Monday, November 14, 2016

Radiolucent stones mnemonic and uric acid calculi

Good morning! =)

I was studying about radiolucent kidney stones and thought of sharing what I learnt with you all.

Mnemonic for radiolucent renal calculi: CATIX URL
Cysteine
Adenine (2,8-Dihydroxyadenine)
Triamterene
Indinavir
Uric acid
RadioLucent

Another mnemonic for medication stones: GUEST MIC
Guaifenesin stones (Radiolucent)
Ephedrine stones (Radiolucent)
Sulphonamides stones (Radiolucent)
Triamterene stones (Poorly radiopaque)
Magnesium trisilicate stones (Poorly radiopaque)
Indinavir stones (Radiolucent)
Cephalosporins stones (Radiolucent)

If you are asked to choose the radiolucent one between Orotic acid stones and cysteine stones, choose orotic acid. It is radiolucent, cystine is poorly radioopaque.

Magnesium ammonia phosphate (struvite) and Cystine calculi are less radiodense and are more difficult to visualize. Uric acid, orotic acid, xanthine, triamterene, dihydroxy­adenine, and indinavir calculi are radiolucent and might not be seen on a plain radiograph.
(Source.)

Predisposing factors for uric acid stones:
1. Low urinary pH
2. High uric acid excretion

Treatment for uric acid stones:
1. Alkalinization of urine
(Sodium bicarbonate, potassium citrate)
2. Increase fruits, veggies. Decrease animal flesh.
3. XOI - Allopurinol, Febuxostat

Alkalinization of urine mnemonic: ABC.
Alkalinization. Bicarbonate. Citrate.
(Sodium bicarbonate and potassium citrate are used for alkalinization of urine)

That's all!
-IkaN

Study group discussion: Cold agglutinin disease and extravascular hemolysis in liver

We were discussing a MCQ from pathologystudent.

Here's the question:

On a routine physical examination of an elderly male patient with no other medical problems, you note that his earlobes and fingertips are pale and slightly bluish. A CBC shows a hemoglobin of 10.6 g/dL (12 – 16) and an MCV of 88 (80 -100). Numerous red blood cell agglutinates are seen on the blood smear, made by smart technologists in your laboratory. Which of the following statements is true?

1. The antibody bound to the patient’s red blood cells in this disorder is probably IgG
2. Complement is probably bound to the patient’s red cells
3. The spleen is the main site of red cell destruction in this patient
4. 1 and 3
5. 1, 2, and 3

1 is not true. It's cold agglutinin disease. The main antibody is IgM here.

2 is correct since complement is involved.

The main site of destruction is liver macrophages (Kupffer cells). Therefore, 3 is incorrect.

Is there a specific reason for it?

Liver RECs have loads of C3 specific receptors. So most extravascular hemolysis that occurs in cold agglutinin disease is in the liver.

Another common mechanism of hemolysis in cold agglutinin disease is direct complement mediated intravascular hemolysis.

There's C3b on RBC and macrophage has CR3 (Complement receptor 3).

Liver macrophages lack the capacity of spleen to sequester cells. Hence, here the RBC destruction in liver occurs by phagocytosis predominantly.

Thanks, Divya, for explaining this.

Sunday, November 13, 2016

Tourette syndrome mnemonic

Hello!

For those who don't know -

Tourette syndrome is a disorder involving multiple motor and vocal tics, for at least a year, before 18 years of age.
Mnemonic: T for Tourette, T for Tics!

Tourette syndrome is associated with ADHD and OCD.

Mnemonic: TAO!
Tourette - ADHD, OCD.

Treatment - Antipsychotics like tetrabenazine, risperidone, fluphenazine are preferred.
Clonidine and Clonazepam maybe useful.

That's all!

-IkaN

Friday, November 11, 2016

Step 2 CK: CLL notes and staging mnemonic

Hey!

Chronic lymphocytic leukemia is proliferation of normal B lymphocytes that function abnormally.

The WBC count in CLL is > 20,000/flL with 80-98% lymphocytes.

