Fas- fas ligand interactions and uveitis

-Fas ligand/ FasL/ CD95 ligand is a type 2 membrane protein belonging to the TNF superfamily and is found on lymphocytes.

-In the eye, it is expressed on Iris and corneal endothelial cells.

-In the rest of the body, it is expressed on the thymus, testes, and the brain.

-Liver and intestines express this only in periods of severe inflammatory process.

- Apoptosis of the T lymphocytes can be triggered by FasL. Loss of this mechanism is touted to be one of the causes of uveitis.

Mechanism by which it acts is believed to be the selective apoptosis of cells producing TNF or by IL2 activation of lymphocytes.

-Sushrut

Effector blockade in the eye.

This is a mechanism by which the eye wards off the secondary effector phase of the immune response arc.
Thus, the cell mediated immunity appears to function less effectively in the uvea compared to the rest of the body.
Possible mechanisms include-

1. Immunomodulatory cytokines produced by the ocular tissues.

2. Immunomodulatory neuropeptides produced by ocular nerves

3. Functionally unique APCs.

4. Compliment inhibitors

..and some other factors.

-Sushrut

Choroid and fungi

The large spaces of choroid act as a sort of trap to organisms, especially fungi. Therefore most fungal lessons of the posterior segment begin as choroiditis.

AASLD guidelines for treatment of chronic hepatitis B in pregnancy

Hello!

Here is a quick summary.

Relative risk of invasive breast carcinoma based on histological examination

Hello Awesomites!

I was going through some questions on Breast cancer. Found this piece of information.

Based on histological examination of benign breast tissue, we can assess the relative risk of invasive breast carcinoma.

Why do we want to assess this? In some studies it has been found that histologic features, the age at biopsy, and the degree of family history are major determinants of the risk of breast cancer after the diagnosis of benign breast disease. 

1. Findings suggestive of No increased risk
-Adenosis (sclerosing or fibroid)
-Cystic (macro & /micro)
-Duct ectasia
-Fibrosis
-Fibroadenoma
-hyperplasia
-Mastitis
-Squamous metaplasia
-Periductal Mastitis

2. Findings suggestive of slightly increased risk (1.5 to 2 times)
-Hyperplasia, moderate or florid, solid or papillary
-papilloma with fibrovascular core

3. Finding suggestive of moderately increased risk (5 times)
-Atypical hyperplasia, ductal or lobular

4. Insufficient data to assign a risk
-solitary papilloma of lactiferous sinus
-Radical scar Lesion

Happy Studying!
Upasana Y. :)

Chronic thromboembolic pulmonary hypertension (CTEPH)

Hello everyone,

We will be talking about CTEPH today.

Calot's triangle vs Cholecystohepatic triangle

Hello Awesomites!

I would like to highlight difference between these two terms. It is confusing.

1.Cholecystohepatic triangle:

Medial boundary- Common hepatic duct
Inferior boundary- Cystic duct
Superior boundary- Inferior edge of liver

2. Calot's triangle:

Medial boundary- Common hepatic duct
Inferior boundary- Cystic duct
Superior boundary- Cystic artery

Happy Studying!
Upasana Y. :)

Efferent optic nerve fibres

It's interesting to note that the optic nerve, which is considered to be a purely sensory nerve has some efferent fibres, that is, fibres from the brain to the optic disc. The presumed role of these fibres is in dreams, where the brain sends impulses to the retina, image is generated and it is carried back to the brain via the afferent fibres.

-Sushrut

CEAP classification of Chronic venous insufficiency

Hello Awesomites!

The classification and staging of chronic venous insufficiency (clinical severity) can be measured by a scoring system called clinical manifestations, etiological factors, anatomical distribution, and pathophysiological conditions.

Happy Studying!
Upasana Y. :)

Anterior chamber associated immune deviation

Some specific antigens when placed in the anterior chamber of the eye result in a suppression of cell mediated immunity, with a normal humoral component.

There is something known as the ' oculo splenic axis' , whereby the antigens travel via the trabecular meshwork and reach the spleen. In the spleen, they secrete MIP 2 which attracts the NK cells. The NK cells in turn secrete IL10 and TGF beta. The T cells in this environment become regulatory cells and suppress the cell mediated immunity. Production of IL2 is suppressed.

The eye is an immuno privileged organ, as it needs to be structurally maintained pristine to preserve it's light carrying capability. ACAID is a mechanism by which Nature attempts to limit unwanted inflammatory responses in the anterior chamber.

It has implications in intraocular tumors, autoimmune, and infectious immune responses.

-Sushrut

PS- The failure of ACAID in the mechanism of lens induced uveitis still remains unexplained!

ACCF/AHA versus ESC guidelines: Pharmacologic therapies for management of HFrEF

Hello everyone!

This video is based on the ACC/AHA guidelines from 2013 in addition to ACC/AHA 2017 update vs ESC guidelines from 2016. I recommend watching at 2x speed because I talk too slow :P

 

What it takes to be a compassionate physician

Hello everyone!

I participated in the Daniels Family Foundation Scholarship in honor of an honorable physician at my program.  The requirement to participate was to submit a brief (500 words or less) essay that describes how you have demonstrated what it takes to be a compassionate physician dedicated to the practice of general internal medicine.

