Sunday, March 4, 2018

Stroke Series: Cortical lobar functions

This is a basic post on our stroke series -
CORTICAL LOBAR FUNCTIONS.

1. Frontal lobe:
Okay guys, for frontal lobe, I think of an average guy (not the musician, not the good looking) trying to get a relationship - well, that's were you need your frontal lobe for.

• Personality - definitely, it's one of the prime qualities an average guy should have.

• Flirting skills - Social behaviour and language.

• Emotional control - you have to have good emotional control even if you fail at it multiple times.

• Other functions are Motor and Micturition.

2. Parietal lobe:
It has dominant as well as a non dominant side. For the dominant side, think of a calculator and for the non dominant side think of playing Tetris video game.

• Dominant side - Calculation and language.

• Non dominant side - Spatial orientation and constructional skills  (Tetris game).

3. Temporal lobe:
For the temporal lobe, it has both dominant as well as non dominant side. For this, you have to think of the position of temporal lobe near your temples, near which you have your ears, mouth and nose and for the non dominant side it's the musicians area.

• Dominant side - Auditory perception and balance, Smell, Verbal memory, Language.

• Non dominant side - Melody, Pitch, Non verbal memory (musicians remember music, not words, it's a weird way to remember!)

4. Occipital lobe:
O looks like an Eye to me O_o for vision.

    • Visual processing

That's all!

This is a basic post. I'll come up with a detailed one soon. Enjoy studying!

The Stroke Series is written by our Medicowesome Student Guest Author, Nikhil. More to come soon!

Friday, March 2, 2018

How I scored a 258 on USMLE Step 1

I scored a 258 on the USMLE Step 1 a year back!

How I prepared:

I studied for a total duration of dedicated 6 months. I used following resources:
-Google/Youtube/wikipedia (my prime educators)
-FA 2016
- uWorld offline 2016 (was tight on my budget so didn't buy online)
- BRS pyhsio (only did renal, body fluids and Acid base)
- BRS behavioural (only for devlopemental milestones, physician patient relationship, medicoloegal/ethical issues, healthcare delivery and epidemiology/biostats)
- High yield biostats (only for study designs, bias, probablities and aplha/beta concepts)
- BRS genetics (only for population and hardweinberg genetics)
- Shelf notes (anatomy)
- Beckers anatomy (only for selected topics in neuroscience [didn't do entire neuroscience], upper and lower limb)
- Beckers immuno/micro (for immuno and bactrial/viral  genetics [didn't do entire micro]
- DIT 2015 (short and precise, found it effective atleast for me)
- Kaplan 2014 video (only for pharma)
- NBMEs ( all of them)
- Kaplan Qbank offline (only for genetics, pathophysio and pathology)
-Goljan audio lectures

I started my prep with offline uWorld, did all the questions according to systems and used it solely as a learning tool.

Meanwhile, I was also using DIT, FA, Goljan audio lectures and NBMEs

- How did I use offline uWorld?

According to systems (first did all the questions of particular system followed by explanations with read of relevant topics in FA [This is how I integrated all the scattered topics in FA relevant to that system], I never read FA cover to cover but with this strategy I was going through the same topic many times.

Advice: Make seperate notes of UW acc to systems rather than annotating it on FA, clean FA really helped me in the end.

- How did I use audio/video stuff?

Parallel with UW and FA (It didn't take long, since DIT videos were short and oriented to FA. Goliyan audio lectures were also short. Kaplan pharmacology lectures I watched in  x1.5 speed [I really can't sit for straight 4 hours :D ])

- How much time all this took?
UW with FA and audio/video stuff took 4 months.

- When did I start NBMEs?

I started them right after after 1 month of starting UW & FA (first I needed to figure out what topics were  being tested and to what extent [though USMLE site gives info on it but you only get to know it when you start doing NBMEs], then I  focused on HOW CONCEPTS were tested rather than what concepts were being tested. By this type of analytics you get general idea of predicting different ways a concept can be tested.

Advice: Please start doing NBME early in your prep, all the NBMEs asess your baseline knowledge in different ways. So if used properly NBMES can be a learning tool aswell as an assessment tool.

Opinion: In my view NBME 12, 16 & 18 were closest to my exam (real exam was a beast but that doesn't mean its not doable). For me NBME 12 was an eye opener, it really fine tuned my Q approach and provided guidance on what areas to work on. It is after this NBME that i was able to push my scores beyond 180/200.
Note: I used NBME 1-11 for learning, practice and analysis.
NBME 12-18 I used for asessment.

- What about last 2 months?
In last 2 months I did assessment NBMEs (was doing it at every one week interval, in btw interval I was doing FA + my notes, read relevant topics from resources I mentioned in part#1, did kaplan Qbank questions and also BRS Qs (questions given in the back of each chapter and at the end of book) so one week before exam I was done with all the NBMEs.
- NOT TO MENTION THAT I was GOOGLING/YOUTUBING all the time during my prep...lol :D

- My NBME scores:
  Nbme 12 -178/200
   Nbme 13 - 190/200
   Nbme 15 - 188/200
   Nbme 16 - 183/200
   Nbme 17-  186/200
   Nbme 18 - 259 (online)
   Real deal - 258!

Advice: Before your exam do 2 NBMEs or UWSA 1 and 2 in a row in one day to practice endurance, because in my experience fatigue almost killed my concentration  in 6th/7th block.

Feel free to ask questions.
Study hard and smart.
Good luck everyone :)

Written by Ammar Mushtaq

Save lives, Donate blood.

