SLC gene Mutations and related Disease

Hello Awesomites!

Enjoy this crisp post on SLC gene mutations.

SLC= Solute carrier

SLC39A4	Acrodermatitis enteropathica
SLC26A4	Pendred
SLC6A9	Hartnup disease
SLC5A2	Renal glucosuria

FYI-Diseases associated with SLC6A4 include Anxiety and Obsessive-Compulsive Disorder

For further information read this article SLC transporters as therapeutic targets.

 -Upasana Y.

Facebook: Acid and Alkali ingestion question.

Q1) In a child with accidental alkali ingestion, which of the following is recommended as acute treatment:-

A) Administer mild acid

B) Administer milk

C) Administer rice

D) Gag the child to induce emesis

So answer to the above question is Milk, Option B.

For acute administration of caustic ingestion, dilution with milk or water is recommended.

Contraindications in case of caustic ingestion:-

1) Neutralization

2) Induce emesis

3) Gastric lavage

Some key points:-

Acid ingestion produces coagulative necrosis and a somewhat protective thick eschar.

Alkali ingestion produces:-

1) Liquefactive necrosis

2) Saponification of fat

3) Exothermic reaction

PS: Do follow our Facebook Medicowesome page for more such questions.

 

Topics to read before PG entrance exams!

Hello Awesomites!

The aim is to help the students who want to give upcoming NEET PG Exam and are clueless about how to plan and prepare ?
I know my friend struggling day in and out for life in Covid wards. Exams doesn't matter now.
When they will have time in hand I want to help them out with plan beforehand. They are already brilliant enough to have been through all the challenges. :)

I know you can't predict what is important for this or next exams. Atleast with time in hand you can glance through some topics that contribute 70% of any exam. I am sharing the list 1st year subject I made during my preparation.

1.ANATOMY

• Embryology 

1. Pharyngeal arches
2. Neural crest derivatives
3. Oogenesis and spermatogenesis
4. Notochord and remnants 
5. Extraembryonic mesoderm
6. Diaphragm 
7. Cardiovascular system ( Abnormal subclavian artery)
8. Urogenital system 

• Histology 

1. Cerebellum
2. Osteoblasts
3. Urinary bladder epithelium
4. Cell junctions
5. Collagen types
6. cartilage
7. Tonsil,Lymph nodes, spleen,thymus
8. Stomach glands
9. Skin with sebaceous glands
10. Connective tissue types
11. Retina 
12. Salivary gland

• NEUROLOGY

1. Fornix 
2. Corpus callosum
3. Cranial nerves and its lesion
4. Brainstem syndromes (lateral medullary )
5. Foramen of skull
6. Facial nerve and trigeminal nerve
7. blood brain barrier
8. Functional area and functional columns
9. Parasympathetic ganglion 
10. Phrenic nerve and vagus

• GROSS

1.  Compartments of lower limb with nerve and blood supply
2. Blood supply of thyroid,oesophagus,ureter,Anal canal 
3. Waldeyer ring
4. External carotid artery
5. Circle of willis
6. Muscle of eye
7. Brachial plexus (Sensory and motor supply of upper limb)
8. Perineum
9. Cruciate ligaments
10. Vocal cords
11. Mediastinum
12. IVC tributaries
13. Cavernous sinus and superior orbital fissure 
14. Splanchanic plexus

2. BIOCHEMISTRY

• Inborn error of metabolism (Types,Enzyme deficient,hallmark feature,Investigation of choice and treatment)
• Rate limiting step 
• Carbohydrate metabolism (Glycolysis,Glycogen storage disease,Glucogenesis,glycogenolysis,PFK-1)
• Lipid metabolism ( Hyperlipoproteinemia and hypolipoproteinemia)
• Vitamin (Coenzyme)
• Electron transport chain inhibitor
• Heme metabolism and Porphyria
• Ketone body formation 
• Urea cycle disorder
• Competitive, non competitive and allosteric inhibitors
• Mitochondrial disorders 
• Amino acid disorder
• Lead poisoning
• Translation process 