If possible, I want you to write an essay too. Please email them to me (medicowesome@gmail.com). I would love to hear your experiences (and maybe even publish them on Medicowesome if you'd like)

Let me go first and share my essay with you:

Authors diary: Are you ready for solo practice?

"Are you ready for solo practice?"

My father read out the topic from a WhatsApp forward he had received.

I was drinking tea, with all the absent-mindedness of a resident who barely has the luxury to sit down and have said cup of tea.

I stared at my father aghast, wondering where this daunting question sprung from, till he elaborated that it was the topic of an essay competition.

As I read through the message myself I corrected him, "That’s not what it says! It's asking whether you're adequately trained for solo practice in the future."

"Your future is just a couple of years away. Will you be ready by then?" he asked.

"I don’t know about ready, but I’m sure I’ll be adequately trained," I answered.

He nodded and after a beat, leaned in and asked,
"But have you really thought about it yet?" ((And what makes you so sure? Have you really thought about it yet?))

That got me thinking indeed.

As a year old paediatrician, the most important lesson I learnt was how much there was to learn. My days were spent working with any time off work spent catching up on missed sleep. I felt like I whizzed through my first year, barely retaining any of the knowledge I was expected to glean as an intern. Being a houseman had felt like operating at spinal level, for the lack of there being a synaptic level
any lower than that. Perhaps I wasn't ready at all.

My face seemed to betray my thoughts as my father interrupted them. "Instead of lamenting over what you haven’t learnt," he asked kindly, as if reading my thoughts, "Why don’t you try and think about how much you have?"

Convinced that I had learnt nothing of value anyway, I decided to humour him nevertheless. I spoke about  my housemanship month by month, about what each sick child and each hopeful parent had taught me. A resident doctor in a busy municipal hospital barely gets time for their own basic life needs like food, sleep, or even a bath (and needless to say, sleep always takes priority!). Most of what we learn is on the go. Nobody gets enough time to go back and read about the cases we've seen in the ward. Thankfully the vast number of cases and immense workload ensures that we at least know how to manage basic ailments that a child presents with.
However amidst putting orders, histories, and ensuring investigations for so many patients, we forget to learn about the little things - how to allay a parent's concerns about their child, how important the so called 'cosmetic' part of our practice is. Of course, all these concerns are still things that can be worked on if one can put their heart into it.
And yet, are we being adequately trained to do this for future solo practice? The answer, shockingly, is a resounding no.

Add to this, we're barely trained to make decisions by ourselves, especially when there are so many seniors waiting to teach us, guide us, and by extension, take responsibility for our actions. How is one supposed to adjust to suddenly being so independent?

In a tertiary care setting, we are used to sending out references left, right, and centre. We fail to learn the basics of anything that would result in us putting even one toe out of our own speciality and instead rely on the services of others, who are just a single written call away. It's very obvious that this is not going to be the case when one starts practising by oneself.

Another important thing that nobody teaches you in residency is how to ask for remuneration for our services. Being employees of the state or the corporation, we are used to working endlessly for a fixed salary being ddeposited in our accounts each month. As a result, we fail to realise our worth in monetary terms, there being a certain amount of guilt with each patient we charge. Maybe this is something we realise only after getting into private practice, where taking care of every patient is translated into putting food on our own plate. At this stage in life, while I hope I wouldn't underestimate and thus undercharge for my abilities, I really don't know what that would be like be like.

So, coming back to the question that started it all - no, I am not adequately trained for future solo practice. And no, I am not ready for it either. But two years down the line, I have hope for the former statement. And as for the latter? Well, I believe that at least that "I'm not ready." will transform into" I'm not ready...yet. But I'm willing to stick around till the day I am."

Written by Aditi

ACEI and ARBs in congestive heart failure

Hey everyone!

Today, I will be talking about ACEI and ARBs in congestive heart failure (based on ACC and ECS guidelines).

Here are a few points on what the guidelines say:

EPISODE 04 - INTERNSHIP DIARIES (What will I do with your blood? -Vials and sampling)

- By Upasana and Jay

It has been a tired day at the hospital. You are almost at the end of your day of duty when your senior resident asks you,

“Dr Kesh, can you please prepare the Laboratory forms, sign them for me and then, submit these blood samples to the Main laboratory?

“Yes sir!” You pressure a smile and look at the blood samples and the empty Laboratory request forms needing your signature and your gleaming new stamp with your licence number.

You sit down to prepare the blood samples.

EPISODE 03 - INTERNSHIP DIARIES (Let me gain access into your veins)

(Lesson 1.2)

Inserting an IV line or an Intravenous line is a very much of an expected skill from a Medical professional. Although often performed by Nurses, the skill can come handy at any time because in a case of a hard insertion the nurse or the ancillary staff may refer the patient to you to perform.

Before inserting an IV line you need to know what is an IV Cannula or an IV Catheter.

A cannula or a catheter is a small tube made out of medical grade materials that would allow a medical professional introduce or extract a substrate to or from the body. In a case of an INTRA-VENOUS cannula the access is taken in to the VEINS.