Blood Donation

Facts about blood donation
1.     There’s 10 pints of blood in the average adult body (1 pint = ~473ml)
2.     1 pint of blood can save 3 lives
3.     Type O- can be transfused to patients of all blood types
4.     Red blood cells can be stored for 42 days
5.     Platelets can be stored for 5 days

Eligibility requirements
1.     18-60 years old
2.     Free from medication and alcohol (avoid alcohol a day before donating)
3.     Healthy (physical & mental, free from chronic disease)
4.     Sufficient sleep ( >5 hours ) before donating
5.     Does not involve in high risk activity (drug intake, multiple sex partners)
6.     Not pregnant, not during menstrual cycle

After donating
1.     Avoid strenuous activities
2.     Drink plenty of fluids
3.     If you feel dizzy, lie down with both your feet raised above head level

Frequently asked question
1.     How long will it take to replenish the pint of blood I donate?
-Red cell – 4-8 weeks
-Plasma – 24 hours

2.     How long should I wait till my next donation?
-Men – Once in 3 months
-Women – Once in 4 months

3.   Reasons to donate my blood?
      -Save life (accident victims, burn victim, patient who need surgery, dengue patient)
      -Reduce risk of heart disease
      -Replenishes blood cells
      -Weight loss
      -Free health check-up (please donate with the heart of saving lifes, not for the sake of free health         check-up)


You can save 3 lives just under 60 minutes, so why not? :)
-
Calvin Ong K. Y.

Tuesday, February 27, 2018

Oxytocin

OXYTOCIN

Hello Awesomites! Here's a collection of important facts about the love hormone oxytocin.

Oxytocin sensitivity is increased during delivery.

In lactating women genital stimulation enhances oxytocin release.

Oxytocin challenge test for assessing fetal well being is contraindicated in - Placenta previa
Previous two LSCS
Premature labour

Posterior pituitary secretes Oxytocin.

Oxytocin causes Milk ejection, Contraction of uterine muscle & Myoepithelial cell contraction.

Post partum hemorrhage, Uterine inertia & Breast engorgment due to inefficient milk ejection reflex are indication for oxytocin.

Side effect of oxytocin are Placental abruption, Fetal distress & Water intoxication.

Oxytocin is synthesized in Hypothalamus.

Oxytocin is a Polypeptide.

Oxytocin is Secreted in both sexes.

Oxytocin is an example of neurohormone.

Atosiban is an Oxytocin antagonist.

-MD Mobarak Hussain (Maahii)

Types of meshes for hernia repair

Hey everyone, I've just started surgery, and realised that I love the subject! The first topic I started reading was the most commonly read one: hernia!

I realised something very interesting- hernia repair using meshes is a pretty difficult thing to do, because you need to find the right mesh for a particular type of hernia. This is a very dry topic but an important one, so I've tried to add some tricks to remember stuff about meshes!

Q. What's a mesh?
A. A mesh is usually a sheet which has been perforated to make very tiny holes in it, hence it could either be a net or a flat sheet. A mesh is supposed to have a good overlap over the area of defect, and it's margins should cover greater than 2 cm but less than 5 cm of the area with defect.

Q. What are the functions of a mesh?
A. 1. Bridge a defect, to form a tension free patch over the area.
2. To plug a defect if it is small and overlap is hard to achieve.
3. ‎Augment a repair by reinforcing it with the support of this mesh.

Remember it as: BPA (Bridge, Plug, Augment).

Q. Does a mesh cause complications? Which ones?
A. Although an amazing treatment for hernia, it does have its set of complications.
- Mesh plugs can cause meshomas which is a plug of the mesh substance and collagen which will grow over it. -‎migration of the mesh from its original place
-‎ Erosion of surrounding organs
-‎ Fistula formation
-‎ Chronic pain

Remember it as: Growth of a meshoma, pushes upon the surrounding structures causing erosion, eventually it grows so much that the mesh is pushed away (migration), eventually it grows so much it forms a hole (fistula) which obviously causes pain!

Q. How does a mesh work?
A. Net meshes allow fibrous tissue to grow between its strands and become adherent. This integration happens within few months. The initial fixation hence is by means of absorbable material such as glue, sutures or staples.

On the other hand, sheet meshes do not allow such growth between its strands, but gets encapsulated with the fibrous tissue.

Types of Meshes:
1. Synthetic Polymers: polypropylene, polyester, polytetrafluoroethylene.
These are non absorbable and provoke little tissue reaction. As polypropylene has strong monofilament mesh they will have no antibacterial properties, hydrophobic in nature and the monofilament nature impedes growth. Polyester has braided filament mesh and is hydrophilic in nature which hence allows rapid vascular and cellular infiltration.

Features of synthetic meshes:
- Very strong
-‎ Provokes fibrous reaction
-‎ More heavy hence more tissue reaction
-‎ Mesh shrinkage causes progressive decrease in size of mesh over time, leading to tissue pain and hernia recurrence if the defect is not covered fully by shrunken mesh.

2. Biological Meshes: Materials used are usually human or animal dermis, bovine pericardium or porcine intestinal submucosa. These are sterilised, decellularised, non immunogenic connective tissue materials. It has a scaffold structure upon which enzymes work to break down the biological implant and replace and remodel with host fibrous tissue. It's expensive.

3. Absorbable Meshes: polyglycolic acid is a common material. It is for temporary abdominal wall closure.

4. Tissue Separation Meshes: Polycellulose and collagen are widely used. these are for intraperitoneal use, their one side is sticky and the other is slippery. These have good adhesion, with host tissue on parietal side of mesh using the sticky side, and the other side, the slippery one, needed to prevent adhesion is on the visceral side.

