Hello :)
-Upasana Y. :)
PPRF = Paramedian pontine reticular formation
MLF = Medial longitudinal fasciculus
-Upasana Y. :)
Tuesday, August 15, 2017
Third nerve palsy
Hello :)
Before starting with the III nerve, Let us understand the term.
According to TABER'S medical dictionary, We need to understand 3 main type of palsy here.
1.NUCLEAR palsy :- Paralysis caused by lesion of the nuclei in CNS.
2.OCULAR palsy :- Paralysis of extraocular nd intraocular muscles.
3.MUSCULAR palsy :- Loss of the capacity of muscle to contract. It may be due to structural or functional disorders
-in the muscle at the myoneural junction,
-in efferent nerve fibres,
-in the cell bodies of nuclei of origin of the brain or of the gray matter of the spinal cord,
-in conducting pathways of the brain or spinal cord,
-in motor centres of the brain.
Third cranial nerve supplies
1. EXTRAOCULAR MUSCLES
-Superior rectus
-Inferior oblique
-Medial rectus
-Inferior rectus
2.INTRAOCULAR MUSCLES
-Levator palpebral superioris
-Ciliary body
-Iris sphincter msucle
THE LOCALIZATION OF THIRD NERVE LESION
-Supranuclear
-Nuclear
-Fascicular
-Basilar
-Intra-Cavernous sinus
-Superior orbital fissure
-Intra Orbital part
CLINICAL FEATURES OF THIRD NERVE PALSY:-
1. Ptosis - paralysis of LPS muscle.
2. Deviation – out, down and intorted (unopposed action of LR and SO).
3. Ocular movements:
• Adduction – MR
• Elevation – SR and IO
• Depression – IR
• Extorsion – IR and IO
4. Pupil is fixed and dilated – paralysis of sphincter pupillae muscle.
5. Accommodation is completely lost – paralysis of ciliary muscle.
6. Crossed diplopia – paralytic divergent squint.
7. Head posture – If the pupillary area is uncovered, head takes a posture consistent with the directions of actions of the paralysed muscles, i.e., head is turned on the opposite side, tilted towards the same side and chin is slightly raised. (Pathways between vestibular nuclei and oculomotor nuclei. These are Intranuclear pathway.)
FEATURES AND CAUSES OF THIRD NERVE LESIONS AT VARIOUS LEVELS
1. Supranuclear lesions
• Lesions of the cerebral cortex and supranuclear pathway produce conjugate paresis which affect both eyes equally.
• In supranuclear lesions although position and movements of the eyes are abnormal, they maintain their relative co-ordination and produce no diplopia.
2. Nuclear lesions
• Lesions involving purely the third nerve nucleus are relatively uncommon.
• Common causes include ; vascular diseases, demyelination, primary tumors and metastasis
• Lesions involving entire nucleus cause
-an ipsilateral third nerve palsy with ipsilateral sparing and
-contralateral weakness of elevation.
• Lesions involving paired medial rectus subnuclei (ventromedial nucleus) cause a wall-eyed bilateral internuclear ophthalmoplegia ( WEBINO ) characterised by defective convergence and adduction.
Before starting with the III nerve, Let us understand the term.
According to TABER'S medical dictionary, We need to understand 3 main type of palsy here.
1.NUCLEAR palsy :- Paralysis caused by lesion of the nuclei in CNS.
2.OCULAR palsy :- Paralysis of extraocular nd intraocular muscles.
3.MUSCULAR palsy :- Loss of the capacity of muscle to contract. It may be due to structural or functional disorders
-in the muscle at the myoneural junction,
-in efferent nerve fibres,
-in the cell bodies of nuclei of origin of the brain or of the gray matter of the spinal cord,
-in conducting pathways of the brain or spinal cord,
-in motor centres of the brain.
