Selinexor

Selinexor (Selective inhibitor of nuclear export) inhibits XPO1 (exporter protein 1).

XPO1 is often overexpressed in tumors leading to transport of tumor suppressor proteins like p16, p14, p27 from nucleus to cytoplasm and there by evading the apoptosis.

Luspatercept

Here is a submission by Kirtan on Luspatercept!

Luspatercept (recombinant fusion protein containing Activin receptor type IIB moeity) blocks excessive SMAD2/3 activity (Mothers against decapentaplegic homolog) lying downstream of TGF-beta signalling by binding endogenous TGF-beta family members, including Bone morphogenetic proteins (BMP), Activin, Inhibin, Lefty A/B, Artemin, Persephin, GDF, GDNF and MIS.

Acute type-II respiratory failure causes mnemonic

Hi!

Causes of Acute type-II Respiratory failure mnemonic:
DEPRESSION

Radiologic features seen in pulmonary emphysema mnemonic

Hi!

Radiologic features seen in a case of pulmonary emphysema (Chest X-ray PA view):

mnemonic: PSTR-ANTR

Clinical features of Pneumococcal Pneumonia mnemonic

Hi!

Clinical features of pneumococcal pneumonia mnemonic:

HI STREPTOCOCCUS

Risk factors for pneumococcal pneumonia mnemonic

Hi!

Risk factors for pneumococcal pneumonia mnemonic:

PNEUMONIA

Ventricular demand pacing

Hey!

I came across a patient with VVIR pacing today. I was wondering why we didn't do DDD instead. Let's learn what it is and why (In short!)

Five position code for pacemakers

Hello!

For those who don't know about pacemakers:

Mnemonic to remember colors in Doppler echocardiography

Short post :)

The mnemonic is BART:

Causes of primary hypothyroidism mnemonic

Hi!

Common causes of primary hypothyroidism:
( mnemonic: DR. HIT )

Fact of the day - BUC in UGI bleed

Hi!

Blood urea levels are positively associated with upper GI bleed. But here's the fact:

Causes of elevated serum amylase mnemonic

Hi!

Causes of elevated serum amylase mnemonic:

RAISED-AM

Causes of Acute Pancreatitis mnemonic

Hi!

Causes of Acute Pancreatitis mnemonic :

ABCDEFGHIjK