There are a lot of Polys here. Let's try remembering which one is under which type?

Ester, Propylene, Tetrafluoroethylene: sound like fake names, so will probably be synthetic!

Glycolic acid is used a lot in skincare products, especially soap. Soap is absorbable, hence a mesh made out of it will also be absorbable, right?

Cellulose and collagen used in the 4th type of mesh are naturally available materials. So can be definitely used for intraperitoneal procedures! Hence can be used in tissue separation!

FactFatigue: Meshes greater than 80 g/ sq m are called heavy meshes. Those less than 40 g/ sq m are called light meshes and are preferred in surgery.

Hope this was an interesting and easier way to remember hernia repair!

This awesome post was written by Devanshi Shah

Monday, February 26, 2018

How I scored a 270 on USMLE Step 2 CK

Hey everyone!

My friend Ammar Mushtaq just got done with his CK and scored a brilliant 270. Here's what he has to say about this prep. Take it away Ammar:

Done with my CK it's a 270!

Kudos to my family , friends, and anyone who was involved during my prep for all the support.

Kudos to the guy/girl who compiled the offline uWorld 2016 (hats off to you!)

Kudos to the guy/girl and members of his/her facebook group who uploaded CMS/NBMEs with answers and explanations.
Update: There was a CMS group on Facebook where IkaN had copy pasted UpToDate explanations for CMS questions. IkaN loves UpToDate and that group was very helpful. Unfortunately, it was deleted by the admin :(

Kudos to IkaN for UpToDate access.

My preparation:
6 months of total prep. After 3 months of prep, I was supposed to give my exam. I had decent assessment scores and IkaN thinks I could've given it then and still scored a 270. However, due to terrible anxiety, I postponed my exam for another 3 months. It's really hard to sleep and poop in the last 3 months xD

I started directly with offline UW subject wise and did it slowly but for once only (for me repeating the same thing weakens my reflex and ultimaltely, I end up paying less concentration). I did not make any notes, all that highlighted on offline UW PDF were basically my notes.

With 60% of UW done, I started doing CMS and NBMES (NBME 7 - 25 wrongs, NBME 4 & 6 - 13 wrongs, NBME 3 - 24 wrongs) with aim of learning and not assessing my self. I did all of them offline and in timed mode.

I read MTB 2 once not to cover facts and figures but to see what Conrad wanted us to think. In the end, I experimented with few Kaplan and Rx questions but soon gave up because of poor wording and because the questions were not designed to make us think on multiple levels as UW and CMS questions are.

I used to Google images all the time - x-rays, physical findings, etc. I think that helped a lot too.

I solved psych, stats and ethics of UW step 3 too. The frustration and anxiety led me to solve step 3 NBME in step 3 groups. I went nuts basically :P

Exam day: 
Exam was a tough beast, it's a mix bag UW and CMS/NBME concepts (DON'T neglect them) - you can not blindly use UW logic for every question.

Time was issue for me, so I missed 3 Qs on exam just like in UWSAs. Exam is all about time strategy and gaining points on common concepts because 15-20% of exam topics are way beyond our reach (at least for me) so all you can do is to make an educated guess and move on instead of dwelling on those Qs.

Stem lenghth ranged from mix of lengthy, medium and 3-4 liners. Devise your own strategy (Mine was to read the Q from start till end), to read the options once because you cannot afford to lose time.

Don't bother about drug ads and abstracts, they will be time consuming and can be tricky so do them at the end of block.

All in all, you will be able to do 75-80% of exam with UW and CMS/NBME.

UWSA 1 > 270 one month before exam
UWSA 2 > 260 one month before exam

Good luck!

Written by Ammar Mushtaq

Q&A with IkaN: I basically interviewed the poor guy till he got fed up of me.

I: For baseline purposes, what's your step 1 score?
A: My step 1 score is 258.

I: Did you revise step 1 before the exam? If yes, what did you read?
A: I did a lot of Googling on the web, Image searches and Youtube studies during my step 1 which  helped me in step 2 as well.

Around 10-15 questions are similar to step 1 but they are doable. FA should be enough for revision.

I: Do you think a big gap in between step 1 and CK makes a difference in score?
A: I don't think so, I had a 1 year gap approx.

I: What makes a 270 really? Everyone does UW and CMS.
A: I did all my CMS and NBME with intention of knowing the question writers perspective and that's really what I think made a real difference in my performance.

I: How many hours per day did you study for the 6 months you prepped?
A: I could not study 8-12 hours per day, at most 6 hours a day, that is why it took me 6 months.

Can you share your study time line?

I did UW only initially. I did it slowly, at a very comfortable pace because first encounter with the concept/knowledge is the one that is everlasting.

With 60% of UW done, I started doing NBMES every week and doing CMS in between. Never make your self slave to the thinking, "Once I am done with everything from UW and books then I'll start assessments."

No, don't do that because unless you know how boards will ask a concept, you will not know what to look for when you study.

I: Besides UW, which sources did you do for Biostatistics?
A: High yield biostatistics is gold building foundations for statistics and I did that during my step 1 prep.

I: Does MTB really help?
A: Yes, I would advise people to read it as it is not a great deal of content to cover.