Smudge cells are seen in CLL.

Staging of CLL mnemonic

High  LSAT score :D

Stage 0: High WBC
Stage 1: Lymphadenopathy
Stage 2: Splenomegaly + Hepatomegaly
Stage 3: Anemia
Stage 4: Thrombocytopenia

For stage 0 and stage 1, no treatment is required.

Therapy is indicated for patients with advanced stage disease, high tumor burden, severe disease-related "B" symptoms, or repeated infections.

Hepatosplenomegaly, anemia and thrombocytopenia are preferably treated with fludarabine and rituximab (FR).

For refractory cases, cyclophosphamide can be used (FCR regimen)

Older individuals (> 65 years of age) can be treated with ibrutinib, a bruton’s tyrosine kinase (BTK) inhibitor (preferred) or chlorambucil plus anti-CD20 monoclonal antibodies.

Autoimmune hemolysis or thrombocytopenia is treated with prednisone (Autoimmune warm IgG antibodies)

CLL has a good prognosis compared to other leukemias. Most common cause of death is due to infection.

That's all!
-IkaN

Tuesday, November 8, 2016

Bulbar and pseudobulbar palsy mnemonic

Hello! This is a mini post on bulbar and pseudobulbar palsy.

Bulbar palsy is the paralysis of the muscles supplied by the cranial nerves coming out from the bulb also known as the medulla (Cranial nerves 9, 10, 12) and it is lower motor neuron palsy.

Pseudobulbar palsy is paralysis of the same cranial nerves but the upper motor neuron type. Mostly due to lesions in the brain.

Mnemonic: pseUdo has a U for UMN lesion.

That's all!
-IkaN

Monday, November 7, 2016

Cataplesy and cataplexy mnemonic

Awesomite: Hi! Urgent mnemonic help. So can you tell me how I can remember this -

A case with dyspnea and blurring of vision

A 63-year-old male presented with increasing fatigability and dyspnoea for 2 months, and headache and blurring of vision for past 15 days. Physical examination was significant for pallor, mild hepatomegaly and a palpable spleen (2 cm).
Labs showed:
Hemoglobin concentration of 4.0 g/dL
Total white cell count of 25000/cmm
Platelet count of 60000/cmm
Monoclonal gammopathy (M spike) was seen in gamma globulin region, which turned out to be IgM on immunofixation.
Fundus examination revealed venous dilatation, tortuosity and superficial retinal hemorrhages.

Diagnosis? Treatment?

Thursday, November 3, 2016

Non-Hodgkins lymphoma treatment (CHOP regimen) mnemonic

Hey!

If you can't remember the drugs used in the CHOP regimen of Non-hodgkin's lymhoma, I have a mnemonic for you.

Hodgkins lymphoma treatment (ABVD regimen) mnemonic

Hey!

If you can't remember the drugs used in the ABVD regimen of Hodgkin's lymhoma, I have a mnemonic for you.

Study group discussion: ADP fibrinogen test

What is ADP (Adenosine diphosphate) fibrinogen test?

ADP, formed by Ib receptor, acts on IIb IIIa receptor through fibrinogen and causes aggregation.

In vWD and Bernard Soulier disease (Ib defect), if you add ADP, aggregation would take place and test will be normal as it acts on IIb IIIa receptor.

In glanzmann thrombasthenia, the IIb IIIa receptor is deficient. ADP can not act on the receptor, if added. That's why, the test becomes abnormal.

Therefore, the test is normal in vWD, Bernard soulier disease and abnormal in glanzmann thrombasthenia.

Explained by Abhishek Shukla

Homocysteine metabolism notes for USMLE

Hey!

Let's do a quick and dirty Q&A post :D

Homocysteine metabolism

Wednesday, November 2, 2016

PATCHED: When the tonsils shows a membrane

Hello everyone.

I'm back with a simple mnemonic to deal with a questionably common but very important issue: The Patch On The Tonsil.