Usually an IV cannula can be used to introduce IV fluids, IV medications as well as sometimes to draw blood(often at the insertion moment).

1. The catheter itself is composed of (a) a tip for insertion into the vein, (b) wings for manual handling and securing the catheter with adhesives, (c) a valve to allow injection of drugs with a syringe also called a LUER lock-valve, (d) an end which allows connection to an intravenous infusion line, and capping in between uses.
2. The needle (partially retracted) which serves only as a guidewire for inserting the cannula.
3. The protection cap which is removed before use.

(By courtesy of Wikipedia (https://en.wikipedia.org/wiki/Peripheral_venous_catheter) retrieved 7/5/2019)

These cannulas come in different shapes and sizes, and the sizes are measured in BIRMINGHAM GAUGE SYSTEM often abbreviated as G. In this system the lower number is having a higher diameter and a higher number is having a lower diameter of the catheter tube. (This is different from French Gauge System where it is opposite from this numbering system and is often used in NGT tube sizes)

So, an 18G IV cannula is larger than a 20G IV cannula.

The recognizing of these cannulas are done by the colour of its Luer lock-valve or the tip of the needle in some varieties.

The colours are pretty constant throughout the world but sometimes it differs. So always refer to your senior before checking out a cannula for the first time or better yet, READ WELL of its packaging.

(Note that in some countries 26G could be of Purple colour)
- Table by courtesy of Wikipedia (Retrieved 7/5/2019) -

Check for your needed equipment and material.

• Alcohol or Hand Sanitizer/Soap and water
• An alcohol wipe. - To sanitize the skin
• A tourniquet. - To block the venous flow and engorge the vein as well as fix it.
• An IV cannula - As mentioned above.
• A suitable plaster or a Tegaderm® - To fixate the IV cannula/catheter on to the skin
• A syringe with normal saline - To flush the Catheter
• A clinical waste bin with a sharp disposal section - To dispose the waste including the needle.

STEPS

1. Identify a visible and/or tangible vein. Try to feel it. A rule of thumb is, the better you feel the vein the more successful your insertion will be.
2. Once you identify the vein, apply the tourniquet and recheck on the vein if its engorged and tangible.
3. Apply alcohol on your hands and clean it. Wear your gloves properly as explained before; in case you were already wearing gloves, check if you can request for a change of your gloves. Touching a patient without gloves is discouraged.
4. Clean the patient's skin with Alcohol wipe, a cotton ball soaked in Isopropyl Alcohol 70% or Ethyl Alcohol 70% is alright.
5. Before inserting the catheter and check if the catheter tip is clear without any manufacturer's defects such as a defect end. Check the needle for its bevel up. 
6. Stretch the skin distally, and look for your insertion point. If your vein-in-concern is not much engorged you can try slightly tap on it.
7. Tell your patient to expect a sharp pinch on their point of insertion.
8. Insert your needle beveled up, usually around 30-45 degrees to the skin and advance your needle to see if there is a flashback of blood at the hub of the syringe.
9. If you see the flashback, then advance the whole needle about 2-3mm and then retrieve the needle slowly and check if a streak of blood is following the returning needle. If it does...Congratulations! IF NOT, try withdrawing the needle a bit and change the position until you see the flashback.
10. If you cannot do it while the needle is inside, then retrieve the whole catheter and re insert at a different point of a different vein.
11. If you still cannot, then ask for help from a senior.
12. In the fortunate incident of you are already inside the vein, remove the tourniquet and while removing the needle, give pressure to the top of the cannula tip already inside the body so the blood will not reek out making your field a mess!
13. Insert your prepared flush into the catheter and try to inject. If it proceeds with no resistance, then you are good to go!
14. Get your Primed IV line or HEPLOCK (which is used to administer IV medications in a later  time via the catheter and it will stop the blood from reeking out) or close the end with the white cap of the needle(Often used with those catheter types with Luer lock-valve where a heplock is not needed)
15. Take your previously prepared Plasters or already opened Tegaderm® and secure the IV catheter on to the skin. There are several methods of securing the IV catheter on to skin using plasters. We will discuss 
16. Dispose your needle to the sharps disposal.
17. Clean and wash your hands.

Congratulations, you are done with your IV catheter/cannula insertion.

*******

You look at the face of the patient after finishing your work, and you are proud that you got access in one hit and did not spill the blood.

"Thank you doctor!" Your patient thanks you.

"You are welcome!" You smile and leave the patient with your tray.


*************

Thanks guys for the support! Thanks for the messages you have been sending to my Whatsapp requesting for more articles. We will try to provide more topics soon. 

With love,

Jay

Fregoli and Capgras.

So this post is regarding Delusional misidentifiaction syndromes.
There are two of them i. e. Capgras and Fregoli syndrome.

Now both of them are super confusing and are often asked in entrances. I made a mnemonic to remember them. If you can remember any one of them, you can figure out other.

So I hope all of you are aware of GOT-Game of thrones! Remember Arya stark had face swaping ability? She killed entire Frey family by it. So did how she kill them? She disguised herself as head of the family - Walder Frey and killed them.