I: How did the study groups on Whatsapp help?
A: Study groups on Whatsapp and Facebook really helped me but they were very anxiety provoking. Proceed with caution :P 

I: What kept you going on the rough days?
A: The American dream; people like Kanye west, Timberlake, Adam levine, Zara larson etc; tourist spots such as Miami and LA kept; the bond style martini kept me going lol.
I: HAHAHAHHAA

And Ammar shared a glimpse of his playlist:

Kanye West - Stronger
https://youtu.be/PsO6ZnUZI0g
This was quite motivating

Friction By Imagine Dragons (Mission Impossible Fallout Trailer Music)
https://www.youtube.com/watch?v=bmUxvX2z5N0
This was recent addition in my motivation list

Kanye West - Heartless
https://youtu.be/Co0tTeuUVhU
This perfectly describes my feelings right after exam and before the result was out 😂😂😂

Thank you so much, Ammar! :)


Menopause

Menopause : Facts

Gonadotrophins remain elevated after menopause for rest of life.

Average age range of attaining menopause is 45 - 55 years.

A 35 years old lady is not having her menses for last 4 months. She has high serum FSH and LH level with low estradiol. The likely cause is Premature menopause.

Predisposing factors for endometrial carcinoma is late menopause.

Carcinoma vulva is seen in seen after menopause and viral predisposition.

There may be an increase in FSH secretion by the pituitary gland in menopause.

Systemic vasomotor instability may be present in menopause.

There is a decrease in skin elasticity after menopause.

The symptoms of menopause are best treated with Estrogen.

Late menopause is risk factor for breast cancer.

Osteoporosis is seen in menopause High progesterone, High estrogen & Low FSH are seen in menopause.

Menopause may cause prolapse of cervix.

-MD Mobarak Hussain (Maahii)

Step 2 CK: Treatment of hypertensive emergencies

Drug of choice for hypertensive (HTN) emergencies

1) In aortic dissection: Beta blocker eg labetalol (because all other vasodilators will cause compensatory tachycardia)

2) ‎In malignant hypertension, HTN urgency, HTN emergency in a non pregnant adult: Nitroprusside is the first line drug.

3) HTN emergency in pregnancy: Hydralazine or Labetalol or Nifedipine (Mnemonic here)

Submitted by Disha Sharma

Step 2 CK: Confusing vesicular skin manifestations

Skin manifestations that sometimes confuse us:

1) Dermatitis herpetiformis: It is a skin manifestation of celiac disease (adult and pediatric) - clusters of vesicles, pustules on extensor surfaces of elbow, knees etc.
Treatment:  Gluten free diet and anti-inflammatory drugs (Dapsone, Sulfapyridine)

2) Eczema herpeticum: Infection of eczematous skin by HSV (fluid filled , honey crusted vesicles on red, indurated skin of eczema).
Treatment: Acyclovir, Valaciclovir.

IkaN addition: I know honey crust makes us think of impetigo right away but put the presentation and distribution whenever inferring the diagnosis. I've got a number of questions wrong on the USMLE practice tests because of the honey crust bias.

This mini note was submitted by Disha Sharma :)

Saturday, February 24, 2018

Urinary Bladder and Clinical Correlates

Hello everyone! This write-up attempts to organize the seemingly confusing nerve supply of the bladder and associated pathology aka the neurogenic bladder.

NERVE SUPPLY :


(beta 2 and alpha 1 are adrenergic receptors of SANS ; muscarinic type 3 is a cholinergic receptor of PANS)

  • SANS inhibits micturition while PANS facilitates micturition. You don’t want to pee when you’re running a 100m sprint, an SANS-dominant activity but you can comfortably pee at rest, a PANS-dominant activity.
  • Sensory fibres of pudendal nerve tell your CNS when the bladder is full. The motor fibres of pudendal nerve maintain EUS tonic contraction by default so that you’re not always peeing.
  • The reflex arc, after higher centre commands, causes voluntary micturition by inhibiting the “contraction-effect” of motor fibres of pudendal nerve.
  •  To oversimplify matter (so that it’s easy to understand and remember): Level 2 control inhibits reflex arc. Level 3 control facilitates reflex arc, causing micturition at will, once the bladder is full.


CLINICAL CORRELATES:


  • CORTICAL BLADDER
-- Aka Incomplete Spastic OR Uninhibited bladder.

 LESION
CLINICAL  FEATURE
Postcentral cortex
         --  Loss of awareness of bladder fullness
         --  Incontinence
Precentral cortex
         --  Hesitancy = Difficulty in initiating micturition
Frontal cortex
         --  Precipitancy = micturition with ‘easy’ stimulus, eg: sound of running water
         -- Inappropriate micturition/ loss of social inhibition (infant-like)

Associated with:
Multiple Sclerosis
Parkinson’s disease
Stroke, among others.

  • HYPERTONIC/ AUTOMATIC  BLADDER
-- UMNL/ Complete spastic type of bladder.

LESION
CLINICAL  FEATURE
Spinal cord ABOVE S2, S3 and S4.

        --  Urge incontinence = patient passes low-volume urine frequently
        --  Less post-voidal urine volume, so less risk of UTIs
        --   More intra-vesical pressure, more risk reflux nephropathy

  • HYPOTONIC/ AUTONOMOUS BLADDER
-- LMNL/ Flaccid type of bladder.

LESION
CLINICAL FEATURE
        --  Spinal cord AT S2, S3, S4
        --  Cauda equina/ Conus medullaris
        --   Peripheral nerves

        --  Overflow incontinence =  urine retention, overtime, forces IUS to mechanically open causing dribbling micturition
        --  More post-voidal urine volume, more risk UTIs



2 subtypes are:
  • Motor Paralytic bladder – Motor (efferent) pathway is damaged. However, patient can sense bladder fullness, resulting in prompt diagnosis. Associated with:
--  Complication of abdominal/ pelvic surgery
--  Lumbar canal stenosis
--  Lumbo-sacral meningo-myelocele
  • Sensory Paralytic bladder – Sensory (afferent) pathway is damaged and hence, patient canNOT sense bladder fullness, resulting in delayed diagnosis. Associated with:
--  Diabetes mellitus
--  Syringomyelia
--  Tabes dorsalis

Medicine pearlWhen we talk about bladder pathology, we only refer to PANS (lesions above/ at/ below it) as SANS lesions doNOT cause bladder pathology per se. However, bilateral lesion to L1 causes retrograde ejaculation and hence, infertility.