Third cranial nerve supplies
1. EXTRAOCULAR MUSCLES
-Superior rectus
-Inferior oblique
-Medial rectus
-Inferior rectus
2.INTRAOCULAR MUSCLES
-Levator palpebral superioris
-Ciliary body
-Iris sphincter msucle
THE LOCALIZATION OF THIRD NERVE LESION
-Supranuclear
-Nuclear
-Fascicular
-Basilar
-Intra-Cavernous sinus
-Superior orbital fissure
-Intra Orbital part
CLINICAL FEATURES OF THIRD NERVE PALSY:-
1. Ptosis - paralysis of LPS muscle.
2. Deviation – out, down and intorted (unopposed action of LR and SO).
3. Ocular movements:
• Adduction – MR
• Elevation – SR and IO
• Depression – IR
• Extorsion – IR and IO
4. Pupil is fixed and dilated – paralysis of sphincter pupillae muscle.
5. Accommodation is completely lost – paralysis of ciliary muscle.
6. Crossed diplopia – paralytic divergent squint.
7. Head posture – If the pupillary area is uncovered, head takes a posture consistent with the directions of actions of the paralysed muscles, i.e., head is turned on the opposite side, tilted towards the same side and chin is slightly raised. (Pathways between vestibular nuclei and oculomotor nuclei. These are Intranuclear pathway.)
FEATURES AND CAUSES OF THIRD NERVE LESIONS AT VARIOUS LEVELS
1. Supranuclear lesions
• Lesions of the cerebral cortex and supranuclear pathway produce conjugate paresis which affect both eyes equally.
• In supranuclear lesions although position and movements of the eyes are abnormal, they maintain their relative co-ordination and produce no diplopia.
2. Nuclear lesions
• Lesions involving purely the third nerve nucleus are relatively uncommon.
• Common causes include ; vascular diseases, demyelination, primary tumors and metastasis
• Lesions involving entire nucleus cause
-an ipsilateral third nerve palsy with ipsilateral sparing and
-contralateral weakness of elevation.
• Lesions involving paired medial rectus subnuclei (ventromedial nucleus) cause a wall-eyed bilateral internuclear ophthalmoplegia ( WEBINO ) characterised by defective convergence and adduction.
3. Fascicular lesions
• Causes are similar to nuclear lesions.
-Benedikt syndrome involves the fasciculus as it passes through the red nucleus and is characterised by ipsilateral 3rd nerve palsy and contralateral extrapyramidal signs such as hemitremor.
-Weber syndrome involves the fasciculus as it passes through the cerebral peduncle and is characterised by ipsilateral 3rd nerve palsy and contralateral hemiparesis.
-Nothangel syndrome involves the fasciculus and the superior cerebellar peduncle and is characterised by ipsilateral 3rd nerve palsy and cerebellar ataxia.
-Claude syndrome is a combination of Benedikt and Nothangel syndromes.
4. Lesions involving basilar part of the nerve
• As the nerve runs in the subarachnoid space at the base of skull unaccompanied by any other cranial nerve, isolated third nerve palsies are frequently basilar.
• Causes :
1. Aneurysms at the posterior communicating artery cause isolated third nerve palsy with involvement of pupil.
2. Extradural hematomas which may cause tentorial pressure cone with downward herniation of the temporal lobe. This compresses the third nerve as it passes over the tentorial edge. Initially there occurs fixed, dilated pupil, which is followed by a total third nerve palsy.
3. Diabetes causes isolated 3rd nerve palsy with sparing of the pupillary reflexes.
5. Lesions involving intracavernous part of the nerve
• Because of its close proximity to other cranial nerves, intracavernous 3rd nerve palsies are usually associated with involvement of the 4th and 6th nerves, and the 1st division of trigeminal nerve.
-PULSATILE EXOPHTHALMOS can also be seen.
-PULSATILE EXOPHTHALMOS can also be seen.
• In intracavernous 3rd nerve palsy, pupil is spared. Sometimes, pupil may be constricted owing to inv of sympathetics.
• Causes :
• Causes :
1. Diabetes may cause vascular palsy.
2. Pituitary apoplexy – may cause a third nerve palsy as a result of hemorrhagic infarction of a pituitary adenoma (after child birth), with lateral extension into cavernous sinus.
3. Intracavernous lesions – aneurysms, meningiomas, carotid-cavernous fistulae and Tolosa-Hunt syndrome (granulomatous inflammation).