Difference between neuroleptic malignant syndrome and serotonin syndrome

Neuroleptic malignant syndrome:
Evolves over one to three days.
Sluggish neuromuscular responses (Rigidity, bradyreflexia)
Typical course: Mental status changes appear first, followed by rigidity, then hyperthermia, and autonomic dysfunction (Tachycardia, high BP, tachypnea)

Step 2 CK: AML (Acute myelogenous leukemia) notes

Hello! So these are my notes on AML :)

Treatment of AML mnemonic

Hi.

The mnemonic for treatment of AML is ABCD!

Monday, October 31, 2016

Fever : What questions to ask your patient and why

Fever
So we're familiar with the definition and measurement of fever. But while taking a case or interacting with a patient with this simple and most basic symptom , what all should we ask for to make sure we don't miss out on anything ?
Here's a list of things your Historytaking should elicit :
Ask for :

1. Onset and Duration.
When did the fever begin - and for how long has it lasted. (This would give a clue whether the person suffers from an Acute Febrile Illness - which can generally be attributed to Infectious Disease , or a rather Chronic form of fever which could be due to Granulomatous diseases or even Neoplastic and Autoimmune conditions )

2. Progression.
(Has it worsened or Become better since its onset. This gives a clue about the present status of the patient. )

3. Chills , Rigors , Sweat .
(It's essential to include the presence or absence  of chills+Rigors + Sweat immediately in the fever description. Presence of Chills and Rigors indicate any infectious process in the body and can be found in Malaria and UTI's among other conditions. Sweating after feeling hot and then cold  is characteristically associated with Malaria)
(Important : Presence of the B Symptoms - which are Night Sweats ; Fever ; Weight loss. Seen with Lymphomas and TB)

4. Periodicity .
(It's of extreme value to understand the pattern of the fever.
If the fever is present throughout the day with a variation of not more than 1°C it is of the Continuous Type : As seen in Enteric Fever and even UTI's .
If the fever is present throughout the day but the variation is more than 1°C it is of the 'Remittent' variety. It may not be possible to distinguish between these 2 on history alone.
Intermittent is when the fever stays only for some duration during the day and the patient is afebrile during the remaining part )

5. Diurnal variation ?
(Night rise of fever could be suggestive of Tuberculosis)

6. Associated with Rash or any Spots ?
(Viral exanthems like Dengue , Chikungunya , Zika or even Rickettsial diseases commonly present with some form of rashes)
(Another possibility could be a primary Skin condition induced fever )

7. Arthralgia , Myalgia ?   
(Arboviruses like Dengue and Chikungunya are infamous for these. Arthralgia is especially debilitating in Chikungunya fever. Body ache is also common in both. Retro-orbital pain and Bifrontal headache are common with Dengue.)

8.  Icterus , High colored urine.
(Presence of these  - especially during the post monsoon season should raise suspicion of Leptospirosis or Acute Viral hepatitis. Enteric fever may be considered)

9. Cough , weight loss?
(Presence of these should raise query of TB or Pneumonia )

10. Dysuria, urgency , frequency?
( UTI is a common cause of AFI especially in Diabetics )

11. Altered sensorium, photophobia , vomiting ?
( Characteristic of Meningitis /Encephalitis)

12. Eating outside , GI disturbances ? (Enteric fever or Gastroenteritis should be suspected )


I hope this gave a crisp summary of how a fever case can be approached . Goodbye ! Happy-Treating !
A.P.Burkholderia

Sunday, October 30, 2016

Study group discussion: Why are agglutinates not seen in warm type autoimmune hemolytic anemia?

Why are agglutinates not seen in warm type autoimmune hemolytic anemia?

Because the antibody is IgG. IgG is called incomplete antibody.

RBCs have a strong negative charge on their surface called zeta potential. So the shortest distance attainable between two RBCs is 18nm. IgM molecule has a large pemtameric structure, so it has a distance of 30 nm between two binding sites. Hence, it is able to agglutinate RBCs.

But the small IgG molecule has only 12 nm gap between two binding sites. So it can't bind to multiple RBCs and hence fails to agglutinate them.