3.PHYSIOLOGY

• Receptors
• Neurotransmitter and functions
• Second messenger
• Reflexes
• Baroreceptors and chemorecptors
• JVP 
• ECG And EEG
• Spirometry
• RAAS 
• Counter current exchanger and multiplier
• Factors affecting compliance of lung 
• Action potential
• Smooth muscle and cardiac muscle
• Channels and types 
• GIT hormones 
• Tracts and lesions(brown sequerd syndrome)
• LH,FSH,GH and insulin glucagon

 Following are the list of 2nd year topics.

1.FORENSIC MEDICINE

• Ballistics (Bullet ranges)
• Identification (female male, blood sample)
• Recent amendments in acts (POCSO act, MTP Act)
• Application of IPC,CrPC sections
• Postmortem changes
• Dentition And Xray of wrist elbow and pelvis to determine age
• Injuries -fracture of skull, RTA, Bruise
• Toxicology- Plant based image, Preservation of viscera, Snakes,Arsenic, OP poisoning,Mercury,cadmium,Cardiac poison
• Consent
• Grievous hurt and murder vs culpable homicide
• Seminal stains
• Dowry death and Rape
• Battered baby syndrome
• Plant Toxicology (castor,abrus,strychnine,Dhatura,Aconite,Oleander,Calotropis,Opium,Cannabis)

2. PATHOLOGY-

• Breast cancer, Lung cancer and Ovarian and testicular cancer
• CD markers
• Hemolytic anemia
• Vasculitis
• Endocarditis And MI
• Types of hypersensitivity reaction
• Platelet and coagulation disorder(ITP,TTP,hemophilias,vWD)
• Stains And vacutainers
• Transfusion reaction 
• Graft rejction
• Crohns vs Ulcerative colitis
• Necrosis, apoptosis and its variant
• Mode of inheritance
• Leukemia and lymphoma prognostic markers
• Renal histology and gross
• Liver histology and gross
• CNS tumors 

3.PHARMACOLOGY

• Antimicrobial Drug of choice and mechanism of action 
• Classification - aminoglycoside , MRSA And drugs for cystic fibrosis
• Hypolipidemic Agents 
• Asthma ( New drugs and guidelines)
• Arthritis (RA and gout)
• General pharmacology ( Pharmacokinetics,clinical trial,Pharmacodynamics)
• Concentration dependent kinetics and time dependent kinetics and post antibiotic effect
• Anti TB drugs
• Anti viral and anti HIV (anti hep B and C)
• Anti fungal
• CVS- MI ,HF, angina managment
• Endocrine- DM,Osteoporosis,SERM,SERD,Gnrh agonist
• GIT-Constipation (opioid induced,IBS related) ,Diarrhea,peptic ulcer
• CNS-Anti epileptic, Sedative,lithium toxicity,neurodegenerative disorder, side effect 
• ANS- Emergency medicines,anaphylaxis, receptors ,poisoning 
• Chemotherapy-Anticancer,monoclonal antibody,small molecules,kinase inhibitors
• Prostaglandins 
• Insulin 

4.MICROBIOLOGY-

• Sterilisation and disinfection (Indicator)
• Immunology (Antibody,complement deficiency,Primary immunodeficiency)
• Latest outbreaks (Zika,Congohemorrhagic fever,Ebola,Corona)
• Sexually transmitted infections
• Vectors
• Parasitology -Eggs
• Congenital infections-Toxoplasmosis,congenital syphillis,rubella,herpes,varicella
• HPV infection,HHV-8
• Bioterrorism
• Larva migrans,larva currens (cutaneous and visceral)
• CD4 counts and Opportunistic infection
•  HIV and TB
• Food poisoning
• Atypical bacteria treatment and infection 
• Dimorphic fungi
• Actinomycosis,Botryomycosis and eumycetoma
• Meningitis
• Exanthematous disease
• Neisseria,diphtheria,Listeria,bacillus anthrax,legionella,campylobacter jejuni
• Bacterial virulence factors,growth factors
• Rickettsial disease, spirochetes(weils ds) 
• Drug resistance mechanism

Following is the list of 3rd year topics.

