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Greetings people!
Tissue plasminogen activator is an enzyme that catalyzes the conversion of plasminogen to plasmin, the enzyme responsible for clot breakdown.
It is used in the treatment of embolic or thrombotic stroke.
Contraindicated in hemorrhagic stroke and head trauma. The antidote for tPA in case of toxicity is epsilon aminocaproic acid.
Mnemonic is, "TPA"
T - Thrombotic and embolic stroke (Use)
P - Plasmin (Mechanism of action)
A - Aminocaproic acid (Antidote)
The dose mnemonic is, "TPA" again!
T for ten:
10% of dose given as bolus.
P mirrored looks like a 9:
0.9 mg/kg dose, maximum 90 mg.
A for an hour:
Rest of the dose is given as an infusion lasting for 60 minutes.
That's all!
-IkaN
Hello!
This is practical exam related concept.
In a patient with neurological symptoms, you'd like to know whether the person is left handed or right handed. Why?
Dominant hand is important in medicine because it helps us figure out the dominant hemisphere - especially, in patients with stroke.
People who are right handed have their left cerebral hemisphere dominant. 70% left handed people are left hemisphere dominant.
To figure out handedness, you can ask the person with which hand he writes. If illiterate - You can ask with which hand he prefers to eat, combs hair, etc.
Threading a needle is an excellent way to determine handedness because very frequently people tend to hold the thread in the dominant hand and hold the needle with the non dominant hand.
That's all!
I'm left cerebral hemisphere dominant. You?
-IkaN