Topics for further reading:
--  Age-related urine continence
--  Nocturnal enuresis
--  Barrington reflexes


Hope this helps! Let me know if anything needs clarification. Happy studying!
-- Ashish Singh.

Tumor lysis syndrome and rhabdomyolysis: Why does calcium decrease?

Doubt in response to you post on tumor lysis syndrome: What is the mechanism behind hyperphosphatemia causing hypocalcemia in tumor lysis syndrome? Wouldn’t the tumor cells also release calcium, thus leading to hypercalcemia? Asked via email

Friday, February 23, 2018

HPV vaccines

Hello Awesomites!

HPV infection can cause:
-cancers of the cervix, vagina, and vulva in women;
-cancers of the penis in men; and
-cancers of the anus and back of the throat, including the base of the tongue and tonsils (oropharynx), in both women and men.

3 vaccines are available :-
1.Gardasil (6,11,16,18)
2.Cervarix (16,18)
3.Gardasil 9

Is HPV vaccine only for girls?
No, it is for both boys and girls.

Age 11-26 years.
Then what is that 9-11 years or 11-12 years criteria?
Actually most of the vaccination programme for adolescent is in that age group. So to avoid that extra visit it has been scheduled so.
What about beyond 26 years?
It is not required because such cases are either already exposed or already infected.
In <14 years -2 doses is needed to mount same immunity.

Dose 2 or 3 .
-interval between the doses should be of 4 weeks.

Route intramuscular

Type capsid proteins.

Pregnancy is a contraindication. But if did vaccination then no need to abort.

For the doubts regarding vaccination, you should consult your physician.

-Upasana Y. :)

Wednesday, February 21, 2018

Thiamine and Beri-Beri: A Summary

  • Vitamin B1 is Thiamine.


(TCA = TriCarboxylic Acid cycle aka Kreb's cycle ; LDH = Lactate Dehydrogenase ; PDH = Pyruvate Dehydrogenase ; TPP = Thiamine PyroPhosphate)
  • Peripheral neuropathy in dry beri-beri is symmetric, sensorimotor, distal > proximal and non-inflammatory demyelinating type.
  • Wernicke's syndrome is reversible early while Korsakoff psychosis is reversible in only 20% cases.
  • Wernicke-Korsakoff syndrome has typical damage to dorsomedial nucleus of thalamus and mamillary bodies.
  • Clinical manifestations of B1 deficiency is worsened by glucose load! As seen in pathophysiology, excess of glucose with relative or absolute deficiency of B1 - as TPP - causes diversion from the preferred PDH pathway (linked to TCA), to the LDH pathway causing life-threatening lactic acidosis. Hence, in a patient with alcohol intoxication/ chronic alcoholism a B1+glucose cocktail is given as they usually are deficient in B1.
Biochemistry pearl: Other co-factors in PDH pathway alongside TPP are Lipoic acid, Coenzyme A, FAD(H) and NAD(H).

DIAGNOSIS:

Clinical diagnosis with confirmatory lab work - that includes:
  • Diagnostic - Blood or RBC transketolase activity and increase after intramuscular B1 administration
  • Supportive - Blood thiamine, pyruvate and lactate levels
MANAGEMENT:

You give what the patient lacks. An acceptable regimen is:

Injection B1 100 mg intramuscular for 1 week
followed by
Tablet B1 10 mg once-daily per-oral for 1 month.

Let me know if anything needs clarification. Happy studying!
--Ashish Singh.


Sunday, February 18, 2018

Cushing's Syndrome: A Quick Review

Definition: Clinical syndrome characterized by signs and symptoms of raised blood cortisol levels.

Etiologic classification:





  • Pituitary Cushing's is Cushing's disease.
  • ACTH dependence simply means if raised ACTH is the cause of raised cortisol.
  • Feedback loop, more correctly negative feedback loop, implies if cortisol level influences ACTH level inversely. Ectopic Cushing's is caused my malignant cells that continuously proliferate and hence, continuously make ACTH, regardless of cortisol levels.
  • Therapeutic administration of ACTH hormone for long periods can cause ACTH-dependent Cushing's. However, they are exceedingly rare (and hence, omitted from the whiteboard for simplicity).

(MCC= Most Common Cause ; B/L= Bilateral ; U/L=Unilateral)

Clinical Features:

CUSHINGOID

Central obesity, Cervical fat pads (with moon face and fish mouth = Cushingoid habitus), Collagen fiber weakness, Comedones (acne)
Ulcers (peptic)
Striae, Skin thinning & bruising
Hypertension, Hyperglycemia, Hirsutism
Immunosuppression, Infections
Necrosis (Avascular) of femoral head, Neuropsychiatric symptoms
Glucose intolerance, Growth retardation

Osteoporosis, Obesity
Impotence and menstrual abnormalities
Diabetes



Diagnosis:



High dose DXM or CRH don't bother ACTH or cortisol levels in Ectopic Cushing's as they're out of the feedback loop.