1.COMMUNITY MEDICINE-

• Surveillance programs
• Sensitivity, specificity,PPV and NPV (Screening of disease)
• Types of studies 
• Odds ratio and relative risk ratio
• Bias
• Sampling 
• Biostatistics- central tendency  (Box and whisker plot )
•  Level of prevention 
• Vaccine and types (Toxoid and live attenuated)
• Demography and family planning
• Biomedical waste
• Health programmes ( RNTCP, HIV)
• Communication
• Nutrition and related programmes
• Disaster
• Null hypothesis,P value and alpha value
• Confidence limit 

2.OPHTHALMOLOGY-

•  Refractive errors (Astigmatism)
• Surgery and post op complication(Glaucoma,cataract,squint)
• Conjuctivitis
• Corneal ulcer (Bacterial,fungal and herpetic) (Stains)
• ROP and systemic retinopathy (Hypertensive and diabetic retinopathy)
• Retinitis pigmentosa and syndromes
• Retinal detachment and cause
• Retinoblastoma
•  Strabismus
• Optic neuritis
• Visual field defect 
• Blow out fracture and trauma to eye
• Glaucoma and drugs(Contraindication and indication)
• Managment of ptosis
• Light reflex and accomodation reflex and pupil
• 3,4,6 Cranial nerve
•  OCT ,Fluorescein angiograhy,tonometers,charts,
• Sudden loss of vision and gradual loss of vision differentials

3. ENT-

• Appearance of tympanic membrane in various disease
• Surgery (Tonsillectomy,Adenoidectomy,Mastoidectomy)
• Paranasal sinus
• CSF rhinorrhea
• Laryngeal disease (Papilloma,vocal cord paralysis, laryngeal muscles action, laryngeal cancers)
• Tracheostomy
• Abscess 
• Nasopharyngeal carcinoma
• Juvenile angiofibroma
• Test of hearing and vertigo
• Otosclerosis
• Cochlear implants
• Oral cavity cancers 
• cervical Lymph node  and neck dissections

 Following is the list of Final year topics.

 1.OBSTETRIC AND GYNECOLOGY-

• Pre-eclampsia (Definitions)
• HELLP
• PPH (prophylaxis and treatment)
• Perineal tear (Types and managment)
• Diabetes and anomalies scan 
• Shoulder dystocia maneuvers
• Molar pregnancy (High risk and low risk for GTN)
• Ectopic (Diagnosis, Investigation and managment)
• Abortions 
• Recurrent pregnancy loss (Investigations and causes)
• Cervical incompetence
• MTP
• Diagnosis and physiological changes of pregnancy 
•  Abruptio vs placenta previa vs Vasa previa
• Heart disease
• MgSO4 and drug
• Fetal monitoring -NST,BPP,doppler
• Twins and complications
• Labor-stages,partogram
• Placenta types and associated pathology
• Rh incompatibility
• Amenorrhea (primary and secondary)
• Mullerian anomalies (Class)
• Asherman, AIS,Gonadectomy indication
• Puberty and precocious puberty
• Menopause (Hormone replacement therapy guidelines) 
• Postmenopausal bleeding and premature ovarian failure (Levels of FSH)
• Semen analysis (Evaluation and IUI and TESE)
• PCOS -Diagnosis,drugs
• Endometriosis
• Cervical,vulval,ovarian,endometrial cancer,Fibroid
• Krukenberg
• PID
• Prolapse 
• Emergency contaceptives
• IUD
• Absolute contraindications in whole subject
• Female sterilisation  