So take A from Capgras. Here A stands for Arya stark. Arya killed family of Frey by disguising as Walder Frey (Family member). So in Capgras, patient thinks that murderer is going to disguise as a  family member and kill him. Eg Nurse disguised as a wife to kill him.
Capgras is also know as The Delusion of doubles! 

OR (To non GOT fans)

FreGoli:
F= Family
G=Gun (In hindi you can simply remember Goli)
"Family members trying to kill patient with Gun but disguised as someone else"
Eg: Wife disguised as Nurse to kill patient (Husband)

"Valar Morghulis"

That's it

-Demotional bloke.

EPISODE 02 - INTERNSHIP DIARIES (Protecting you and myself)

NOTICE!

Awesomites, I'm super sorry for being super late, I was so busy with my MD graduation hence I couldn't update the promised topics on Internship Diaries. I will update as soon as possible all the topics we need to discuss.

With love,

Jay

(LESSON 1.1)

WEARING SURGICAL GLOVES

       There are three forms of wearing gloves. 

1. OPEN, 
2. CLOSED 
3. ASSISTED. 

Closed is the most sterile method and used mainly in operating rooms where you wear gowns and glove yourself and asepsis is highly expected. 

You utilize the Open method in situations in wards, and other Non-OR situations. 

Assisted method is when someone else such as, a nurse or a fellow colleague will serve you the gloves and you simply slip your hands in.

OPEN method,

1. Remove whatever you are wearing in your hands, including rings, bracelets and watches. Try to keep it free elbow-down.
2. Wash your hands with soap, and use Sterilium(R) or Isopropyl or Ethyl alcohol 70%. (Using them will eliminate the remaining bubbles of the soap.) 
3. Then wipe your hands with a sterile towel.
4. You will take your surgical gloves, open the outer cover and bring the inner cover outside without touching inside the gloves. 

   

   Surgical Gloves Inner cover

5. Leave it on a flat clean surface and open the flaps, and you will see two gloves one for the right hand and the other for left hand.
6. You will also notice the sleeves of the gloves are rolled upwards. The inside out part is considered unsterile and the inside the roll part is considered sterile. 

   

   S = Sterile part   |    US = Unsterile part

7. So you use your non sterile dominant hand, hold the glove from the non sterile outside part and slip over your non dominant hand. Do NOT flap back the sleeve because will get contaminated because you are not yet wearing gloves on that hand.
8. Now use your non dominant hand with the glove on, and slip the four long fingers of your hand into the rolled sleeve of the other glove. Because it is sterile. Bring it up and slip the glove over your non gloved hand. And flip back your sleeve.
9. Then use your newly gloved hand to roll down the sleeve of your other glove from the inside the roll.

You are successfully gloved!!!

In closed method someone will open the outer cover for you and you take the inner cover out, and wear it in such a way where you do not touch the glove at all skin-to-skin directly, but it will be discussed later. Too much info in one post will cause brain freeze. 

In Assisted method after gowning yourself, someone else will open gloves and serve you. Check if the thumb side is correct accordingly and slip in. If not you will be stuck and will need a new pair of gloves. Waste of time, waste of gloves and waste of effort!!

*******
You put on your gloves and see the nurse has prepared alcoholized cotton balls, 5 plaster strips of around 4 inches long and partially opened the IV catheter pack.

You take one alcoholized cotton ball and start looking for a vein.

[ To be continued... ]

*******

The answers to our previous questions regarding gloving are,

1. There are 3 methods
       1. Open
       2. Closed
       3. Assisted

2. There are 2 types of gloves
       1. Examination gloves - Often clean but not essentially sterile although some sterile varieties exist.
       2. Surgical gloves - Often sterile and comes in a tightly sealed pack. Do not use if the pack is already open.

Of Surgery and Wounds

Hey guys, here’s a classification of surgical procedures, wounds and their infection risk.

[Please click on the image to enhance it]

Thank you for your time.
- Ashish Singh.

What Is Going On In Fibromyalgia?

Hi there! Let’s talk about pathophysiology of fibromyalgia; a chronic disorder where fatigue and widespread pain feature prominently.

Current hypothesis says, it’s caused by aberrant peripheral and central pain processing.
Two key features are allodynia, that is, pain in response to a non-painful stimulus and hyperaesthesia, which is, exaggerated perception of pain in response to mildly painful stimulus.

Modern research says, certain antidepressants- with both serotonergic and noradrenergic activity- such as TCAs and venlafaxine, can relieve pain and other symptoms; suggesting the pathway involvement.

Some evidence says, alternative therapies such as acupuncture and spa therapies alleviate pain, which have been postulated to act via similar spinal pain-modulatory pathways.

CSF studies show increased levels of substance P, with decreased levels of noradrenaline and serotonin metabolites. All three are neurotransmitters involved in descending pain-modulatory pathways in the spinal cord.

PET images show an abnormal central dopamine response to pain.

The critical question here is: what is cause and what is effect?

Small sample size and short periods of study, remain the most cumbersome challenge to our complete understanding of fibromyalgia.  



Thank you for reading.
- Ashish Singh.

