to be addressed)

Agreed.

Would it help treating an anorexic patient indirectly?  Say, you need to gain a little weight back even though you might not like it because.. Idk.. You have amenorrhea? And that's bad etc etc
Or is that even allowed?

Anorexic patient: I doubt it would help.  At a fairly early point in eating disorders, the desire to be thin begins to take on an irrational level of importance.  It's not uncommon for anorexic patients to express the idea that they don't care if they die, so long as they can die skinny.  Although in the early stages of illness, a lot of anorexics desire to be skinny so that they can be beautiful, or popular etc, at some point it often takes on an importance of its own, and they'll be willing to risk everything (health, beauty, popularity etc.) to be skinny.  When it gets to that point, curing amennorrhea isn't really going to be enough of an incentive to overcome the obsessive desire to be thin.

Even if they gain back the weight, you might end up in a yo-yo weight situation where any underlying disorders keep cropping up, particularly in times of stress. Eating disorders tend to be chronic and long-lasting.

Telling someone that something they do is "bad" also probably isn't really compelling, even though lots of people try that tactic :p

That is also true.  And as I said before, although gaining back the weight can be important, it's even more important to deal with the underlying mental illness.

So, it would still be difficult to show them that hey! You are back to normal weight and still looking good? As in their perception just won't change?

Once people get close to being at a normal weight, they often feel that they look incredibly fat (and in comparison to their emaciated bodies they had while severely underweight, they probably do).

I guess it makes if I think according to their thoughts.

There was an experiment where people were starved and they started engaging in disordered eating behaviour, but once they reached their healthy weight again the disordered behaviour went away.  The problem is, that only seems to be true for people who developed disordered eating behaviour after losing weight.  For people who lost a lot of weight as a result of disordered eating, regaining the weight doesn't seem to usually fix the problem.

Which is why I so strongly disagree with any treatment approach that focuses on regaining a healthy weight, and using weight as a marker for how healthy a person is.  Because if someone recovers enough to be at a healthy weight but doesn't recover fully mentally, chances are they're going to revert back to old behaviours again.  Relapse and recovery cycle and all that.

Full recovery is generally possible for restrictive eating disorders, in that a lot of people never do go back.  But that only happens if the underlying eating disorder is adequately dealt with, and not when the only recovery that has happened is weight restoration.

It falls to dealing with the cause versus dealing with the symptoms.

Precisely.

So if we don't talk about weight, how do we bring them back to a normal mental state?

Well the mental state is the problem the weight is just a visible symptom of that.

Eating disorders are often very helpful to people who have them, even if they cause a lot of suffering.  They're a way of being able to exert control in a chaotic world.  It's why eating disorders are so common among young people with controlling parents.  Eating can often be the only thing that people can control if they live in highly restrictive environments.

So changing how you think about the illness is an important first step?

To that end, making sure that people with eating disorders find things in their life that they can have control over in healthy ways can be really valuable.

Many associate these with vanity which undermines the sickness.

It has a stigma sort of like depression, where it used to be considered that the person was just sad or moody but now we know it is an imbalance of neurotransmitters that is the cause.

It's important to take. the patient seriously and treat it as a real illness so that the patient can feel that they can be cured and recover, like most illnesses.

Definitely acknowledging that it's a real medical illness and not just something someone is doing to themselves is important.  Validating someone's experiences is one of the most important things about dealing with patients, and especially important in cases of mental illness.

Validating that's the word.
Couldn't for the life of me recall it.

One more question, mentioned that one way would be to make sure they have control over other things in life in healthy ways. What exactly do we mean- lifestyle?

If they're a child, ask their parents to give them more freedom to make choices in their life.

If they're an adult, talking to them about the areas in their life where they feel they have no control, and helping them see that they do actually have quite a lot of control can be helpful.

Although that can be tricky, a lot of people with eating disorders have been victims of trauma, and that's very much a situation where they did not have control.

I see. This was incredibly insightful. Thank you guys!

You should also try to focus on giving them better coping mechanisms and expressing their feelings. A big part of eating disorders is also about not feeling, not dealing with emotions. They need to know it is okay to cry, that they can deal with whatever caused the disorder in a healthy way. And especially let them know that yes, even though this coping mechanism was helpful in the past (for example in cases of abuse), it is no longer necessary to survive.

It makes me really happy that people in this group were so willing to listen when we were talking about what to do with patients who have eating disorders.  And your desire to make a difference when you're in clinical practice.  I like how everyone in this group seems to genuinely care about being a good doctor and to care about patient welfare.  I think that's really important, and it makes me hopeful about the future generation of doctors to see how much you care.

Study group discussion: Osler Weber Rendau syndrome

I had once taken a case of Osler Weber rendau syndrome.

It's an autosomal dominant disease..Where AV malformation occur throughout the body.

The case i had was of a 26 yr old lady G6P3L1D2A2
And in her most recent pregnancy, during her 24th week.. She had sudden onset cough and breathlessness.
Later on pulmomary tapping..Blood was withdrawn.

The AV malformation in her lungs had bursted. She was taken for surgery.

Which surgery?

I forgot the name of it. Under angiographic control, the bleeding is sought out and the bleeder clamped.

The baby was taken out by C section at 37th week..Cause it was having an IUGR lag of four weeks.

But from what I reserched was angiogenesis occurs our entire life time.
So as you grow the number of av malformation go on increasing.
In children it presents as epixtasis.
In young adults..bleeding in lungs.
As you grow they may rupture in the brain as well.

I had a case of Osler Weber Rendau syndrome who presented with Haematemesis.
The attending told us to suspect it in patients who do not have signs of liver cell failure (Since portal hypertension is the most common cause of Haematemesis!)

Study group discussion: Reason behind names of oral contraceptive pills and retroalimentation

I remember in my obstetrics practical.. I was asked why the name mala was used for mala-D or mala-N. These are oral combined contraceptive distributes free in India.
Anyone from India knows why?
I tried searching online.. Didn't find the reason why!

Mala means garland in Hindi. I have no idea why they would call a contraceptive a chain of flowers or beads though!

I am not sure but i think something like mala pearl and it's importance?
Mala N and D have other names like moti, pearl.

This Mala n and mala d is a garland like with beads equal to number of days in a month.

The mala D thing you asked... The backside of the packet shows the pattern in which they're supposed to be taken... That looks like beads in string... So may be that's why the name...

Makes sense.

Yes, but they can inhibit the synthesis of sexual hormones. If used for prolonged time, it makes harder for a woman to get pregnant after stopping them. They're very effective though.

Hmm.. I never read anything like that.

Read about retroalimentation of sexual hormones.

What's that?

If they are taken orally, the body stops producing them normally. They have a negative retroalimentation, meaning that if theres estrogens in the body, other glands will notice and they wont produce it naturally. Hormones have a whole organ-brain system of production.

So that's bad?

No, not bad.
Doesnt mean they'll be sterile.
Just means itll take time for the body to produce them naturally again.

I've read that if woman take hormonal therapy they have more propensity to get endometrial cancer.

Yeah, that's why progesterone is added.