2.PEDIATRICS-

• Developmental milestones
• Neonatal reflexes
• Neonatal resuscitation
• Jaudice,sepsis,Hyaline membrane disease
• Congenital infections-TORCH
• Vaccines(IAP and NIS)
• Diarrhea,pneumonia,dehydration managment
• Pediatric epilepsy
• Febrile seizure (Risk factors,recurrent risk,prohylaxis)
• Severe acute malnutrition
• Rickets
• meningitis
• Neuro-Cerebral palsy and neurocutaneous syndrome
• Pediatric vasculitis-HSP and Kawasaki Disease
•  Nephrotic syndrome
• Congenital heart disease( VSD,TOF,TGA and ductus dependent CHD)
• Trisomies
• Hypoxic Ischemic encephalopathy VS Periventricular leukomalacia
• Fluid managment including shock managment in children
• Childhood pneumonia, Epiglottitis, Acute laryngotracheobronchitis
• Microcephaly and macrocephaly 
• Hydrocephalus and Neural tube defect  
• Fetal alcohol syndrome,warfarin syndrome

3. ANESTHESIA-

• IV anesthetic agents (Propofol)
• Day care surgery (Drug of choice)
• Venous air embolism
• Local anesthetic (Remember concentration also)
• Vaporisers color 
• Inhalational agents 
• Monitoring (Capnography)
• Color coding of cylinder
• Circuits
• Mallampati and ASA grading
• Premedication duration of stoppage and continuation
• Muscle relaxant
• Airway devices
• Endotracheal tube (formula)
• Epidural vs spinal anesthesia (Level of blocks)
• Modes of ventilation

 4.DERMATOLOGY-

•  Pigmentation Diseases 

1. Hyperpigmentation
2. Nevus (Nevus of ota/mongolian spot/CMN/AMN)
3. Melasma
4. Acanthosis nigricans
5. Becker nevus
6. Hypopigmentation -PKDL/Pityriasis versicolor/alba/Hansens
7. Depigmentation-Vitiligo/Contact leukoderma

• Signs (Auspitz,nikolsky,bulla spread sign)
• Histopathology of psoriasis and lichen planus
• Mast cell disorder-Urticaria pigmentosa image
• Papulosquamous disease - Psoriasis ,lichen planus
• Treatment of Psoriasis
• STD (Syphillis,chancroid,donovanosis,Herpes genitalis,syndromic approach)
• Microbiology of STD organism( Dark ground,school of fish,Tzanck smear,Donovan body,Gonococcus)
• Drug Reaction -Fixed drug eruption, erythema multiforme,SJS/TEN
•  Blistering disease 

1. Pemphigus(clinical treatment)
2. Bullos pemphigoid
3. dermatitis herpetiformis
4. Histopathology of blister level and Direct immunofluorescence image

• Infections

1. Fungal (Tinea /pityriasis versicolor)
2. Hansens 
3. TB
4. Viral (HPV/HHV/Molluscum contagiosum)

• Hair disease-Alopecia images,DLE,trichotillomania
• Acne,Rosacea
• cutaneous markers of internal malignancy

5.RADIOLOGY-

• Emergency radiology-RTA,splenic injury,FAST,Perforation
• Radiological anatomy especially applied aspect
• CNS tumor
• Bone tumor
• BIRADS
• TIRADS
• Radiation physics and acute radiation syndrome
• Radiotherapy basics
• Contrast in various studies
• USG and doppler
• Doppler waveforms

6.ORTHOPEDICS-

• Knee joint (Everything)
• Shoulder dislocation
• Bone (Oncology+radiological picture)
• Pediatric Hip(Rdaiology +managment)
• Infections(TB,Osteomyelitis)
• CTEV
• AVN
• Tennis elbow and dequeverian
• Eponyms and test
• Blood supply of femur
• Pseudoarthrosis
• Genu varum/valgus,cubitus varus/valgus
• malunion 
• Instruments