Mnemonic: Duke’s Criteria for Infective Endocarditis

Infective endocarditis is diagnosed using the modified Duke’s criteria.
Let’s look at them in an easy-to-remember way.

MAJOR CRITERIA
It’s, quite literally, proving the name Infective Endocarditis to be true.

Infective, that is, positive blood culture:
• Typical bugs in 2 separate cultures
• Persistently positive blood cultures, say > 12h apart
• Single positive blood culture for Coxiella burnetii

Endocarditis, that is, endocardium involvement:
• On imaging with 2D Echo or CT, look for vegetation, abscess, pseudoaneurysm or dehiscence of prosthetic valve
• On clinical exam, find new regurgitation murmur

MINOR CRITERIA
Remember, patients feel very ill when they have infective endocarditis.
Predisposing factors: congenital heart disease, prosthetic heart valves, iv drug abuse
Fever > 38 °C
Vascular phenomena: emboli, Janeway’s lesions
Immunologic phenomena: glomerulonephritis, Osler’s nodes

What if the blood culture is positive but does not meet the major criteria?
It’s considered as a minor criterion (casually speaking, problematic but not majorly problematic).

How do we use this for diagnosing?
2 major OR
1 major + 3 minor OR
All 5 minor criteria, make up the diagnosis.

Clinical Pearl: Fever with any new-onset murmur is taken as infective endocarditis, unless proven otherwise.



Hope this helps. Happy studying!
- Ashish Singh.

CABG For Undergraduates

CABG is Coronary Artery Bypass Graft; a surgical procedure where dying heart muscle is resupplied with blood.

Indications
[decided after a SYNTAX scoring system]
• Left main stem disease
• Triple-vessel disease involving proximal left anterior descending
• Patients unsuitable for angioplasty 
• Failed angioplasty
• Refractory angina

Procedure
• The heart is usually stopped and blood pumped artificially by a machine outside the body, a cardiac bypass. An alternative, that does not require this, is minimally invasive thoracotomy.
• As the graft, patient’s own great saphenous vein, internal mammary artery or radial artery is used. Multiple grafts may be placed. Arterial grafts last longer but may cause donor site numbness.

After CABG
• Continue aspirin 75 mg/day indefinitely. Consider clopidogrel, if aspirin contraindicated.
• Ensure optimal management of hypertension, diabetes and dyslipidemia.
• Counsel for smoking and alcohol cessation.
• Chart out graded physical activity through rehabilitation.
• Uncommonly, angina may persist or recur [from poor graft run-off, distal disease, new atheroma or graft occlusion]. If so, restart anti-anginal drugs and consider angioplasty.

Clinical Pearl: Recent randomised control trials indicate that early procedural mortality rates and 5-year survival rates are similar after PCI and CABG.



Thank you for reading.
- Ashish Singh.

Understanding Refeeding Syndrome

Refeeding syndrome is a life-threatening metabolic complication of - stay with me - refeeding. It can happen via any route after prolonged starvation.

Who are at risk?

They’re patients with prolonged artifical feeding [parenteral or enteral], malignancy, anorexia and alcoholism.

Why does it happen?

During starvation, the body uses fat and protein for energy. There’s no carbs so there’s little to no insulin.

After refeeding, carbohydrate load causes a spike in insulin level.

Now first prof biochemistry tells you, more insulin means more cellular uptake of phosphate.

That’s it. That low serum phosphate level is the main problem.

How does it present?

Non-specifically and catastrophically. Features are rhabdomyolysis, red and white blood cell dysfunction, respiratory insufficiency, cardiac arrhythmias and seizures.

Left unchecked, it can lead to sudden death.

How do I prevent it?

Identify at-risk patients and give high-dose, high-potency Vitamin C and B complex injection, during re-feeding window.

Monitor vitals and labs closely. Close involvement of nutritionist is ideal.

What if it’s already happened? How do I treat it?

The biggest challenge is management of complications.

As regards phosphate, get the levels back up. Administer oral as well as parenteral phosphate, upto 18 mmol per day.

Thank you, that’d be all.

- Ashish Singh.

What are APS?

APS or Autoimmune Polyendocrine Syndromes are exactly what the name suggests.
They’re autoimmune in origin and they attack more than one endocrine system.

[Please click on the image to enhance it]

Let’s not forget autoimmunity begets autoimmunity.

APS are commonly seen with hypogonadism, vitiligo, alopecia, pernicious anaemia and coeliac disease, among others.

That’d be all. Happy studying!

- Ashish Singh.

PR depression in pericarditis

Do you know what P-R segment deviations in acute pericarditis mean?

It is due to subepicardial atrial injury!

Residency in India: Harassment, abuse and suicide

A few days ago, a resident committed suicide. One of us committed suicide.

In my opinion, it seems like the reason for the suicide was harassment, abuse, and excessive work load. If you ask any resident in any government hospital in Mumbai - they are all treated the same. The verbal abuse is probably different - They used casteist slurs for her. If you are privileged, they will call you different names.

How can we make sure this never happens again? Stop carrying forward the culture of abuse. It is high time. We have to fight the system. The past. The belief that it is okay just because it's residency. Don't look at how our seniors treated us but look at how we treat our juniors.