Other tests include:
  • 24 hour urinalysis
  • Midnight salivary cortisol
  • 9 am cortisol
  • Overnight low-dose DXM suppression test
  • B/L inferior petrosal sinus sampling
  • Electrolytes and routine CBC
(DXM=Dexamethasone)


Management:
  • Iatrogenic: Withdraw steroids slowly.
  • Pituitary: Trans-sphenoidal resection OR radical hypophysectomy, less commonly
  • Adrenal: Surgical resection with post-op prednisolone OR medically treat with Metyrapone or Aminoglutethimide.
  • Ectopic: Chemotherapy and Radiotherapy for small cell lung cancer OR surgical resection for carcinoids.


Let me know if anything needs clarification.
Happy studying!

-- Ashish Singh.

Schizophrenia First Rank Criteria : Mnemonic

Kurt Schneider laid down the First Rank Symptoms of Schizophrenia.
They're tedious to remember but we need to know them for MCQs and entrance tests!
So here goes :

Mnemonic :
ABDS VV (Very Vella)

A = Audible Thoughts (Echo de la Penses)
B = Broadcasting Thoughts + Insertion/Withdrawal of Thoughts
D = Delusional Perception
S = Somatic Passivity

V = Volition absent (Avolition)
V = Voices speaking / Arguing

That's all !

Few contributions to Schizophrenia :

The word was Coined by : Bleuler
Demence Praecoxe : Morel
Dementia Praecox : Kraeplin
1st rank symptoms : Schneider

Bleuler also gave the 4 A's of Schizophrenia !
They are Avolition, Autism , Ambivalence and flat affect.

Hope this was a good list for you !
Happy studying !
Stay awesome !

~ A.P. Burkholderia

The Oedipus Complex

The Oedipus Complex has been an ever popular Freudian concept.
Here's a summary of Psychosexual development as per Freud and the Oedipus Complex concept.
I insist you put up with this incestuous concept :p

So Freud was an extraordinary Psychoanalyst and gave the stages of 'Psycho Sexual Development'  in his book 'Interpretation of Dreams'.

There Are 4 stages of Psychosexual development in Freud's opinion that all of us pass through to reach the mature stage eventually.

The 4 stages are :

1. Oral
2. Anal
3. Phallic
Latent period
4. Genital

Remember -
Mnemonic : On A PG break.

If one fails to break through any of these stages , it is said he'd develop specific psychiatric illnesses.
It's important for a child to go through these stages without 'fixation' over any of those.

For example Oral stage fixation Makes you SAD
Schizophrenia
Anxiety
Dependent Personality disorder.

Anal Stage fixation makes you an 'Anal' person.
So you're likely to develop Obsessive Compulsive disorder or Obsessive Compulsive Personality (Ankanastic Personality)

Phallic Stage Fixation is "complex."
So in previous stages , it's been obvious what the object of gratification has been (Mouth and Anus respectively).
This one's slightly more "complex".

So as per Freudian theory , Boys would be sexually fixated on their Mothers, viewing their Fathers as a threat ;
This is called the 'Oedipus Complex'.
And also have Castration anxiety.

The theory says similarly Girls would be sexually fixated on their Fathers , viewing their mothers as a threat ;
This is called the 'Elektra Complex'.
And have Penis Envy.

The Oedipus Complex :
So this stems from the Greek story where Oedipus marries his own mother unkowningly , after he kills his father.

King Laius was the king of Greek city Thebes. He and his wife Jocasta bore a child : Oedipus.
The problem is some Seer prophesized that this child would kill him. And so he sent away his child, who was found and raised in another city by another King. Years later he returned to Thebes and quarreled with an old man and ended up killing him.
After a while he was told that the King had been killed , and that he could take charge of the town if he defeats the Sphinx. He did so, and won the hand of the King's wife Jacosta as well.
Years later he found out the King was actually his Father , and his Wife was his mother.
Here's where the 'Oedipus Complex' gets its name from.

Electra Complex
Stems from another Greek story.
Electra was the daughter of Agamemnon, whose wife killed him.
Electra then avenged her father's death by killing her mother.
(Talk about Daddy's lil girl ;;) )

Another complex is 'Pharoah Complex' where siblings are fixated sexually on each other.

Fixation in Phallic phase leads to Paraphilias and Hysteria.

Hope this wasn't overly disturbing !
Happy studying !
Stay awesome.
~ A.P. Burkholderia

Saturday, February 17, 2018

Kallman syndrome mnemonic

Kallman Syndrome (also known as Olfactogenital dysplasia/syndrome or anosmic idiopathic hypogonadotropic hypogonadism)

Let's​ get down with the mnemonics!

'Kallman' kinda rhymes with 'Tallman', right? Well, "man" for it's more common in boys and Tall these individuals are of normal or even increased height (Tall).

The other features are:

K - kinda looks like an X so it's X-linked
K also sounds like C for Colorblindness
A - anosmia
L - lip (cleft lip and cleft palate)
N - nerve deafness
A - ataxia (cerebellar ataxia)
M - midline defects (cleft palate, cleft lip)

Other important points are:
- The defect is in the KAL gene which codes for the protein anosmin.
- It can be due to autosomal dominant or recessive inheritance.

That's all!

Stay awesome 

This post is written by Nikhil as part of the MSGAI.

Medicowesome secret project: Organ donation poem

Friday, February 16, 2018

How to write ERAS CV for the USMLE match and FAQs about the application

Writing ERAS CV

The ERAS CV is a very important part of your application. After filtering applications, your CV is given points based on special activities (international volunteering, unique  skills, exceptional research) and if your CV points reach the threshold set by the program, you're invited for an interview (I was told this by a faculty in an interview!) 

Take. This. Seriously.