7.SURGERY-

• Glasgow coma scale (Changes)
• Burn
• Cannula color coding 
• Triage
• Trauma
• Incisions,suture,foleys,NG tube,Knots,Scores
• Latest updates in breast cancer,thyroid and hepatobiliary cancers,Pancreatic cancer,stomach,colorectal cancer
• Bed sores staging 
•  Renal stones managment
• Gall stone managment and surgical complication
• Bariatric surgery
• Acute pancreatitis managment 
• Upper GI and lower GI bleed management and causes
• Aortic aneurysm
• Meckel diverticulum
• Wound classification
• Cancer-(Breast,rectum,stomach,oesophagus,HCC,prostate,thyroid)
• Cancer follow up duration 
• Carcinoid and GIST and gastrinoma

 8.MEDICINE-

•  ECG visuals
• Cardiac emergencies-Arrest,Unstable angina,MI,Arrhythmia,Dissection
• Respiratory emergency-Pulmonary embolism,pneumothorax,Asthma 
• Stroke
• Meningitis (Bacterial,viral,aseptic)
• Approach to patient in Coma
• Seizure
• Electrolyte imbalance
• ABG
• Hypertension and its emergency and management
• Murmurs and valvular lesions
• Pericardial d/o
• hepatitis(Viral,autoimmune)
• Non alcoholic and alcoholic liver disease
• Glomerular disease
• UTI
• CKD
• DM (management of different complications)
• Neurodegenerative d/o ,neuropathy,myopathy
• Septic shock guidelines
• GBS
• Poisoning 
• New asthma guidelines
• RTA and Inherited channelopathies
• MEN syndrome
• SIADH, DI,Pheochromocytoma
• AIDS defining illness
• Connective tissue disorder
• Infective endocarditis and rheumatic heart disease
• Prakinson and alzheimers
• IBS,UC ,Crohns
• Cardiomyopathy
• Jones and dukes criteria
• dyslipidemia management 

10.PSYCHIATRY-

• General psychiatry (terms and its meaning )
• MMSE
• Psychotic disorders

1. Schizophrenia
2. Delusional d/o- Named syndromes (Capgras,Fregoli,Othello,Ekbom)

• Mood disorder (Treatment is very important)

1. Mania
2. Depression
3. Bipolar

• Neurotic disorder 

1. Anxiety disorder
2. OCD related disorder
3. Dissociative disorder
4. Trauma and stress related disorder
5. Somatoform disorder

• Substance abuse and deaddiction
• Organic mental disorder(dementia)
• Sleep disorder
• Eating disorder
• Sexual disorder
• Personality types and disorder
• Drugs (SSRI and its sideeffect)
• Psychotherapy types and choice
• Defence mechanism  

You can edit this according to you. 

Hope it will help.

-Upasana Y.

Plan your preparation

Hi Awesomites!

Let us begin with journey for upcoming NEET PG and AIIMS PG.
Today I will share with you the tips on "How to plan your preparation for NEET PG?"

"An hour of planning can save you from hours of doing nothing."

Essentials:-
1.Google calendar or Print out of calendar   -->Get printable calender here
2.Pen
3.Blank paper

I) Google calendar:-

I started my preparation in March. I had schedule of the rotations beforehand.
Lesson 1:- "Do you have 9 months for Jan NEET PG ?"
"No"
It seems so we have months for prep but we have only days .
So make realistic plan by counting out the days you will be busy with TND and grand tests.
To see how your whole year going to look like make a virtual plan.
I color coded each event I had for the entire year.

Purple-The posting in the given month
Green-The days I am free
Blue-The test and discussion day
Orange-The test and discussion I missed
Red-Grand test

II) Take out print or write on paper specifying 19 subjects :-

After every Grand test I list out the topics I am weak at.
Lesson 2:- You are not weak at subject, you are weak at topics in that subject.