We need to treat each other better. Treat others how you would like to be treated yourself.

We need to help each other.

It is our fault that the life of an innocent was lost. It's because we didn't fight and we stayed silent when we saw abuse around us. We need to create awareness among medical students that will be joining residency. Let's talk about the abuse and how we can stop it. Residents should know who to report to without fear of negative consequences.

It will take time and it will probably not change in a day. But we are the future and we need to fight.

Fundoscopic images of Diabetic Retinopathy

Fundoscopic images of Diabetic Retinopathy

Images and audio by Sushrut.

Indications of skin grafting mnemonic + notes

Hello,

Indications of skin grafting :

☆ Mnemonic - BITS

Sites of Bronchiectasis

Bronchiectasis site in lung depends upon the etiological factors

Upper lobe bronchiectasis:

Mnemonic: Upper - PCT
Upper- Upper lobe
P- Post radiation
C- Cystic fibrosis
T- Tuberculosis

Middle lobe bronchiectasis:

Mnemonic: MMC (Like BMC!)
M- Middle lobe
M- Mycobacterium avium
C- Ciliary dyskinesia

Lower lobe bronchiectasis:

Mnemonic: Left-ICA (Internal carotid artery)
Left- Lower lobe
I- Interstitial lung disease
CA- Chronic aspiration

That's all.
Thank you :)

-Demotional bloke

History, physiology and medical aspects of fasting

Hello everyone,

My senior resident at JFK Medical Center did a presentation on fasting. I thought of sharing it with you (especially since it is Ramazan/Ramadan).

Hook effect of prolactin in large pituitary adenomas

Hello everyone,

Here's something I learnt today when a case of large pituitary adenoma causing visual field loss was presented today.

But let's talk about my favorite subject first - Immunology!

The intensity of an antigen-antibody interaction depends primarily on the relative proportion of the antigen and the antibody. A relative excess of either will impair adequate immune complex formation. This is called the “high-dose hook effect” or the “prozone phenomenon.”

This is important consideration whe measuring prolactin. Extremely high levels of prolactin can interfere with the assay and produce falsely low readings.

This high-dose hook effect occurs because there is not enough antibody to bind to both ends of all antigenic peptides, in this case, prolactin.

Most prolactin is complexed to a single antibody. Only few remaining prolactin peptides are “sandwiched” and therefore detectable.

This results in a falsely low prolactin value.

Hence, as the antigen concentrations increase, there is a proportional increase in assay titers up to a certain level. Antigen concentrations above this threshold level would “hook” down the assay values resulting in very low measurements.

In order to avoid the high-dose hook effect, the serum prolactin should be estimated in appropriate dilution in all patients with large pituitary tumors.

-IkaN (tired Internal Medicine Resident)

Source:
The 'hook effect' on serum prolactin estimation in a patient with macroprolactinoma. https://www.ncbi.nlm.nih.gov/m/pubmed/11303248/

Protein gap

The gamma gap aka paraprotein gap or protein gap is the difference between total serum proteins and albumin measured from a comprehensive metabolic panel.

Albumin accounts for the majority of total serum protein.

Viral infections, plasma cell malignancies, or autoimmune conditions there is an excess of immunoglobulins, raising the total amount of serum protein independent of albumin.

The gamma gap is typically considered to be elevated if it is above 4 g/dL.

In the right clinical context, gamma gap should be worked up with SPEP, UPEP, and a serum free light chain assay.

Random exercise: Calculate the protein gap.
Total protein 8.9 g/dL (normal 6.4-8.3 g/dL)
Albumin is 3.6 g/dL (normal 3.4-4.8 g/dL)

That's all!

-IkaN

Work up of thyroid nodule

Hello,

Here is the shorter version of this post: Investigating thyroid nodule for Step 2 CK (link: https://www.medicowesome.com/2016/06/step-2-ck-investigating-thyroid-nodule.html)

So - if you find a thyroid nodule on physical examination - what do you do next?

Caudal anaesthesia

Hello Awesomites!

Caudal anesthesia is a type of epidural anesthesia. 

INDICATIONS
The indications for single shot CA are abdominal,urologic or orthopedic surgical procedures located in the sub-umbilical abdominal, pelvic and genital areas, or the lower limbs, where postoperative pain does not require prolonged strong analgesia. Examples include inguinal or umbilical herniorrhaphy, orchidopexy, hypospadias and club foot surgery.

Anatomical landmarks (Figure)
The sacrum is roughly the shape of an equilateral triangle,with its base identified by feeling the two
posterosuperior iliac processes and a caudal summit corresponding to the sacral hiatus.The sacral hiatus is located at the caudal end of the median crest and is created by failure of the S5 laminae
to fuse (Figure). The hiatus is surrounded by the sacral cornu.

Preparation
Obtain consent for the procedure either from the patient or, if appropriate, from the parents. After induction of general anaesthesia and airway control, the patient is positioned laterally (or ventrally),
with their hips flexed to 90°. Skin disinfection should be performed carefully, because of the proximity to the anus.
After defining the bony landmarks of the sacral triangle, the two sacral cornuae are identified by moving your fingertips from side to side.The gluteal cleft is not a reliable mark of the midline. The puncture is performed between the two sacral cornuae. The needle is oriented 60° in relation to back plane, 90° to skin surface. The needle bevel is oriented ventrally, or parallel to the fibers of the sacro-coccygeal ligament.
After verifying absence of spontaneous reflux of blood or cerebrospinal fluid (more sensitive than an aspiration test), injection of LA should be possible be without resistance. Inject slowly (over about one minute).