6. Lesions of the intraorbital part of the nerve
• May cause isolated extraocular muscle palsies or may involve either superior division or inferior division or both.
• Causes : orbital tumors, pseudotumors, trauma and vascular diseases.
7. Lesions of pupillomotor fibres
• B/w the brainstem and the cavernous sinus, pupillomotor fibres are located superficially in the superior median quadrant of the nerve.
• They derive the blood supply from the pial blood vessels whereas the main trunk of the 3rd nerve is supplied by vasa nervorum.
I want to thank my teacher for such a beautiful explanation.
I hope it helped.
Do read about the following . (though I will write on this topic also)
1.Injury of Paramedian pontine reticular formation
2. Ptosis in Horner's syndrome and oculomotor nerve palsy.
-Upasana Y. :)I want to thank my teacher for such a beautiful explanation.
I hope it helped.
Do read about the following . (though I will write on this topic also)
1.Injury of Paramedian pontine reticular formation
2. Ptosis in Horner's syndrome and oculomotor nerve palsy.
Drugs that can cause TOXIC MYOPATHIES
Hello :)
1. TYPE- Inflammatory
-Cimetidine
-D- Penicillamine
-Procainamide
-L-tryptophan
-Levodopa
2.TYPE- Non-Inflammatory necrotizing or vacuolar
-Alcohol
-Cholestrol lowering agents
-Chloroquine
-Colchicine
-Cyclosporine and tacrolimus
-Emetine
-Isoretinoic acid
-Vincristine
-Labetalol
3.TYPE -Rhabdomyolysis and myoglobinuria
-Alcohol
-Amphetamine
-Cocaine
-Heroin
-Phencyclidine
-Meperidine
4.TYPE -myosin loss
-Non depolarizing neuromuscular blocking agent
-steroid
That's all.
-Upasana Y. :)
1. TYPE- Inflammatory
-Cimetidine
-D- Penicillamine
-Procainamide
-L-tryptophan
-Levodopa
2.TYPE- Non-Inflammatory necrotizing or vacuolar
-Alcohol
-Cholestrol lowering agents
-Chloroquine
-Colchicine
-Cyclosporine and tacrolimus
-Emetine
-Isoretinoic acid
-Vincristine
-Labetalol
3.TYPE -Rhabdomyolysis and myoglobinuria
-Alcohol
-Amphetamine
-Cocaine
-Heroin
-Phencyclidine
-Meperidine
4.TYPE -myosin loss
-Non depolarizing neuromuscular blocking agent
-steroid
That's all.
-Upasana Y. :)
Monday, August 14, 2017
ABC vs CAB for CPR
Hello :)
If someone ask the medical personnel, What is ABC ?
Unfailingly, the answer will be A-airway, B-breathing ,C-Circulation.
But now this has been changed to C-A-B.(I didn't know this)
C-Compression /circulation
A-airway
B-breathing
(SOURCE :- I took the following content from https://medictests.com/abc-vs-cab-correct/ )
In 2010 the AHA made a radical change to how we approach CPR. Up until then we all lived by the trusty "ABC" (Airway, Breathing, Circulation) method of resuscitation. Not surprisingly, though, the AHA's ongoing research began to show that compressions are the most important part of CPR and any delay or interruption resulted in worse outcomes. It was also discovered that during CPR, the patient's blood stays oxygenated for 4-6 minutes after their last breath. In response to this research, and in an attempt to simplify CPR for untrained laypeople, the AHA decided to switch our initial approach from ABC to CAB. While this change is medically sound, it has cause a lot of confusion for healthcare professionals who regularly use ABC for other scenarios. So, ABC vs CAB, which is correct?
With indisputable evidence that compressions are the most important part of CPR, it is no wonder that AHA has been dee-mphasizing airway and breathing. In fact, in ACLS, the AHA has gone as far as to suggest that endotracheal intubation may not be as important as we once thought. While it remains the ultimate airway, the AHA suggests BVM or supraglottic airway ventilations because they reduce the interruption of compressions.