III) Stick to one resource.

IV) Make separate and single notebook for test and discussion . Do not add everything in notes in one go.

V) Take breaks.

VI) Do passive studying when you are exhausted .
- I recorded the nerve injuries and certain ADR of drugs in my phone and used to listen it whenever I was unable to carry notes.

- I used to call my friends and discuss the topic after we are done with targets for the day.

VII) Don't be hard on yourself.Give some time to things you love.


Hope this will help.

-Upasana Y.

Tympanogram.

Hello Everybody!

Let us quickly review the different curves of a tympanogram. 

The following are the yypes of curves in you'll see on a tympanogram:

Type A – Normal pressure and normal compliance in normal ear.

Type A_s – Reduced compliance (‘s’ means stiffness leading to reduced compliance) and normal pressure.

• Seen in
  • Otosclerosis or other ossicular fixation
  • Tympanosclerosis

Type A_d – Increased compliance (‘d’ means discontinuity leading to increased mobility) and normal pressure.

• Seen in
  • Ossicular discontinuity
  • Thin and lax TM

 

Type B – Flat or dome shaped graph i.e. reduced compliance.

Seen in case of:Serous otitis media.

Thick tympanic membrane.

Type C – Normal compliance but negative pressure due to eustachian tube obstruction.

• Seen in case of:
• Retracted tympanic membrane,
• Early stages before collection of fluid in middle ear.

Hope this was helpful. 

Let's Learn Together! 

Dr. Medha Vyas 

Coronary artery anatomy mnemonic and video for visualization

Let's learn about the coronary artery anatomy today (and never forget it!)

Watch the video. Text and images below.

Funnel Plot

-also called as Begg’s plot
-type of scatter plot
-used to examine biases in meta-analyses

An ideal funnel plot is symmetric.
If no biases, 95% of studies lie within the triangle.

Lysosomal storage diseases mnemonic

Acute Liver Failure in a nutshell.

Acute Liver Failure is defined as the acute onset of severe liver injury with encephalopathy and ↓ synthetic function (INR ≥ 1.5 ) in a patient without  cirrhosis or underlying known liver disease.

Acute Liver Failure.

Rickettsia mnemonic

Hi!

Do you want to learn about Rickettsia today?

Rickettsia mnemonic (Rickettsia typhi, flea vector)

Schroeder's Vs Bandl's ring

Schroeder's  Vs Bandl's ring

Bandl's ring:- 

1) It is seen in obstructed labour

2) It is a pathological ring

3) It is a retraction ring

4) It moves up with uterine contractions

5) It can be palpable per-abdominally but not pervaginally

(Remember- Bandl has A after B which stands for per-abdominally)

6) Management: Like obstructed labour, C-section and antibiotics.

Schroeder's ring:-

1) Seen when oxytocin is used judiciously.

2) It is a physiological ring.

3) It is a constriction ring.

4) It is fixed ring, does not move with uterine contractions

5) It can be palpable pervaginally but not per-abdominally.

6) Management: It dissolves on it's own.

If not, then management in first stage of labour includes C-section.

Management in second stage includes forceps or c section.

That's it!

Demotional bloke

Mnemonic for Catalytically perfect enzymes !!

Hii...

Certain rare enzymes , 

They are so efficient that almost every time enzyme meets its substrate, the reaction occurs. 

E + S ➡️ ES Complex ➡️ Instantaneously Product formed 

For such enzymes this becomes the rate limiting step & is only determined by 

Rate of Diffusion of molecules in solution.

Means , Catalytically perfect reactions are only limited by substrate diffusion rate.( Substrate diffusion into active site ) 

This enzymes are called Diffusion limited/ Catalytically perfect enzymes.

Catalytic efficiency reaches the diffusion limit.

Examples =

Furiously trying to CAtCh ( think Ball) diffusion limit in Superover.