So it just coats the RBCs, which is taken to spleen to be killed.

That's all!

Thank you, Divya, for explaining this to us =)

-IkaN

Saturday, October 29, 2016

Marijuana and cannabinoids intoxication mnemonic

Hey!
So in this post, imma gonna talk about what happens when you smoke weed yo.

The symptoms of marijuana intoxication are:


Munchies (Polyphagia)
Autonomic hyperactivity (Mild hypertension, dry mouth)
Racing heart (Tachycardia)
Injection (Scleral, conjunctival injection)
Judgement impaired
Uphoria (Euphoria)
Anxiety
Nystagmus
Ataxia

Treatment? Intoxication is self-limited to several hours. Interestingly, the treatment for marijuana intoxication and withdrawal are exactly the same: supportive care only.
That's all!
Don't do pot, you dope, you :P
-IkaN

Step 2 CK: Treatment of narcolepsy and cataplexy

Treatment of Narcolepsy:
Patients with sleepiness severe enough to require medication can be treated with stimulant medications.

IPC and CrPC mnemonics

Hello!
This post is for Indian medical students only.

IPC 319, 320, 323, 324, 325, 326, 334, 335 mnemonic

Hey!

Narcolepsy mnemonic

Hello!

This post is on narcolepsy.

For those who don't know, narcolepsy is characterized by:

Crown rump length and gestational sac diameter

The crown rump length in mm is calculated by subtracting 42 from the gestational age in number of days.

The gestational sac diameter in mm is calculated by subtracting 30 from the gestational age in number of days.

Friday, October 28, 2016

Step 2 CK: Treatment of bipolar disorder

For acute maniac episode:
Give antipsychotic (preferably IM) like Olanzapine, Haloperidol first because they act fast.

Long term treatment for Bipolar disorder: Mood stabilizer like lithium.

If patient is on mood stabilizer and presents with maniac episode: Give antipsychotic.

For patients who have a history of multiple recurrences or have a partial but inadequate response to a maintenance drug that is tolerated, add a second drug:

Common combinations include lithium or valproate:
- Plus  a second-generation antipsychotic, such as quetiapine, long-acting injectable risperidone, ziprasidone, or olanzapine
- Lamotrigine
- Carbamazepine

Step 2 CK: Treatment of anxiety disorders

Patient is in a panic attack:
Use benzodiazepines because they act fast.

Long term treatment for panic disorder:
SSRIs

Long term treatment for GAD:
SSRIs
Buspirone

Tuesday, October 25, 2016

IPC 300, 302, 307, 308 and 309 mnemonic

Hello!

Here are some Indian Penal Code mnemonics :)

Study group discussion: Bradycardia

Name the causes of bradycardia!

Physiological bradycardia is seen during sleep and in athletes.

In typhoid fever, yellow fever and brucellosis, we see relative bradycardia.

Pathological bradycardia is seen in hypothermia, hypothyroidism, raised intracranial tension & inferior wall myocardial infarction, hypertension, bradyarrhythmia, etc.

What is relative bradycardia?

Indices of obesity mnemonic

Hello!
Let's mnemonic-fy everything!

Saturday, October 22, 2016

Authors diary: IkaN's real name (Meaning and pronunciation of Nakeya)

Hello!

IkaN from Medicowesome here!
This video and post is from the authors diary! :D

People have been asking me what my real name is and how I pronounce it so I thought of making a video on it.

There you go! :)

Wolff–Chaikoff effect mnemonic

Hello!

Here's an awesome mnemonic on Wolff–Chaikoff effect sent to us by Hari!

For those of you who don't know what Wolff–Chaikoff effect is, it is a reduction in thyroid hormone levels caused by ingestion of a large amount of iodine.

Thursday, October 20, 2016

Schizophrenia subtypes mnemonic

Schizophrenia types mnemonic: CURDP

Diagnosis vs. Prognosis! Which is which?