In accordance with this paradigm shift, the AHA has changed ABC to CAB in the event of cardiac arrest. Unfortunately, though, some healthcare providers have incorrectly interpreted this change in cardiac arrest to be a change that applies to every other medical call. Some are under the impression that the AHA is the governing body over prehospital and emergency care, which is simply not the case. CAB is no doubt a revolution in cardiac arrest care but it is not meant to change the way we approach our "normal" patients.
Here is a short list of examples of when ABC vs CAB should be used
ABC
Overdose
Trauma
Altered mental status
Diabetic emergencies
Respiratory failure
Airway obstruction
Respiratory Distress
CAB
Cardiac Arrest
Conclusion:-
It does not have to be one or the other! While ABC has been phased out by the AHA, it still is the de facto initial assessment used in every non-cardiac arrest call. CAB, on the other hand, is now being used during cardiac arrest to remind practitioners and laypeople of the importance of compressions. In general, it is not useful to confine yourself to one ideology "because they say so." It is much more productive to understand each approach and use critical thinking to choose the best route for your patient.
That's all
-Upasana Y. :)
If someone ask the medical personnel, What is ABC ?
Unfailingly, the answer will be A-airway, B-breathing ,C-Circulation.
But now this has been changed to C-A-B.(I didn't know this)
C-Compression /circulation
A-airway
B-breathing
(SOURCE :- I took the following content from https://medictests.com/abc-vs-cab-correct/ )
In 2010 the AHA made a radical change to how we approach CPR. Up until then we all lived by the trusty "ABC" (Airway, Breathing, Circulation) method of resuscitation. Not surprisingly, though, the AHA's ongoing research began to show that compressions are the most important part of CPR and any delay or interruption resulted in worse outcomes. It was also discovered that during CPR, the patient's blood stays oxygenated for 4-6 minutes after their last breath. In response to this research, and in an attempt to simplify CPR for untrained laypeople, the AHA decided to switch our initial approach from ABC to CAB. While this change is medically sound, it has cause a lot of confusion for healthcare professionals who regularly use ABC for other scenarios. So, ABC vs CAB, which is correct?
With indisputable evidence that compressions are the most important part of CPR, it is no wonder that AHA has been dee-mphasizing airway and breathing. In fact, in ACLS, the AHA has gone as far as to suggest that endotracheal intubation may not be as important as we once thought. While it remains the ultimate airway, the AHA suggests BVM or supraglottic airway ventilations because they reduce the interruption of compressions.
In accordance with this paradigm shift, the AHA has changed ABC to CAB in the event of cardiac arrest. Unfortunately, though, some healthcare providers have incorrectly interpreted this change in cardiac arrest to be a change that applies to every other medical call. Some are under the impression that the AHA is the governing body over prehospital and emergency care, which is simply not the case. CAB is no doubt a revolution in cardiac arrest care but it is not meant to change the way we approach our "normal" patients.
Here is a short list of examples of when ABC vs CAB should be used
ABC
Overdose
Trauma
Altered mental status
Diabetic emergencies
Respiratory failure
Airway obstruction
Respiratory Distress
CAB
Cardiac Arrest
Conclusion:-
It does not have to be one or the other! While ABC has been phased out by the AHA, it still is the de facto initial assessment used in every non-cardiac arrest call. CAB, on the other hand, is now being used during cardiac arrest to remind practitioners and laypeople of the importance of compressions. In general, it is not useful to confine yourself to one ideology "because they say so." It is much more productive to understand each approach and use critical thinking to choose the best route for your patient.
That's all
-Upasana Y. :)
Saucerization and Arthrodesis
Hello :)
I was fascinated with this two terms :- Saucerization in Osteomyelitis and Arthrodesis (I studied it in treatment of foot drop).
SAUCERIZATION
-Extension of surgical debridement
-Debrided wounds left open widely through excision of overhanging soft tissue and bone
-Wounds drain freely (otherwise If we close it the pus will keep on collecting)
-Abscesses do not form
-Limited to areas where it causes acceptable loss of function e.g. Tibia and femur
Arthrodesis
The term arthrodesis refers to surgical fusion of a joint.
The indications for this are pain & instability in a joint and, in some situations, following the failure of joint replacement.