Fumarase 

Triose phosphate isomerase 

Catalase 

Cytochrome C peroxidase

CAH ( Carbonic anhydrase )

AchE ( Ach esterase ) 

Ball = Beta lactamase 

Superover = SOD = Superoxide Dismutase 

Thank you...

By Drashtant

A compilation of similarities between corneal dystrophies

Many dystrophies have commonalities. Following are enumerated as under-

1. Associated with TGF Beta1 mutations-

       - Epithelial basement membrane dystrophy

       - Reis- Bückler's 

       - Thiel- Behnke 

       - Lattice and granular(type1) dystrophies

2. Associated with mutations on 5q31 locus-

         - Reis- Bückler's

         - Lattice and granular(types 1 and  2)

3. Autosomal recessive -

          - Gelatinous drop like

          -.macular

          - Congenital hereditary endothelial( type 2)

4. X linked- 

           - Lisch ( X linked dominant) 

-All others are autosomal dominant. 

5. Chromosome 12- Meesman's, congenital 

                                     hereditary stromal.

6. Chromosome 20- Posterior polymorphous, 

                                    congenital hereditary 

                                     endothelial.

7. Chromosome 1- Gelatinous drop like,

                                   posterior polymorphous.

8. Amyloid deposition is seen in- 

                   - Gelatinous drop like

                   - Lattice

                   - Granular (type2) 

                   - Congenital hereditary endothelial.

9. Bowman's membrane is lost in- 

                   -Gelatinous drop like

                   - Reis-Bückler's (replaced by irregular

                       material

                   - Thiel-Behnke's ( replaced by a

                       fibrocellular layer)

10. Recurrence after keratoplasty-

                    -  Reis-Bückler's

                    -. Lattice, granular, and macular

                    - Schynder 

                     -  Congenital hereditary stromal.

11. Association with glaucoma and keratoconus-

                    - Posterior polymorphous

                    - Fuch's endothelial. 

Now don't blame me for the list being too exhaustive 🙄

Source- Postgraduate ophthalmology by Zia Chaudhari and M Vanathi 

-Sushrut 

Correct order of Stage of Death

Proposed by Kubler Ross 

" Mnemonic = DA BudDhA "

D Denial = Refuse to believe Dx 

A Anger = Frustrated , Ask "Why Me ? "

B Bargaining = in return for a cure , they promise to fulfill one or many pledges ( Charity ) 

D Depression 

A Acceptance = Realize that death is inevitable

Thank you 

By Drashtant 

Facebook: Wolffian duct

Q1) Ejaculatory duct in males develops from 

A) Ureteric bud

B) Mesonephric duct

C) Wolffian duct

D) Paramesonephric duct

#Medicowesome

#Gynaecology

Answer to this question is Option C) Wolffian duct.

But isn't Wolffian duct also called as Mesonephric duct ? So can you pick option B instead of option C?

Well, unless your exam allows multiple answers to be correct, do not pick 'Mesonephric duct'. Here is why?

The mesonephros gives mesonephric duct which opens in the Urogenital Sinus and forms trigone of the bladder. Mesonephric duct also gives ureteric bud to the Metanephros to form Renal system.

Now after this has happened, the Mesonephric duct will be called as Wolffian Duct which forms the internal genital organs and in females, disappears.

That's it!

Demotional bloke

Mnemonic for head posture in A-V pattern squints

Chin up in what? Chin down in what? The vexing never ends. Well, as it turns out, the word 'vex' itself is here to save the day.

Chin up- V exotropia (VEx). Remember that squint is very 'vexing'. So you stare in the sky to remember at least a fraction of what you stuffed in your brain the day before. 

Other will be A esotropia. By exclusion, it's easy to remember. 

Chin down- V esotropia or A exotropia. Again, by exclusion, these get placed naturally under this heading.

So, just remember 'VEX' and you won't be vexed anymore! 

-Sushrut