When I was in 1st year I used to mistake these two parts of patient care very much. Let’s try to understand these concepts.

Diagnosis (Dx) – The identified disease/condition that the person has. We get to a diagnosis, after considering all the symptoms, and signs.

Prognosis – What’s going to happen in future for the patient regarding this disease.

Wednesday, October 19, 2016

Step 2 CK: ADHD treatment

Hello! This post is on the treatment of Attention Deficit Hyperactive Disorder (ADHD)!

Cognitive behavioural therapy is the first line of treatment for ADHD.

As for pharmacotherapy, FDA has approved two types of medications — stimulants and non-stimulants.

Monday, October 17, 2016

Study group discussion: Dopamine, prolactin, Parkinson's disease and Schizophrenia

A schizophrenic presents with galactorrhea. The patient’s medication regimen includes haloperidol. Blockade of which  neurotransmitters is responsible for this patient's clinical presentation?

Dopamine. Since it is a Prolactin Inhibitor - Inhibition of Dopamine causes hyperprolatctinemia.

Doubt: Level of dopamine also decreases in Parkinson's disease. So can hyperprolactinemia also be seen in Parkinson's disease?

In Parkinson's, there is loss of dopamine only in the substantia niagra.

There are 4 main dopaminergic pathways in the CNS:
1. Nigrostrial pathway which is involved in Parkinson's disease.
2. Mesolimbic pathway involved in Schizophrenia.
3. Paraventricular pathway involved in satiety.
4. Tuberoinfundibular pathway involved in prolactin secretion.

Drugs can affect all pathways, that's why, the side effects. But Parkinson's only hits the nigrostrial pathway.

Sunday, October 16, 2016

Study group discussion: Dead space

What is dead space?

Physiologic or total dead space is the sum of anatomic dead space and alveolar dead space. Anatomic dead space is the volume of gas within the conducting zone (as opposed to the transitional and respiratory zones) and includes the trachea, bronchus, bronchioles, and terminal bronchioles; it is approximately 2 mL/kg in the upright position. Alveolar dead space is the volume of gas within unperfused alveoli (and thus not participating in gas exchange either); it is usually negligible in the healthy, awake patient.

Flexion of the head decreases dead space. Why?

Flexion of head decreases anatomical dead space. Therefore, physiological dead space will also be decreased.

Neck extension and jaw protrusion can increase the dead space twofold.

Supine position decreases dead space and the dead space increases in upright position. Why?

In upright position, there is decreased perfusion to the uppermost alveoli.

Intubation decreases dead space by 70 ml approx. Why?

The size of the ET tube is smaller than the trachea. Therefore, reduction in the dead space.

Administration of bronchodilator increases dead space. Why?

The conduction zone, from the nose to the respiratory bronchioles, is dead space. Bronchodilators dilate the brochus and bronchioles and not the alveoli, increasing dead space.

Certain anaesthetics, like halothane and sevoflurane, cause bronchodilation. Hence, an important concept and MCQ.

The cause of increased dead space in general anesthesia is multifactorial, including loss of skeletal muscle tone and loss of bronchoconstrictor tone.

That's all!

Pray that my goals are completed on a timely basis. I need your prayers.

-IkaN

Apoptosis - Quick review

Apoptosis is ' Programmed Cell death'

It is a physiologic and a Pathologic phenomenon.

There are 2 pathways of apoptosis-
A. Extrinsic pathway- a/ w activation of caspase 8
B. Intrinsic pathway- a/w activation of caspase 9

Most striking feature- Absence of inflammation.
Earliest feature- Cell shrinkage
Most characteristic feature- Nuclear pyknosis

Friday, October 14, 2016

Diabetes Mellitus - Oral Treatment

Diabetes Mellitus (DM) is a heterogeneous group of disorders, characterised by hyperglycaemia and it's complications.