-Upasana Y. :) 

HbA1c and Estimated Average Glucose

Hello Awesomites!

Sounds new. Wait till the end!

Do You know what is HBA1c?

HbA1c is produced by the condensation of Glucose with N-terminal valine of each beta chain of HbA.

Diagnostic importance
The rate of synthesis of HBA1c is proportional to exposure of RBC to glucose. Concentration of HBA1c is indication of blood glucose concentration.
It reflect mean blood Glucose level over 2-3 months prior to its measurement.If HbA1c is <7% then diabetes is in good control. To get an accurate result the concentration should be monitored for several months.

Estimated average glucose (eAG) :- It is new term in diabetic management.It helps to interpret HbA1c levels into average glucose concentration.
eAG(mg/dl) =(28.7×HbA1c) - 46.7

Drawback
The A1c doesn’t replace self blood-glucose monitoring. Because the A1c is an average of all your blood sugars, it does not tell you your blood sugar patterns. If someone has certain type of hemoglobin mutations (variation in the hemoglobin structure) (HbA1c is falsely low) , is severely anemic (low red blood cell count), iron deficient( HbA1c is falsely high) or is being treated blood transfusions or medications to increase the production of new red blood cells, the A1c test may not be accurate.

Thank you.
Upasana Y. :)

Diabetic Retinopathy

Here is Upasanas video on Diabetic Retinopathy.

I edited the slides so you can see better :)

Slides are available for download here:

PARTNER 3 trial journal club

Hey everyone!

A few months ago, I did a journal club on the PARTNER 3 trial.

I have been meaning to create an audio file and upload the whole journal club as a video on YouTube but unfortunately, I don't seem to have the time.

This is why, I decided to go ahead and release my slides instead so it helps anyone who is doing a journal club on the same :)

Oblique muscle mnemonic

It can be hard to remember which oblique does what. Remember this. 'Extortion' as we all know is forcing money out of someone. People from the 'inferior' strata of the society extort money. See where am I  going?!

So! Inferior oblique causes extorsion( 'extortion' is a bit different- c'mon, be a grammar Nazi!)
What remains? Superior oblique. So..it then is responsible for intorsion.

Similar is the case for superior and inferior recti.

Hope I saved you from ophthalm extorting your precious time.

-Sushrut

Cardiovascular changes in pregnancy

At term
- Blood volume increases by 50%
- increased uterine blood flow 500-800ml/min
- uterus recieves 10-15% cardiac output

Philosophy of Medicowesome

Internship dairies: Finding a vein

So here's a quick post in support of Internship Diaries. I would like to give you advice on how to do blood draws and insert IV lines.

First of all, learn properly before you try it on another human being. Watch YouTube videos, learn by observing.

Second, the tourniquet is your friend. If you don't have a tourniquet, use a glove instead. It will make the veins more plump.

Third. Feel the vein before you attempt to insert the needle or cannula. FEEL IT.

Be patient and take your time. It's better to spend 30 seconds extra than to poke somebody and spend five minutes more trying to find a vein.

I know that this is phlebotomy and nursing advice and it may not be needed in hospitals where the ancillary staff does it.

But hey, hope this helps! :)

PS: I just realized I've written a longer post before here: https://www.medicowesome.com/2015/10/tips-on-how-to-find-vein-or-phlebotomy.html

-IkaN

Strabismus/Squint

Hello Everyone!

                 Strabismus has been confusing me for long, so I decided to come up with a chart:

You can download the chart at https://drive.google.com/file/d/1leP_Ir3FZU0J-0isZcYHkgd5x_ujQFX8/view?usp=sharing

Thanks!

Chaitanya Inge
Upasana Yadav

Propofol infusion syndrome

Hello friends!

It is the triad of metabolic acidosis, skeletal myopathy and acute cardiomyopathy.

It is seen in children on prolonged infusion.

It occurs due to failure of metabolism of free fatty acids.

Madhuri.

Propofol

Hi friends!

Propofol is a non-barbiturate intravenous anesthetic agent.
Colour : milky white liquid.
Chemical name : 2,6-diisopropylphenol.
Composition: soyabean oil, glycerol and lecithin.
Metabolism:70% in liver, 30% in lungs and kidneys.

Propofol is associated with quick recovery. So it is the drug of choice for day care surgeries.

Systemic effects:
CVS : It decreases systemic vascular resistance leading to fall in blood pressure causing tachycardia. But it actually causes bradycardia. The reason being blunting of carotid body receptor response (which we have studied in our physiology)
RS : It causes maximum depression of upper airway reflexes. So it is the drug of choice for insertion of laryngeal mask airway.
CNS :  It causes cerebral vasoconstriction leading to fall in intracranial pressure. It is an antiemetic, antipruritic and antioxidant.
It is an anticonvulsant but may cause involuntary movements.