FIXATION POSITIONS
The optimum positions for arthrodesis in different joints are as follows:
1. SHOULDER:
-In such a position that the hand can comfortably reach the mouth.
-The person will be able to perform the day-to-day activity like eating.combing,scratching the back,cleaning.
-Arthrodesis of shoulder joint is usually reserved for a flail joint as may follow a brachial plexus injury.
-Stabilization of this joint may lead to improvement in the remaining distal function of the arm.
2. ELBOW: 90° of flexion.
(Suppose you won't be able to flex it 90 degree ,then what will happen? Try eating food with that position. You won't be able to do that without this.)
3. WRIST: A few degree of extension
4. THUMB:
-MCP joint in 20° of flexion.
-IP joint in slight flexion.
5.FINGERS:
MCP joints in 20° -30° of flexion.
(These joints are rarely fused).
Proximal IP joints in 40° -45° of flexion (less in middle & index fingers)
-Upasana Y. :)
I was fascinated with this two terms :- Saucerization in Osteomyelitis and Arthrodesis (I studied it in treatment of foot drop).
SAUCERIZATION
-Extension of surgical debridement
-Debrided wounds left open widely through excision of overhanging soft tissue and bone
-Wounds drain freely (otherwise If we close it the pus will keep on collecting)
-Abscesses do not form
-Limited to areas where it causes acceptable loss of function e.g. Tibia and femur
Arthrodesis
The term arthrodesis refers to surgical fusion of a joint.
The indications for this are pain & instability in a joint and, in some situations, following the failure of joint replacement.
FIXATION POSITIONS
The optimum positions for arthrodesis in different joints are as follows:
1. SHOULDER:
-In such a position that the hand can comfortably reach the mouth.
-The person will be able to perform the day-to-day activity like eating.combing,scratching the back,cleaning.
-Arthrodesis of shoulder joint is usually reserved for a flail joint as may follow a brachial plexus injury.
-Stabilization of this joint may lead to improvement in the remaining distal function of the arm.
2. ELBOW: 90° of flexion.
(Suppose you won't be able to flex it 90 degree ,then what will happen? Try eating food with that position. You won't be able to do that without this.)
3. WRIST: A few degree of extension
4. THUMB:
-MCP joint in 20° of flexion.
-IP joint in slight flexion.
5.FINGERS:
MCP joints in 20° -30° of flexion.
(These joints are rarely fused).
Proximal IP joints in 40° -45° of flexion (less in middle & index fingers)
To show the importance of fixation
Casts (Colle's Cast)
Hello :)
These days, I am attending orthopaedics posting. And I am loving it.
I saw casting. Following questions were asked to me during the procedure.
Q. Define Casts and Slabs.
A. Cast & slab are methods of a temporary immobilization for a wide variety of musculoskeletal conditions not only for disorders of bones but also for many other disorders related with tendons, muscles and soft tissues
Cast: are circumferential immobilizers which is surrounding the whole circumference of the limb
Slab: are non-circumferential immobilizers which is only support apart of the circumference of the limb.
Q. Define Traction and Splints.
A. TRACTION -Traction is a method of restoring alignment to a fracture through gradual neutralisation of muscular forces. Traction is applied to the limb distal to the fracture, so as to exert a continuous pull in the long axis of the bone.
SPLINT - A device used for support or immobilization of a limb or the spine. Any material used to support a fracture is known as splint.
Q. What is Colle's Fracture?
A. It is not just fracture lower end of radius but a fracture dislocation of the inferior radioulnar joint.
Q. Do you know anything regarding Colles Cast.
A. It is a type of Immobilization method. It is the Below elbow cast (10 – 20 degree palmar flexion, 15 – 20 degree ulnar deviation) .
So, Colle`s cast :- It is a below elbow cast in supination.
Ideally it has to meet the following 4 criteria :
-Firm fit at the dorsum
-Firm fit at the volar fracture apex
-Just snuggly fitting at the forearm
-Metacarpophalangeal joints should be free to move.
These days, I am attending orthopaedics posting. And I am loving it.
I saw casting. Following questions were asked to me during the procedure.