The ERAS CV is very different from the usual CV because you have to fill in a pre-made format. It's confusing. You don't know what to do. This post is based on what I know about what's preferred. There's no right or wrong.

I'm writing this post is a question and answer format so it's easier to refer to. 

These are just preferences - see if it suits you! I tried to give credit to the friends that gave these tips along the way. Most of them are American Medical Graduates (AMGs) and my input is IMG lol (International Medical Graduate). 

How to start:
List all your accomplishments. Then, ask your parents when you finish jotting down everything - You may forget your achievements but your parents will remember every random award you won. (Thanks MB for the tip!) 

PARAGRAPHS OR BULLETS?
Bullets. Easier to read when you are reading 100 applications on the other side of the table.

WRITING DESCRIPTIONS:

What type of wording should I use in the description section? 
Example one: "Worked as a volunteer, duties included..."
Example two: "I had the opportunity to work with Dr. Smith as a volunteer..."
IkaN tip: Both are equally good but prefer one as it is short and sweet! 

Here's what the Dean of an AMG emailed (thanks for sharing HM!): No need to use complete sentences with activities. Use active verbs like a resume. It is NOT wrong to use full sentences if you prefer that approach, but it not expected. Example: “Delivered lectures to first-year medical students on cardiac physiology.”

How long should my descriptions be? 
IkaN tip: Keep it short. Write tweet-sized descriptions.

HM's Dean on how much to write: Think about how important the activity is and how many of these applications your readers are reading. If you have a critical role you may want to write more. A mere participant should not belabor the point too much.

REASON FOR LEAVING:

What do I write for "Reason for leaving"?  
IkaN tip: Be elaborate. The reader should know in a glance why you left. I read an AMGs CV and he was very clear even with respect to non-medical jobs. He wrote, "I had to leave because of change in location or because of better opportunities but I was never fired from any of these jobs." or "I left the leadership role but I continued as a volunteer..." (Thanks for sharing this MS!)

The downside of not being specific is that curious faculty may call you to know your reasons. This is what my IMG friend was asked by the PD on a phone call: "Why did you leave your XYZ training after 3 months? Why did you leave the lab after working for a year? I see no publications out of it!"
She had definite reasons and she explained to them elegantly on the phone and was granted an interview. But had she been elaborate on the CV, she probably wouldn't have received the anxiety-provoking phone call! 

HM's Dean on how much to write: Okay to say “activity concluded” or “graduated” or “internship ended.”

IkaN used: End of bonded service, End of internship, End of rotation (Because I didn't know this before!)

DATES AND HOURS:
Because of the period and hours, you worked in is important!

If I am currently working and do not intend to stop working during the interview season, can I put the "to" date in the future, say March 20XX, depending on my hire agreement? Or do I leave it blank? (PS: "Present" option isn't available in the ERAS CV.) 

It's okay to use future dates.

Since residency starts in July, your Program Director (PD) would want to know how will you manage to work for them and working for the other work, side by side. Keep answers ready :) 

What if I work 3 hours every month for a volunteering organization? How do I put it in weeks on the ERAS CV?
PDs are aware of the inflexibility of the ERAS CV when it comes to editing certain parts. You can mention the minimum number of hours in the hours/week box. Then describe the hours and frequency of your work clearly in the description.

NAME OF ORGANIZATION: 
Usually, it is the name of the Hospital or Medical School you rotated in.

If there is no organization and you worked voluntarily to do something - can you put the organization "Self"?
Yes.

Self-doubt: Is it work experience? Or does it go into extracurriculars?
I was confused while mentioning the blog (Medicowesome) and the book I wrote. 

A fellow I know replied this:
I would include the website/book in the extracurriculars section (not sure if there is a section like that but whatever is closest to that) unless it was an organization that was being run with a formal job post. I was a part of a youth organization in medical school and had held several posts but included those in the extracurricular section because it is not formal work experience. You could ask some other people for advice on this as well but I think work experience is not the most accurate.

I was leaning towards extracurricular since I was not really working for an organization. Not sure if being an entrepreneur counts as work experience! Also, I think ERAS says that if you are paid for it, you put it in work. If not, it's a volunteer experience. Since I wasn't getting paid, I doubted putting it under work experience.

What did I do? I listened to my gut and put it under Work Experience. Best decision I made :)

Artwork – especially if the artwork is displayed at a gallery or show
Music – make special note of shows or places you have performed at
Many people make the mistake of putting significant artistic skills in the ‘Hobby’ section.  This does not give yourself enough credit if you have done legitimately IMPRESSIVE artistic accomplishments.  You have to realize that faculty members are glazed over by all the research projects from candidates.

Think about this, wouldn’t you rather talk to someone about their artwork than their summer research project on colon cancer screening?  Me too.  I’d rather hear about something unique and new.  So if you have done some significant artistic, musical, or talent PUT it in the WORK SECTION. 

Source: https://www.residencyinterviewquestions.com/2015/09/08/strengthen-electronic-residency-application-service-eras-application/

LOCATION: 

What if I worked from home for an organization based in the US? How do I put it in?
Use the location of the organization, however, while writing the description use the words, "I worked remotely for..."
I needed this advice while figuring out how to mention Editor of First Aid, the company is based in Kentucky, not India (from where I usually worked)

I hope this gives a good general idea. I will be updating more points soon! Lemme know your questions in the comments below or email medicowesome@gmail.com

FREQUENTLY ASKED QUESTIONS:

Where do we put electives in my ERAS CV?
Work experience.
Who is the supervisor for electives?
The attendings you rotated under. Limit to two or three names. If you had multiple attendings, choose your favorite two. You can write 4-6 names but it is too much to read.