Thanks for reading!
Madhuri.

Massive blood transfusion strategy

In patients with massive haemorhage with a loss of more than 40% of blood volume - rapid transfusions are given with colloids, crystalloids and packed RBCs.

This causes coagulopathy by diluting the a clotting factors.

Hence, prophylactic infusion of platelets and fresh frozen plasma is done.

Initially, it was given in a ratio of 1:1:4
One part platelet & ffp transfusion to every 4 bags of blood.

It has been renewed now to 1:1:1 ratio

It has caused significant reduction in mortality 40% versus 60%

Thank you!

40% blood loss translates to grade 4 hemorrhagic shock or grade 1 degree of urgency per the urgency grid for obstetric hemorrhage. I removed the grading in the initial part of the post to avoid confusion as different grades mean different severity of shock based on the scale used.

- sakkan

EPISODE 01 INTERNSHIP DIARIES - (The best way to FINISH is to START first!)

PROLOGUE

                   It’s a busy day, and to top with that you are running late. It’s your first day as a Medical Intern and you are super excited for your future 1 year.

You are entering into this huge sophisticated hospital with the shining silver name plate attached to it “SAN JOSE GENERAL HOSPITAL” and you reach the smiling and pleasant looking receptionist with round glasses on.

“Hello Good morning, I am Kesh, a new medical intern here. Where should I go?”

“One minute please!” She tells you and starts checking something on her computer.

“Hello Dr. Kesh” She looks back at you.

“Omg!” You think. “This is it! People are calling me doctor now! Yoohoo!” you smile widely.

“Please proceed to the Department of Internal Medicine, please look for Dr Wen, your mentor!”

You thank her and follow her guide.

****

Dr. Wen is a helpful young doctor in his late thirties who happens to be the Chief Resident of Internal Medicine. His orientation on the hospital rules were quite lengthy but was important. His ending was quite remarkable.

“Being a doctor is a dream of many but achieved by few. You are among the lucky few. You are supposed to lead a health care team. which means you should know all the necessary medications and side effects and how it would affect the human being! Your whole team relies on you. There for you need to be responsible and accountable to yourself, your team and your patient.” Dr Wen said. “ You have spent years in Medical school already, and now it's time for the training here and I wish that all of you would take the best chance of that objective by learning to how to be a good healer.” he continued.

“Please proceed to your respective wards now. If you have any problem during your internship, please ask for my help. I will definitely help you!” said he at last.

You check the slip in your hand.

“Ward 3” it says. You slowly walk toward your post.

***

“Dr. Kesh” You hear your nurse is shouting your name

“Yes?”

“Could you please insert an IV line to this new admission?” She asks.

“Here are your gloves, your aseptic instruments and IV catheter. Thanks you so much!”

The nurse leaves you with a full tray and a newly admitted patient who looks worried.

“Can I please insert you an IV line for your vein so that we can hook you up to IVF?” You seek consent!

“Yes sure” Patient gives permission.

You take the pack of Surgical gloves into your hands.

"Now what to do?" you think!

[To be continued...]

********

Pre lesson questions

1. What are the gloving techniques you know?

2. What are the types of gloves you know?

3. What unit is used to measure the IV cannula size?

4. What are the most common areas of IV cannula insertion?

5. What is a heplock?

Expect the next episode with the answers and the lesson.

You can answer the questions here in the comments, or if you are in our Medicowesome Whatsapp group, you can message me (Jay) or Upasana privately with your name and answer. I will post the names of the first 5, who gave the correct answers with our next post.

Enjoy!


DEFINITION OF TERMS

1. Consent - The consent or receiving the willingness of the patient to undergo a medical procedure is a must before you would perform any medical procedure. It could be ranging from a simple needle prick test or to an imaging or an operation.
2. IVF - Intra Venous Fluid. These are the liquid substances directly delivered into a vein. 

.

Why is low voltage ECG seen in cardiac amyloidosis?

Short post because it is a cool fact!

Think before you order a test: High resolution CT scan (HRCT)

Hello, 

Let's talk about HRCT today!

HRCT is the use of thin-section CT images (0.625-mm to 1.5-mm slice thickness) with a high spatial frequency reconstruction algorithm, to detect and characterize diseases that affect the pulmonary parenchyma and small airways.

HRCT cuts THIN slices.

Awesome, isn't it? Why not use an HD camera for every photograph?

Because it comes with a price!

Treating Alcohol withdrawal - scheduled vs PRN benzodiazepines

Hello,

Sometimes it's frustrating to see different physicians use different approaches to management of the same condition or disease. How do you practice in that case?

You look at the evidence, the guidelines and make your own decision based on it.

Then even though if your attending practices something opposite of what the guidelines say, you know what is right and what you will practice in the future :)

Anyway, now that I am done venting - what do guidelines say about scheduled vs as needed benzodiazepines for alcohol withdrawal?

Chimeric antigen receptor T cells (CAR T cells) therapy simplified

Hey everyone! Upasana - our funny medical student made a simplified video on CAR T cell therapy. Check it out!

I copy-pasted a quick short post in text for reference :)