Hyperglycaemia according to American Diabetes Association is when
1. Fasting Blood Sugar level is more than or equal to 126mg/dL
2. Post prandial Blood sugar is more than or equal to 200mg/dL

The interesting part is here
DM Type 2 is either because of
i) increased glucose production by the liver ( when a person is sleeping) or
ii) impaired insulin secretion ( usually noticed after meals as insulin reserves are not sufficient or there is insulin resistance)

Let's talk of 2 scenarios,
In case i) Fasting blood glucose is high and
In case ii) Post Prandial blood glucose is high.

Now,
For case i), Metformin which is said to decrease the glucose production from liver is a better treatment option.
(Remember, Metformin also works against Insulin Resistance, so it also works in case ii !)

For case ii), since the problem is with insulin secretion or its resistance, Insulin Secretagogs work the best! Sulfonylurea increase the insulin secretion from ß cells in the pancreas, thereby tackling the problem.
Remember, Sulfonylureas are commonly used after Metformin!

If you want a super drug :P to tackle both these scenarios then Metformin and Thiazolidinediones are your best options. However, the side effect profile of the latter one is worrisome so used less often.

Here's one of my favourite quotes, Hardwork beats talent when talent doesn't work hard !
That's all!

- Rippie

Wednesday, October 12, 2016

Lights, Pokemon, Seizures!

Did you know light can induce seizures?

Photic-induced seizures — Photosensitivity has received considerable attention as a seizure trigger. The light stimulation may come from a natural or artificial source, in particular television shows and video games.

Deviation of the tongue, jaw, uvula and lips in cranial nerve palsy mnemonic

Hello! Long time no see (From my side :D )

So in this post, I'll be taking about what deviates where with a mnemonic! Yaay!
What? Jaw, tongue, lips and uvula.

Let's start with LMN lesions of the respective cranial nerves.

Tuesday, October 11, 2016

Two interesting facts.

Hey awesomites! Happened to read two interesting things today-

1. The Y sperm is relatively lighter due to the acrocentric chromosome, amounting to the relatively skewed sex ratio towards males across the globe.

2. Homeobox gene 8 controls the expression of forelimbs, messing with it causes alters the position of the forelimbs.

That's all!


Monday, October 3, 2016

Concepts vs mnemonics

"There are two ways to learn something - One is through pure logic  ie, from first principles (building up a concept). The other is mnemonics (To help retrieve info quickly... To avoid all the time and thinking taken to derive it).

The best thing is to learn both ways. If you forget the mnemonic, you can derive it from the concept. If you forget the concept, you'd at least have the mnemonic." - SG

Many people question whether mnemonics really help. This is what I have to say in explanation. Learn both like SG said. They'll help if you manage to remember, if you forget, you can use your knowledge and understanding to come to the same conclusion.

That's all!

SG is a good friend and is very philosophical on learning. These are some random thoughts that she sent and I thought of sharing them because I strongly agree!

-IkaN

Sunday, October 2, 2016

Transmission of toxoplasmosis

Toxoplasmosis is transmitted through:
Cat bite
Droplets
Orofecal route
Cat scratch

This is a tricky question if you haven't revised parasitology. You'll vaguely remember the association with cats, so you'll be tempted to pick one which mentions the word cat.

Remember, toxoplasmosis is transmitted through cat feces, so orofecal route is the correct answer.

That's all!
-IkaN

Saturday, October 1, 2016

Friday, September 30, 2016

Step 2 CK: GBS prophylaxis mnemonic

Hi!

Drugs used for GBS prophylaxis mnemonic: PACE CV
Penicillin
Ampicillin
Cefazolin
Erythromycin
Clindamycin
Vancomycin

Indications of GBS prophylaxis:
- Previous infant with invasive GBS disease.
- GBS bacteriuria / positive culture during current pregnancy.
- Unknown GBS status with:
- Delivery at < 37 weeks
- Amnionic membrane rupture > 18 hours
- Intrapartum temperature > 100.4 (38.0)

That's all!
-IkaN

Thursday, September 29, 2016

Most common sites of bone tumors mnemonic

I made these mnemonics on request by an awesomite, Yashwanth.
Here's the most common sites list he sent, mnemonics follow.