Q. Define Casts and Slabs.
A. Cast & slab are methods of a temporary immobilization for a wide variety of musculoskeletal conditions not only for disorders of bones but also for many other disorders related with tendons, muscles and soft tissues
Cast: are circumferential immobilizers which is surrounding the whole circumference of the limb
Slab: are non-circumferential immobilizers which is only support apart of the circumference of the limb.
Q. Define Traction and Splints.
A. TRACTION -Traction is a method of restoring alignment to a fracture through gradual neutralisation of muscular forces. Traction is applied to the limb distal to the fracture, so as to exert a continuous pull in the long axis of the bone.
SPLINT - A device used for support or immobilization of a limb or the spine. Any material used to support a fracture is known as splint.
Q. What is Colle's Fracture?
A. It is not just fracture lower end of radius but a fracture dislocation of the inferior radioulnar joint.
Q. Do you know anything regarding Colles Cast.
A. It is a type of Immobilization method. It is the Below elbow cast (10 – 20 degree palmar flexion, 15 – 20 degree ulnar deviation) .
So, Colle`s cast :- It is a below elbow cast in supination.
Ideally it has to meet the following 4 criteria :
-Firm fit at the dorsum
-Firm fit at the volar fracture apex
-Just snuggly fitting at the forearm
-Metacarpophalangeal joints should be free to move.
That's all for today.
-Upasana Y. :)
Arsenic Poisoning
Hello awesomites!
Here's a Mnemonic on Arsenic Poisoning
The mnemonic is AR4SENIC
A-Aldrich Mees line (Nail)
R-Raindrop pigmentation
Reinsch Test (Gutzeit test used nowadays)
Rashes(fading measles rashes)
Red velvety mucosa(Postmortem finding)
S-Subendocardial hemorrhage(Postmortem finding)
E-Excess pigmentation and keratosis (Palms and soles)
N-Neuritis
I-Iron oxide n BAL(antidote)
C-Cholera like symptoms
I hope that it's helpful.
That's all!
Thank you.
Diagnostic criteria of neurofibromatosis type 1 mnemonic
The criteria are met in an individual if two or more of the features listed are present.
The mnemonic is "FANCOOL"
F: Family history
A: Axillary freckles (known as CROWE'S SIGN)
N: Neurofibromas (2 or more)
C: Café-au-lait macules (6 or more)
O: Optic gliomas
O: Osseous (sphenoid dysplasia)
L: Lisch nodules in the eyes.
Thanks for reading.
Madhuri
Sunday, August 13, 2017
Diagnostic features in the X-ray and probable pathology in the Sinus
Hello :)
1. Haziness of sinuses only :- Sinusitis
2. Bony expansion without erosion :- Benign tumefaction e.g Polyposis
3. Decreased air shadow in nasal cavity without bony expansion :- Hypertrophic rhinitis
4. Bony erosion with expansion :- Malignancy
5. Bony defect without expansion of haziness :- Surgically induced (Iatrogenic) or fracture
6. Fluid level in maxillary sinus :- Sinusitis with pus signifying acute bacterial maxillary sinusitis
This question was asked to me by my friend and it was fun to find the answer.
(Source :-Otolaryngology at the eleventh hour By Anupam Mishra)
That's all for today.
-Upasana Y. :)
1. Haziness of sinuses only :- Sinusitis
2. Bony expansion without erosion :- Benign tumefaction e.g Polyposis
3. Decreased air shadow in nasal cavity without bony expansion :- Hypertrophic rhinitis
4. Bony erosion with expansion :- Malignancy
5. Bony defect without expansion of haziness :- Surgically induced (Iatrogenic) or fracture
6. Fluid level in maxillary sinus :- Sinusitis with pus signifying acute bacterial maxillary sinusitis
This question was asked to me by my friend and it was fun to find the answer.
(Source :-Otolaryngology at the eleventh hour By Anupam Mishra)
That's all for today.
-Upasana Y. :)
Saturday, August 12, 2017
New treatment regimen for Hepatitis C
Hey guys! I have copied this article from the FDA website more or less. You will definitely find it helpful.