Can you include non-medical volunteer experience in your ERAS CV?
Here are a few things I am confused about:
Organized a medical conference
Was an editor for the college magazine
Can you write non-medical accomplishments in medical school awards?
Won a prize in a poster making competition (art, not research poster)
TOEFL score?
Accomplishments before medical school?

YES. Add whatever makes you look good and like a well-rounded person. It will help you during your interviews. 

Which hobbies should be included?
Only list hobbies that show initiative, perseverance, or skill (ie. sports, cooking, language fluency)
Do not list hobbies that would show a Program Director that you may be distracted (ie. social media, fantasy football, trying out different bars, playing video games)
List hobbies with achievements first - Like if you like to dance write about dance courses, etc. (Thanks AS for the tip!)

What can you edit once the CV is submitted?
I called ECFMG and found out - "personal information" section can be edited throughout the application season.

Will the program see the "view print CV" or "view print application" version of the CV?
Both.

How is the CV sorted? 
The CV is sorted in chronological order (dates) with your most recent accomplishments first, so don't worry about what to enter first.

Do we leave AOA and GHHS blank "select" or choose "No chapter at my school"?
No chapter at my school if there is no chapter.

Are you Board Certified? What does this mean? Is this the same as ECFMG certification?
No, it is not the same as ECFMG certification. Board-certified means having taken an American board exam.

RESEARCH RELATED:

Can we write about any of the articles that are submitted for publication? But bot published yet?
Yes.

If you've done a research project but also presented it as a poster, do we include that in our research experience or only as a poster presentation?
You can include it in research experience and as a poster.

What about Oral / PowerPoint presentations?
You can include it somewhere - I gave a presentation during electives so I wrote it in the work experience section.

There's another section under publications for oral presentation - Can you put elective presentations in that?
No. I had read long ago that only grand rounds are worth mentioning. ("Presentations" refer to presentations that have been FORMALLY accepted or invited at regional or national academic meetings. Presentations that you do in the context of your education, for instance on rounds or in clerkship conferences, etc. are NOT academic presentations and should not be listed on your CV.)
 
Do you add conferences you attended in work experience?
I don't know, I did not mention it in my CV- feel free to answer them if you know for sure.

What counts as a book chapter? Do textbooks such as First Aid count?
Yes, as long as you played a major role in writing a book chapter.

I have done my residency in India already. Do I add that to previous experience or previous training or in medical education as there is an option of master's training?
Previous training.

How do I write about a project that I worked on in research experience that has not been published?

I worked on the XYZ project at ABC hospital.

Responsibilities included:
- Collecting data of inpatient post-op patients for 18 months.
- Doing a statistical analysis of the data.
- Doing the literature review.

Questions from Indian medical students:

What about the column on Membership in Honorary/Professional Societies - How much importance does it have in a CV?  Which kind of societies can we put in? Do we have to describe them?
Some students have put:
- Student member, Rotaract Club of Caduceus (20XX-20XY)
- Member of Maharashtra Medical Council, Mumbai (Sr. No.: MMC/XIII/0515253; Reg. No.: 2140M137)
Can we include volunteer organizations such as Rotaract? Isn't MMC a council, not a society?
No need to mention. My seniors advised me against it. 

Writing about INDIAN INTERNSHIP in your CV:

How should we write an internship in work experience? Month wise for every rotation or one year experience as a whole?
One year experience.
Why? Month wise will make the CV redundant and long. It may be too boring to read. The reader might not focus on your other accomplishments based on longevity.

Was your medical education being extended? There was an extension in the internship - it's okay to check "No" if it was for electives (you extended it for training). If you had other reasons, go for "Yes".

Who is the supervisor for the internship? The dean or the head of the PSM department?
Anything is fine - You may also leave it blank or say, "Multiple supervisors".

Can we put an internship as a post-graduate training experience instead of work experience?
No. It is not post-grad because you are required to do it for a med school degree.
The internship is equivalent to the Americans intern year (which is PG training for them). They are supervised when they rotate through various departments and get paid for it. (That's what we do as well!) - So, good question!!!

That's all!

*phew* that was a lot! 

I hope this gives a good general idea. I will be updating more points soon! Lemme know your questions in the comments below or email medicowesome@gmail.com

Hoping to match this year,
IkaN (Pray for me, pray for the match in March!)

Immunomodulators mnemonic

Hello Awesomites :)

Let's work out an interesting way of remembering a few Immunomodulators and Chemotherapeutic agents today!

These mnemonics were submitted to us by Mikey.

1. SIRolimus
    Is it nephrotoxic? Does it cause pancytopenia?
    - Kidney SIRvives. It causes panSIRtopenia

2. MycophenolATE side effects:
    - M: Marrow suppression
    - ATE: for GI effects: Nausea, cramping and abdominal pain

3. What do you use Azathioprine for?
    - *Auto*thioprine - *Auto*immune conditions, as well as Rheumatoid Arthritis, Crohn's disease and glomerulonephritis

4. What is the MOA of Basiliximab and what are it's side effects?
 Say: Basilik, THE Reptile in aisle 2
    - THE: Tremor, Hypertension, Edema
    - It is an IL- 2R monoclonal antibody

5. What is the MOA of Trastuzumab and what is it used for? it's side effect?
    - It is a therapeutic antiobody againts HER2/neu receptor
    HER Breasts and Stomach *trust*ed you!
    - Used for Breast and Gastric cancers
    But, it hurts Heart too!
    - Causes Cardiotoxicity.

- Compiled by Riya

That's it!
Have an awesome day, you guys!