The U.S. Food and Drug Administration today approved Mavyret (glecaprevir and pibrentasvir) to treat adults with chronic hepatitis C virus (HCV) genotypes 1-6 without cirrhosis (liver disease) or with mild cirrhosis, including patients with moderate to severe kidney disease and those who are on dialysis. Mavyret is also approved for adult patients with HCV genotype 1 infection who have been previously treated with a regimen either containing an NS5A inhibitor or an NS3/4A protease inhibitor but not both.
Mavyret is the first treatment of eight weeks duration approved for all HCV genotypes 1-6 in adult patients without cirrhosis who have not been previously treated. Standard treatment length was previously 12 weeks or more.
“This approval provides a shorter treatment duration for many patients, and also a treatment option for certain patients with genotype 1 infection, the most common HCV genotype in the United States, who were not successfully treated with other direct-acting antiviral treatments in the past,” said Edward Cox, M.D., director of the Office of Antimicrobial Products in the FDA’s Center for Drug Evaluation and Research.
There are at least six distinct HCV genotypes, or strains, which are genetically distinct groups of the virus. Knowing the strain of the virus can help inform treatment recommendations.
The safety and efficacy of Mavyret were evaluated during clinical trials enrolling approximately 2,300 adults with genotype 1, 2, 3, 4, 5 or 6 HCV infection without cirrhosis or with mild cirrhosis. Results of the trials demonstrated that 92-100 percent of patients who received Mavyret for eight, 12 or 16 weeks duration had no virus detected in the blood 12 weeks after finishing treatment, suggesting that patients’ infection had been cured.
Treatment duration with Mavyret differs depending on treatment history, viral genotype, and cirrhosis status.
The most common adverse reactions in patients taking Mavyret were headache, fatigue and nausea.
Mavyret is not recommended in patients with moderate cirrhosis and contraindicated in patients with severe cirrhosis. It is also contraindicated in patients taking the drugs atazanavir and rifampin.
That's all!
-VM
Thursday, August 10, 2017
Factors increasing iron absorption in the intestine mnemonic
Hello! Long time, no see!
Did you know a number of dietary factors influence iron absorption?
Ascorbate (vitamin C) and citrate increase iron uptake in part by acting as weak chelators to help solubilize it in the duodenum.
Did you know a number of dietary factors influence iron absorption?
Ascorbate (vitamin C) and citrate increase iron uptake in part by acting as weak chelators to help solubilize it in the duodenum.
Cushing Ulcers : An overview
Hi Everyone ! Here's a short post on Cushing and Curling ulcers.
For Cushing Ulcers you need to remember these key points :
C
U - Ulcerating - can even perforate.
S - Stomach
H - Head injury induced Stress Ulcer
I - lNcreased
N - INcreased
G - Gastric Acid secretion.
Stress ulcers are typically non ulcerative superficial erosions of the gastric mucosa.
They occur when a person is subjected to physical stress in the form of Trauma, Sepsis, Burns, Hemorrhage among many others.
Psychological stress doesn't cause 'Stress ulcers' , although it does pre dispose to getting Peptic Ulcer Disease on its own accord. All the same, it doesn't cause 'Stress ulcer'.
Cushing ulcers are type of stress ulcers occuring secondary to Head injury. They occur in the stomach commonly , and are associated with increased Gastric acid secretion. They are typically erosive and ulcerative , more likely to perforate than other stress ulcers.
Another named stress ulcer is Curling Ulcer occuring secondary to Burns. They occur in the 1st part of duodenum commonly , and are NOT associated with increased Gastric acid secretion.
Presentation :
Painless upper GI bleeding within 1-2 days of traumatic event.
Usually slow and intermittent bleeding.
Diagnosis :
Endoscopy.
(More to rule out other causes of GI bleed rather than ruling this in).
Treatment :
- Treat underlying causes.
- Fluids
- Gastric pH to be maintained > 5 (using PPI like Pantoprazole)
- If lot of bleeding - Ligation of vessel at base of ulcer.
That's all!
Happy studying !
Stay awesome !
~ A.P.Burkholderia
Subscribe to:
Posts (Atom)